INT161217

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.55
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Htr2b) plasma membrane (Htr2b) cytoplasm (Htr2b)
signal transducer activity (Htr2b)
Anatomy Link Frequency
liver 1
heart valve 1
lung 1
heart 1
Htr2b (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 12 97.88 Very High Very High Very High
agonist 4 89.08 High High
Dopamine 4 88.72 High High
headache 4 83.72 Quite High
Migraine 4 83.32 Quite High
fibrosis 4 76.92 Quite High
Disease Link Frequency Relevance Heat
Valvular Heart Disease Other Than Mitral Valve Prolapse 8 98.76 Very High Very High Very High
Carcinoid Heart Disease 12 93.48 High High
Disease 4 90.08 High High
Weight Loss 4 87.56 High High
Migraine Disorders 4 83.72 Quite High
Fibrosis 4 76.92 Quite High
Coronary Heart Disease 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies have suggested that both right-sided and left-sided drug-induced heart valve disease involves increased serotoninergic activity and in particular activation of the 5-HT receptors, including the 5-HT2B receptor subtype, which mediate many of the central and peripheral functions of serotonin.
Positive_regulation (activation) of 5-HT2B in heart valve associated with valvular heart disease other than mitral valve prolapse and serotonin
1) Confidence 0.67 Published 2009 Journal J Am Soc Echocardiogr Section Abstract Doc Link 19553085 Disease Relevance 0.68 Pain Relevance 0.42
G-proteins that inhibit adenylate cyclase activity mediate the activity of the 5-HT2B receptor subunit, which is widely expressed in a variety of tissues, including liver, lung, heart, and coronary and pulmonary arteries; it has also been reported in embryonic mouse heart, particularly on mouse heart valve leaflets.
Positive_regulation (mediate) of 5-HT2B in liver
2) Confidence 0.67 Published 2009 Journal J Am Soc Echocardiogr Section Abstract Doc Link 19553085 Disease Relevance 0.62 Pain Relevance 0.39
G-proteins that inhibit adenylate cyclase activity mediate the activity of the 5-HT2B receptor subunit, which is widely expressed in a variety of tissues, including liver, lung, heart, and coronary and pulmonary arteries; it has also been reported in embryonic mouse heart, particularly on mouse heart valve leaflets.
Positive_regulation (mediate) of 5-HT2B in lung
3) Confidence 0.23 Published 2009 Journal J Am Soc Echocardiogr Section Abstract Doc Link 19553085 Disease Relevance 0.62 Pain Relevance 0.39
G-proteins that inhibit adenylate cyclase activity mediate the activity of the 5-HT2B receptor subunit, which is widely expressed in a variety of tissues, including liver, lung, heart, and coronary and pulmonary arteries; it has also been reported in embryonic mouse heart, particularly on mouse heart valve leaflets.
Positive_regulation (mediate) of 5-HT2B in heart
4) Confidence 0.23 Published 2009 Journal J Am Soc Echocardiogr Section Abstract Doc Link 19553085 Disease Relevance 0.62 Pain Relevance 0.39

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