INT1612

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Context Info
Confidence 0.62
First Reported 1979
Last Reported 2005
Negated 2
Speculated 3
Reported most in Abstract
Documents 19
Total Number 22
Disease Relevance 2.34
Pain Relevance 12.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 8
blood 2
spinal cord 2
pituitary 2
forebrain 2
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 58 100.00 Very High Very High Very High
Morphine 33 100.00 Very High Very High Very High
Enkephalin 18 100.00 Very High Very High Very High
narcan 7 100.00 Very High Very High Very High
Kappa opioid receptor 6 100.00 Very High Very High Very High
orphanin 3 100.00 Very High Very High Very High
cocaine 6 99.98 Very High Very High Very High
Opioid 16 99.84 Very High Very High Very High
Pain 3 99.82 Very High Very High Very High
nociceptor 2 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Volume Depletion And Dehydration 4 100.00 Very High Very High Very High
Nociception 2 100.00 Very High Very High Very High
Injury 7 99.98 Very High Very High Very High
Hypertension 7 99.28 Very High Very High Very High
Stress 5 97.12 Very High Very High Very High
Frailty 1 91.32 High High
Urological Neuroanatomy 2 91.24 High High
Diabetes Insipidus 1 87.12 High High
Spinal Injuries 2 87.08 High High
Pressure And Volume Under Development 1 66.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of the divalent cations, Mn2+, Mg2+ and Ca2+ on rat forebrain delta-, mu- and kappa-receptor binding was examined during postnatal development.
Regulation (effect) of kappa-receptor Binding (binding) of in forebrain
1) Confidence 0.62 Published 1987 Journal Brain Res. Section Abstract Doc Link 3030506 Disease Relevance 0 Pain Relevance 0.21
Quantitative autoradiography was used to examine the effects of dehydration on kappa-opiate receptor binding in the neural lobe of the pituitary in rats.
Spec (examine) Regulation (effects) of kappa-opiate receptor Binding (binding) of in pituitary associated with volume depletion and dehydration and opiate
2) Confidence 0.62 Published 1987 Journal Brain Res. Section Abstract Doc Link 2827842 Disease Relevance 0.36 Pain Relevance 0.17
Alterations in opiate receptor binding in the hippocampus of aged Long-Evans rats.
Regulation (Alterations) of opiate receptor Binding (binding) of in hippocampus associated with enkephalin, hippocampus and opiate
3) Confidence 0.57 Published 1996 Journal Brain Res. Section Title Doc Link 8866710 Disease Relevance 0 Pain Relevance 0.88
The effect of chronically given morphine on the binding of ovine prolactin (oPRL) to specific areas in the male rat brain was studied.
Regulation (effect) of oPRL Binding (binding) of in brain associated with morphine
4) Confidence 0.56 Published 1994 Journal FEBS Lett. Section Abstract Doc Link 8307182 Disease Relevance 0 Pain Relevance 0.36
Effect of sodium chloride on opiate receptor binding in spontaneously hypertensive rats: dependence on age.
Regulation (Effect) of opiate receptor Binding (binding) of associated with addiction, hypertension, narcan and opiate
5) Confidence 0.50 Published 1985 Journal Clin Exp Hypertens A Section Title Doc Link 2986883 Disease Relevance 0.64 Pain Relevance 0.41
Furthermore, they have been characterized by the use of low concentrations of radiolabelled agonists and antagonists and through the ability of GTP to influence differentially their binding to the opiate receptor (for refs. see: 2).
Regulation (influence) of opiate receptor Binding (binding) of associated with antagonist, agonist and opiate
6) Confidence 0.41 Published 1982 Journal Life Sci. Section Abstract Doc Link 6298526 Disease Relevance 0 Pain Relevance 0.97
The influence of stereochemistry as well as the substitution pattern of the phenyl-ring in position 1 on the affinity for the orphanin FQ receptor and selectivity to opioid (mu, kappa, delta) receptors is discussed.
Regulation (influence) of orphanin FQ receptor Binding (affinity) of associated with orphanin and opioid
7) Confidence 0.40 Published 1999 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 10476866 Disease Relevance 0 Pain Relevance 0.37
Morphine-like peptides: their regulation in the neuroendocrine system and the effect of guanyl nucleotides and divalent ions on opiate receptor binding.
Regulation (effect) of opiate receptor Binding (binding) of associated with opiate and morphine
8) Confidence 0.40 Published 1980 Journal Prog Biochem Pharmacol Section Title Doc Link 6255486 Disease Relevance 0 Pain Relevance 0.68
ORL1 peptide-stimulated [35S]GTP gamma S binding was unaffected by opioid or other G-protein-coupled receptor antagonists.
Neg (unaffected) Regulation (unaffected) of ORL1 Binding (binding) of associated with antagonist and opioid
9) Confidence 0.39 Published 1996 Journal Neuroreport Section Abstract Doc Link 8733732 Disease Relevance 0 Pain Relevance 0.31
Opiate receptor binding affected differentially by opiates and opioid peptides.
Regulation (affected) of Opiate receptor Binding (binding) of associated with opiate and opioid
10) Confidence 0.36 Published 1979 Journal Eur. J. Pharmacol. Section Title Doc Link 220062 Disease Relevance 0 Pain Relevance 1.60
Alterations in nociceptive reactivity, opiate receptor binding, and other behavioral responses occur in rats exposed to morphine either in utero or post-natally.
Regulation (Alterations) of opiate receptor Binding (binding) of associated with nociception, opiate and morphine
11) Confidence 0.27 Published 1989 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2505292 Disease Relevance 0.36 Pain Relevance 0.84
An in vivo autoradiographic technique permitted the visualization of discrete neuroanatomical changes in opiate receptor binding as a result of 23-h water deprivation and drinking.
Regulation (changes) of opiate receptor Binding (binding) of associated with opiate
12) Confidence 0.27 Published 1987 Journal Brain Res. Section Abstract Doc Link 3036314 Disease Relevance 0 Pain Relevance 0.17
[Central effects of ORL1 receptor ligands].
Regulation (effects) of ORL1 Binding (ligands) of associated with nociceptor
13) Confidence 0.24 Published 2003 Journal Eksp Klin Farmakol Section Title Doc Link 14650219 Disease Relevance 0.09 Pain Relevance 0.25
We also examined whether changes in the mu- and kappa-opioid receptor binding occurred in the brain of morphine-treated animals.
Spec (whether) Regulation (changes) of kappa-opioid receptor Binding (binding) of in brain associated with kappa opioid receptor and morphine
14) Confidence 0.24 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9151297 Disease Relevance 0 Pain Relevance 0.85
Observations of changes in relative blood flow were shown to have no correlation with changes in opiate receptor binding.
Regulation (changes) of opiate receptor Binding (binding) of in blood associated with opiate
15) Confidence 0.24 Published 1987 Journal Brain Res. Section Abstract Doc Link 3036314 Disease Relevance 0.27 Pain Relevance 0.59
Cocaine alters opiate receptor binding in critical brain reward regions.
Regulation (alters) of opiate receptor Binding (binding) of in brain associated with opiate and cocaine
16) Confidence 0.24 Published 1989 Journal Synapse Section Title Doc Link 2537540 Disease Relevance 0 Pain Relevance 1.01
These results suggest that although the sites for GTP regulation and opiate receptor binding are physically distinct, interactions between sites occur upon the binding of either opiate or guanine nucleotide ligands to their respective sites, and that sodium may play a crucial role in the coupling of these interactions.
Regulation (regulation) of opiate receptor Binding (binding) of associated with opiate
17) Confidence 0.23 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6088761 Disease Relevance 0 Pain Relevance 0.52
Selective alterations in guanine nucleotide regulation of opiate receptor binding and coupling with adenylate cyclase.
Regulation (alterations) of opiate receptor Binding (binding) of associated with opiate
18) Confidence 0.22 Published 1983 Journal Life Sci. Section Title Doc Link 6319864 Disease Relevance 0 Pain Relevance 0.14
Traumatic injury alters opiate receptor binding in rat spinal cord.
Regulation (alters) of opiate receptor Binding (binding) of in spinal cord associated with injury, enkephalin, opiate and spinal cord
19) Confidence 0.21 Published 1986 Journal Ann. Neurol. Section Title Doc Link 3013077 Disease Relevance 0.62 Pain Relevance 1.14
The compound (100 microM) significantly decreased the specific binding of [3H]D-Ala2, N-Me-Phe4, Gly5-ol-enkephalin (DAMGO) and [3H]D-Pen2, D-Pen5-enkephalin (DPDPE) at the mu- and delta-opioid receptor, respectively, but has no effect on the binding of [3H]U-69,593 at the kappa-opioid receptor of rat brain slices.
Neg (no) Regulation (effect) of kappa-opioid receptor Binding (binding) of in brain associated with kappa opioid receptor, opioid receptor and enkephalin
20) Confidence 0.16 Published 2005 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 18426082 Disease Relevance 0 Pain Relevance 0.46

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