INT161216

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.87
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Htr2b) plasma membrane (Htr2b) cytoplasm (Htr2b)
signal transducer activity (Htr2b)
Anatomy Link Frequency
liver 4
lung 1
heart 1
Htr2b (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 9 97.88 Very High Very High Very High
agonist 3 81.20 Quite High
Dopamine 3 80.84 Quite High
headache 3 75.84 Quite High
Migraine 3 75.44 Quite High
fibrosis 3 69.04 Quite High
Disease Link Frequency Relevance Heat
Valvular Heart Disease Other Than Mitral Valve Prolapse 6 89.64 High High
Carcinoid Heart Disease 9 85.60 High High
Disease 3 82.20 Quite High
Weight Loss 3 79.68 Quite High
Migraine Disorders 3 75.84 Quite High
Coronary Heart Disease 3 75.00 Quite High
Fibrosis 3 69.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
G-proteins that inhibit adenylate cyclase activity mediate the activity of the 5-HT2B receptor subunit, which is widely expressed in a variety of tissues, including liver, lung, heart, and coronary and pulmonary arteries; it has also been reported in embryonic mouse heart, particularly on mouse heart valve leaflets.
Positive_regulation (mediate) of Gene_expression (expressed) of 5-HT2B in liver
1) Confidence 0.49 Published 2009 Journal J Am Soc Echocardiogr Section Abstract Doc Link 19553085 Disease Relevance 0.62 Pain Relevance 0.39
G-proteins that inhibit adenylate cyclase activity mediate the activity of the 5-HT2B receptor subunit, which is widely expressed in a variety of tissues, including liver, lung, heart, and coronary and pulmonary arteries; it has also been reported in embryonic mouse heart, particularly on mouse heart valve leaflets.
Positive_regulation (mediate) of in lung Gene_expression (expressed) of 5-HT2B in liver
2) Confidence 0.17 Published 2009 Journal J Am Soc Echocardiogr Section Abstract Doc Link 19553085 Disease Relevance 0.62 Pain Relevance 0.39
G-proteins that inhibit adenylate cyclase activity mediate the activity of the 5-HT2B receptor subunit, which is widely expressed in a variety of tissues, including liver, lung, heart, and coronary and pulmonary arteries; it has also been reported in embryonic mouse heart, particularly on mouse heart valve leaflets.
Positive_regulation (mediate) of in heart Gene_expression (expressed) of 5-HT2B in liver
3) Confidence 0.17 Published 2009 Journal J Am Soc Echocardiogr Section Abstract Doc Link 19553085 Disease Relevance 0.62 Pain Relevance 0.39

General Comments

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