INT161220

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 17.63
Pain Relevance 4.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) extracellular region (Ccl2) cytoskeleton organization (Ccl2)
cytoplasm (Ccl2)
Anatomy Link Frequency
macrophage 1
monocyte 1
plaques 1
adipose tissue 1
keratinocyte 1
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 472 100.00 Very High Very High Very High
Multiple sclerosis 278 99.50 Very High Very High Very High
Inflammation 616 99.16 Very High Very High Very High
Dorsal horn neuron 4 98.84 Very High Very High Very High
Arthritis 61 98.12 Very High Very High Very High
Inflammatory mediators 23 96.20 Very High Very High Very High
cytokine 236 94.04 High High
Neuropathic pain 8 92.64 High High
antagonist 56 92.44 High High
Peripheral nervous system 2 91.44 High High
Disease Link Frequency Relevance Heat
Obesity 93 100.00 Very High Very High Very High
Nervous System Injury 16 99.60 Very High Very High Very High
Demyelinating Disease 239 99.50 Very High Very High Very High
Cancer 49 99.48 Very High Very High Very High
Disease 254 99.36 Very High Very High Very High
Necrosis 33 99.24 Very High Very High Very High
INFLAMMATION 671 99.16 Very High Very High Very High
Recurrence 50 99.08 Very High Very High Very High
Multiple Sclerosis 354 99.04 Very High Very High Very High
Injury 26 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCR2 is the main, but not exclusive, functional receptor for CCL2 [4], and as discussed above, the CCL2 – CCR2 interaction appears to play a key role in the development of EAE lesions.
CCL2 Binding (interaction) of associated with multiple sclerosis
1) Confidence 0.46 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.69 Pain Relevance 0.11
Nevertheless, the data from EAE and observations in MS suggest that the CCR2 – CCL2 interaction is important in the development of plaques.
CCL2 Binding (interaction) of in plaques associated with multiple sclerosis
2) Confidence 0.46 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.97 Pain Relevance 0.19
We developed a novel method for visualizing CCR2 receptor activation in vivo by generating bitransgenic reporter mice in which the chemokine receptor CCR2 and its ligand MCP1 were labeled by the fluorescent proteins enhanced green fluorescent protein and monomeric red fluorescent protein-1, respectively.
MCP1 Binding (ligand) of associated with chemokine
3) Confidence 0.36 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 0.95 Pain Relevance 0.79
The dysregulation of the calgranulins S100A8 and A9, in addition to CCL2 and IL8R?
CCL2 Binding (addition) of
4) Confidence 0.36 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.18 Pain Relevance 0.15
This observation confirmed the role of CCL2 – CCR2 interaction in the development of relapses.
CCL2 Binding (interaction) of associated with recurrence
5) Confidence 0.35 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.46 Pain Relevance 0.07
Quantitative ELISA to monitor tissue content for monocyte chemoattractant protein (MCP-1; CCL2 or JE in the mouse), keratinocyte-derived chemokine (KC; CXCL1), IL-1?
MCP-1 Binding (keratinocyte) of in keratinocyte associated with chemokine
6) Confidence 0.33 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.05 Pain Relevance 0.08
Transfectant-expressed CCRL2 has been reported to bind CCL2 and CCL5, although this result is controversial (9).
CCL2 Binding (bind) of
7) Confidence 0.30 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.12
Importantly, we observed a significant azithromycin-dependent decrease in G-CSF and decreased concentrations, albeit not statistically significant, of CCL2/JE, CCL3/MIP-1?
CCL2 Neg (not) Binding (concentrations) of
8) Confidence 0.28 Published 2010 Journal Respir Res Section Body Doc Link PMC2906448 Disease Relevance 0.64 Pain Relevance 0.33
MCP-1 and FKN can combine to their receptors [4,31,32] expressed on microglia and induce their activation.
MCP-1 Binding (combine) of in microglia
9) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2857828 Disease Relevance 0.18 Pain Relevance 0.60
Multiplex bead immunoassay (Lincoplex) was performed according to the manufacturer's protocol on the Luminex 100 platform to measure concentrations of KC/CXCL1, MCP-1/CCL2, MIP-1?
CCL2 Binding (concentrations) of
10) Confidence 0.26 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.07 Pain Relevance 0.19
as well as chemokine (C-X-C motif) ligands IP-10 (Cxcl10), KC (Cxcl1), and MCP-1 (Ccl2).
Ccl2 Binding (ligands) of associated with chemokine
11) Confidence 0.25 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 1.49 Pain Relevance 0.14
as well as chemokine (C-X-C motif) ligands IP-10 (Cxcl10), KC (Cxcl1), and MCP-1 (Ccl2).
MCP-1 Binding (ligands) of associated with chemokine
12) Confidence 0.25 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 1.43 Pain Relevance 0.14
Some of the differentially expressed proteins, for example, MCP-1 (CCL2), MIG (CXCL9), IP-10 (CCL10), and I-TAC (CXCL11), might indeed serve as markers for disease activity in SLE, because these were differentially expressed between active and inactive disease, and not only between SLE patients and controls.
MCP-1 Spec (might) Binding (serve) of associated with systemic lupus erythematosus and disease
13) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.09 Pain Relevance 0.05
Some of the differentially expressed proteins, for example, MCP-1 (CCL2), MIG (CXCL9), IP-10 (CCL10), and I-TAC (CXCL11), might indeed serve as markers for disease activity in SLE, because these were differentially expressed between active and inactive disease, and not only between SLE patients and controls.
CCL2 Spec (might) Binding (serve) of associated with systemic lupus erythematosus and disease
14) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.09 Pain Relevance 0.05
CCL2 did not interfere with anti-mCCRL2 mAb staining in our studies.
CCL2 Neg (not) Binding (interfere) of
15) Confidence 0.20 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0 Pain Relevance 0.12
Binding of CCL2 to its CCR2 receptor can also be blocked by RS-504393, which is able to inhibit macrophage infiltration and activation (Kitagawa et al 2004).
CCL2 Binding (Binding) of in macrophage
16) Confidence 0.18 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.69 Pain Relevance 0.41
CB exposure also enhanced RSV-induced airway hyperresponsiveness to methacholine, bronchoalveolar lavage (BAL) total protein, and virus-associated chemokines monocyte chemoattractant protein (MCP-1), macrophage inflammatory protein (MIP-1 alpha), and regulated upon activation, normal T cell expressed and secreted (RANTES).
monocyte chemoattractant protein Binding (associated) of in T cell associated with chemokine, inflammation and respiratory syncytial virus
17) Confidence 0.14 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.52 Pain Relevance 0.22
We analyzed the ability of saliva from Rhipicephalus sanguineus (common brown dog tick) to inhibit the binding of the I125-labeled chemokines CCL2, CCL5, and CXCL8, as well as CCL3, to their respective receptors using a scintillation proximity assay.
CCL2 Spec (analyzed) Binding (binding) of in saliva associated with chemokine
18) Confidence 0.13 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.60 Pain Relevance 0.45
Interleukin-8 (IL-8/KC), monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-?)
monocyte chemotactic protein-1 Binding (Interleukin-8) of in monocyte associated with necrosis and cancer
19) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756629 Disease Relevance 1.32 Pain Relevance 0.42
MCP-1 from hypertrophic adipocytes in obese adipose tissue can also trigger macrophage infiltration into adipose tissue and subsequently activates macrophages to release inflammatory mediators such as TNF-?
MCP-1 Binding (trigger) of in adipose tissue associated with inflammatory mediators and obesity
20) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2876247 Disease Relevance 2.21 Pain Relevance 0.32

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