INT161221

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 4.55
Pain Relevance 3.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) signal transduction (Ccr2) plasma membrane (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
peripheral nerve 6
dorsal root ganglia 2
Ccr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 20 100.00 Very High Very High Very High
Demyelination 4 100.00 Very High Very High Very High
Peripheral nervous system 8 99.04 Very High Very High Very High
chemokine 14 95.60 Very High Very High Very High
Inflammation 15 95.00 High High
Antinociceptive 4 88.48 High High
antagonist 10 83.84 Quite High
Multiple sclerosis 1 79.80 Quite High
Pain 16 76.88 Quite High
Central nervous system 1 50.40 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 20 100.00 Very High Very High Very High
Demyelinating Disease 5 100.00 Very High Very High Very High
Injury 5 100.00 Very High Very High Very High
Multiple Sclerosis 5 96.84 Very High Very High Very High
INFLAMMATION 25 95.00 High High
Pain 8 76.88 Quite High
Targeted Disruption 8 75.00 Quite High
Shock 1 74.40 Quite High
Apoptosis 1 34.32 Quite Low
Mycobacterial Infection 3 27.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the status of CCR2 receptor activation in a demyelination injury model of neuropathic pain and found that MCP1-induced CCR2 receptor activation mainly occurred in the peripheral nervous system, including the injured peripheral nerve and dorsal root ganglia.
Positive_regulation (activation) of Spec (examined) Positive_regulation (activation) of CCR2 in peripheral nerve associated with demyelination, peripheral nervous system, injury and neuropathic pain
1) Confidence 0.50 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 1.07 Pain Relevance 0.96
We examined the status of CCR2 receptor activation in a demyelination injury model of neuropathic pain and found that MCP1-induced CCR2 receptor activation mainly occurred in the peripheral nervous system, including the injured peripheral nerve and dorsal root ganglia.
Positive_regulation (induced) of Positive_regulation (activation) of CCR2 in peripheral nerve associated with demyelination, peripheral nervous system, injury and neuropathic pain
2) Confidence 0.50 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 1.04 Pain Relevance 0.94
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (elevated) of Positive_regulation (levels) of Ccr2
3) Confidence 0.40 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.32 Pain Relevance 0.19
We examined the status of CCR2 receptor activation in a demyelination injury model of neuropathic pain and found that MCP1-induced CCR2 receptor activation mainly occurred in the peripheral nervous system, including the injured peripheral nerve and dorsal root ganglia.
Positive_regulation (activation) of in dorsal root ganglia Spec (examined) Positive_regulation (activation) of CCR2 in peripheral nerve associated with demyelination, peripheral nervous system, injury and neuropathic pain
4) Confidence 0.17 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 1.07 Pain Relevance 0.96
We examined the status of CCR2 receptor activation in a demyelination injury model of neuropathic pain and found that MCP1-induced CCR2 receptor activation mainly occurred in the peripheral nervous system, including the injured peripheral nerve and dorsal root ganglia.
Positive_regulation (induced) of in dorsal root ganglia Positive_regulation (activation) of CCR2 in peripheral nerve associated with demyelination, peripheral nervous system, injury and neuropathic pain
5) Confidence 0.17 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 1.04 Pain Relevance 0.94

General Comments

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