INT161222

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 13
Total Number 20
Disease Relevance 13.77
Pain Relevance 8.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) signal transduction (Ccr2) plasma membrane (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
monocytes 3
macrophages 2
peripheral nerve 2
dorsal root ganglia 2
sciatic nerves 1
Ccr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 21 99.76 Very High Very High Very High
Pain 41 99.70 Very High Very High Very High
Neuropathic pain 45 99.42 Very High Very High Very High
antagonist 71 99.30 Very High Very High Very High
Inflammation 383 99.08 Very High Very High Very High
Peripheral nervous system 23 99.04 Very High Very High Very High
chemokine 184 98.82 Very High Very High Very High
Multiple sclerosis 75 98.80 Very High Very High Very High
Antinociceptive 9 97.02 Very High Very High Very High
Spinal cord 18 79.48 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 92 99.76 Very High Very High Very High
Pain 23 99.70 Very High Very High Very High
Multiple Sclerosis 314 99.56 Very High Very High Very High
Targeted Disruption 95 99.50 Very High Very High Very High
Neuropathic Pain 45 99.42 Very High Very High Very High
Injury 36 99.20 Very High Very High Very High
INFLAMMATION 410 99.08 Very High Very High Very High
Stress 47 97.82 Very High Very High Very High
Disease 116 97.16 Very High Very High Very High
Rheumatoid Arthritis 10 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (levels) of Ccr2
1) Confidence 0.55 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.16
We examined the status of CCR2 receptor activation in a demyelination injury model of neuropathic pain and found that MCP1-induced CCR2 receptor activation mainly occurred in the peripheral nervous system, including the injured peripheral nerve and dorsal root ganglia.
Spec (examined) Positive_regulation (activation) of CCR2 in peripheral nerve associated with demyelination, peripheral nervous system, injury and neuropathic pain
2) Confidence 0.50 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 1.06 Pain Relevance 0.94
We examined the status of CCR2 receptor activation in a demyelination injury model of neuropathic pain and found that MCP1-induced CCR2 receptor activation mainly occurred in the peripheral nervous system, including the injured peripheral nerve and dorsal root ganglia.
Positive_regulation (activation) of CCR2 in peripheral nerve associated with demyelination, peripheral nervous system, injury and neuropathic pain
3) Confidence 0.50 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 1.04 Pain Relevance 0.94
In WT and Ccr2RFP/+Cx3cr1GFP/+ mice, equal numbers of F4/80+ monocyte/macrophages accumulated in the peritoneum (Figure 3B).
Positive_regulation (accumulated) of Ccr2RFP in macrophages
4) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.31 Pain Relevance 0.03
We previously showed that inflamed EAE tissues contain high levels of CCR2 and CX3CR1 ligands [26], [27], making this tissue ideal for comparing the trafficking properties of monocytes bearing either of the two cognate receptors.
Positive_regulation (levels) of CCR2 in monocytes associated with multiple sclerosis
5) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.83 Pain Relevance 0.03
Visualization of chemokine receptor activation in transgenic mice reveals peripheral activation of CCR2 receptors in states of neuropathic pain.
Positive_regulation (activation) of CCR2 associated with targeted disruption, pain, chemokine and neuropathic pain
6) Confidence 0.47 Published 2009 Journal J. Neurosci. Section Title Doc Link 19553445 Disease Relevance 0.94 Pain Relevance 0.96
These data explain the rapid antinociceptive effects of peripherally administered CCR2 antagonists under these circumstances, suggesting that CCR2 antagonists may ameliorate pain by inhibiting CCR2 receptor activation in the periphery.
Positive_regulation (activation) of CCR2 associated with pain, antagonist and antinociceptive
7) Confidence 0.47 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 0.83 Pain Relevance 0.80
CCR2 receptor activation under conditions such as acute inflammation and experimental autoimmune encephalomyelitis could be faithfully visualized by using these mice.
Positive_regulation (activation) of CCR2 associated with multiple sclerosis and inflammation
8) Confidence 0.47 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 1.04 Pain Relevance 0.91
However, whether CCR2 receptor activation occurs in the central or peripheral nervous system in states of neuropathic pain has not been clear.
Spec (whether) Positive_regulation (activation) of CCR2 in peripheral nervous system associated with peripheral nervous system and neuropathic pain
9) Confidence 0.47 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 0.75 Pain Relevance 0.66
We developed a novel method for visualizing CCR2 receptor activation in vivo by generating bitransgenic reporter mice in which the chemokine receptor CCR2 and its ligand MCP1 were labeled by the fluorescent proteins enhanced green fluorescent protein and monomeric red fluorescent protein-1, respectively.
Positive_regulation (activation) of CCR2 associated with chemokine
10) Confidence 0.47 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 0.93 Pain Relevance 0.77
The CCR2 promoter in the targeting vector was unchanged up to the first methionine of the open reading frame, as determined by sequence analysis.
Neg (unchanged) Positive_regulation (unchanged) of CCR2
11) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.51 Pain Relevance 0.07
In Ly6Chi monocytes, permeabilization increased the CCR2 signal twofold, indicating that approximately 50% of total CCR2 was cytoplasmic, but had little effect on CCR2 staining in Ly6Clo monocytes.
Positive_regulation (increased) of CCR2 in monocytes
12) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.27 Pain Relevance 0.06
These studies underscore the importance of CCR1 and CCR2 in the development of inflammatory demyelination and give support to novel alternative strategies targeting these CCR molecules.
Positive_regulation (importance) of CCR2 associated with demyelination and inflammation
13) Confidence 0.33 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.16 Pain Relevance 0.28
CCR2-/CD68-double positive cell number in postinfectious FD patients was significantly (P=0.009) increased compared with those in healthy volunteers.
Positive_regulation (increased) of CCR2
14) Confidence 0.22 Published 2010 Journal Am. J. Gastroenterol. Section Body Doc Link 20461070 Disease Relevance 0 Pain Relevance 0
Other inhibitors in clinical trial include the small molecule CCR2 inhibitors CCX915 (by ChemoCentryx) for multiple sclerosis (phase I), INCB3284 (by Incyte/Pfizer) which is in phase IIa for treatment of RA, and the monoclonal antibody ABN912 against CCL2 (by Novartis) for COPD (phase I) and RA (phase II).
Positive_regulation (inhibitors) of CCR2 associated with multiple sclerosis, pulmonary disease and rheumatoid arthritis
15) Confidence 0.18 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.79 Pain Relevance 0.33
Oxidative stress led to an influx of macrophages and increased expression of proteins like NADPH oxidase, thioredoxin- 1 and inducible nitric oxide synthase, via a CCR2- mediated mechanism (Hayasaki et al 2006).
Positive_regulation (inducible) of CCR2 in macrophages associated with stress
16) Confidence 0.18 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.53 Pain Relevance 0.06
We examined the status of CCR2 receptor activation in a demyelination injury model of neuropathic pain and found that MCP1-induced CCR2 receptor activation mainly occurred in the peripheral nervous system, including the injured peripheral nerve and dorsal root ganglia.
Positive_regulation (activation) of CCR2 in dorsal root ganglia associated with demyelination, peripheral nervous system, injury and neuropathic pain
17) Confidence 0.17 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 1.04 Pain Relevance 0.94
We examined the status of CCR2 receptor activation in a demyelination injury model of neuropathic pain and found that MCP1-induced CCR2 receptor activation mainly occurred in the peripheral nervous system, including the injured peripheral nerve and dorsal root ganglia.
Spec (examined) Positive_regulation (activation) of CCR2 in dorsal root ganglia associated with demyelination, peripheral nervous system, injury and neuropathic pain
18) Confidence 0.17 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 1.06 Pain Relevance 0.94
In WT and Ccr2RFP/+Cx3cr1GFP/+ mice, equal numbers of F4/80+ monocyte/macrophages accumulated in the peritoneum (Figure 3B).
Positive_regulation (accumulated) of Ccr2RFP in monocyte
19) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.31 Pain Relevance 0.03
RESULTS: CCL2/CCR2, CXCL10/CXCR3 and CCL5/CCR1, CCR5 expression was significantly increased in the sciatic nerves of sm-EAN mice compared with controls.
Positive_regulation (creased i) of CCR2 in sciatic nerves
20) Confidence 0.17 Published 2010 Journal Neuropathol. Appl. Neurobiol. Section Body Doc Link 20500551 Disease Relevance 0.07 Pain Relevance 0

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