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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0.11

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transport (Trpc6) mitochondrion (Nfkb1) DNA binding (Nfkb1)
protein complex (Nfkb1) transmembrane transport (Trpc6) cytoplasm (Nfkb1)
Anatomy Link Frequency
podocytes 1
Nfkb1 (Mus musculus)
Trpc6 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 1 76.64 Quite High
member 8 1 75.40 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 9 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treated with extracellular signal-regulated kinase (ERK) pathway specific inhibitor U0126 or nuclear factor-kappaB (NF-kappaB) pathway specific inhibitor ammonium pyrrolidinedithiocarbamate (PDTC) and Ang II, respectively in podocytes, not only was the TRPC6 up-regulation reduced, but the podocyte apoptosis was also decreased.
nuclear factor-kappaB Binding (Treated) of TRPC6 in podocytes associated with apoptosis
1) Confidence 0.35 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.74 Pain Relevance 0.11

General Comments

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