INT161223

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.83
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) signal transduction (Ccr2) plasma membrane (Ccr2)
signal transducer activity (Ccr2)
Ccr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 4 99.92 Very High Very High Very High
antagonist 2 99.52 Very High Very High Very High
Antinociceptive 1 97.24 Very High Very High Very High
Peripheral nervous system 2 90.08 High High
Neuropathic pain 5 86.00 High High
Demyelination 1 84.68 Quite High
Inflammation 1 77.96 Quite High
chemokine 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Pain 2 99.92 Very High Very High Very High
Neuropathic Pain 5 86.00 High High
Injury 1 84.96 Quite High
Demyelinating Disease 1 84.68 Quite High
Multiple Sclerosis 1 79.80 Quite High
INFLAMMATION 1 77.96 Quite High
Targeted Disruption 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data explain the rapid antinociceptive effects of peripherally administered CCR2 antagonists under these circumstances, suggesting that CCR2 antagonists may ameliorate pain by inhibiting CCR2 receptor activation in the periphery.
Negative_regulation (inhibiting) of Positive_regulation (activation) of CCR2 associated with pain, antagonist and antinociceptive
1) Confidence 0.43 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 0.83 Pain Relevance 0.81

General Comments

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