INT161206

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 9.68
Pain Relevance 3.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
lymphocytes 4
macrophages 2
monocytes 2
alveolar macrophages 2
fibroblasts 2
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 108 100.00 Very High Very High Very High
Inflammation 225 99.44 Very High Very High Very High
alcohol 4 99.12 Very High Very High Very High
narcan 1 97.76 Very High Very High Very High
fibrosis 86 97.68 Very High Very High Very High
antagonist 7 97.40 Very High Very High Very High
Morphine 1 96.96 Very High Very High Very High
Inflammatory response 35 96.20 Very High Very High Very High
tramadol 1 94.04 High High
Analgesic 5 93.48 High High
Disease Link Frequency Relevance Heat
Cancer 414 100.00 Very High Very High Very High
Asthma 52 99.64 Very High Very High Very High
INFLAMMATION 265 99.44 Very High Very High Very High
Metastasis 115 99.16 Very High Very High Very High
Pulmonary Fibrosis 58 97.68 Very High Very High Very High
Apoptosis 40 97.60 Very High Very High Very High
Cervical Cancer 2 97.20 Very High Very High Very High
Adhesions 7 96.40 Very High Very High Very High
Chronic Lymphoid Leukemia 2 96.32 Very High Very High Very High
Prostate Cancer 51 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An alcohol extract of noni fruit puree also caused an inhibition of MMP-9 release from human monocytes after stimulation with LPS.
Negative_regulation (inhibition) of Localization (release) of MMP-9 in monocytes associated with alcohol
1) Confidence 0.59 Published 2010 Journal Phytother Res Section Abstract Doc Link 19548275 Disease Relevance 0.33 Pain Relevance 0.97
Furthermore, Pycnogenol, an anti-inflammatory drug is able to attenuate signs of inflammation in asthma patients through reduction of MMP-9 secretion [21].
Negative_regulation (reduction) of Localization (secretion) of MMP-9 associated with asthma and inflammation
2) Confidence 0.41 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 1.85 Pain Relevance 0.40
This is consistent with another study, mentioned above, in which apocynin, an inhibitor of NADPH oxidase, also inhibited the release of MMP-9 and MMP-2 in SP-D -/- alveolar macrophages [23].
Negative_regulation (inhibited) of Localization (release) of MMP-9 in alveolar macrophages
3) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.31 Pain Relevance 0.21
Zoledronate as well as alendronate has been found to inhibit secretion and activity of MMP-2 and MMP-9 by tumor cells and tumor-infiltrating macrophages in mouse models of cervical cancer [19] and prostate cancer [50].
Negative_regulation (inhibit) of Localization (secretion) of MMP-9 in macrophages associated with cervical cancer, cancer and prostate cancer
4) Confidence 0.22 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2294135 Disease Relevance 1.32 Pain Relevance 0
PDE4 inhibitor cilomilast was also shown to suppress the release and activation of MMP-1 and MMP-9 from lung fibroblasts, which are known to be involved in PF progression [18].
Negative_regulation (suppress) of Localization (release) of MMP-9 in fibroblasts associated with fibrosis
5) Confidence 0.17 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.72 Pain Relevance 0.25
Firstly, THL could inhibit, in cancer cells, the expression and secretion of MMP-2, MMP-9, and uPA (Fig 2A, C), which involve in degradation of extracellular matrix and play important roles in cancer cell migration and invasion [5,6,63].
Negative_regulation (inhibit) of Localization (secretion) of MMP-9 in extracellular matrix associated with cancer and metalloproteinase
6) Confidence 0.14 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 1.81 Pain Relevance 0.14
It reduced mRNA, protein synthesis, and secretion of MMP-9 (gelatinase B) in lymphocytes from patients
Negative_regulation (reduced) of Localization (secretion) of MMP-9 in lymphocytes associated with metalloproteinase
7) Confidence 0.14 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.11 Pain Relevance 0.55
Gelatin zymography assays indicated that THL dose-dependently inhibited the secretion of MMP-2 and MMP-9 in MDA-MB-231, H1299, PC-3 and CT-26 cancer cells (Fig 2A).
Negative_regulation (inhibited) of Localization (secretion) of MMP-9 in PC-3 associated with cancer and metalloproteinase
8) Confidence 0.13 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 0.86 Pain Relevance 0.44
It reduced mRNA, protein synthesis, and secretion of MMP-9 (gelatinase B) in lymphocytes from patients
Negative_regulation (reduced) of Localization (secretion) of gelatinase B in lymphocytes associated with metalloproteinase
9) Confidence 0.10 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.11 Pain Relevance 0.56
These results suggest that PDE 4 inhibitors are effective in inhibiting the pro-MMP-2 and pro-MMP-1 secretion induced by TNF-?
Negative_regulation (inhibiting) of Localization (secretion) of pro-MMP-2
10) Confidence 0.10 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 0.26 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox