INT161224

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Context Info
Confidence 0.52
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.09
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Ccr2) cytoplasm (Ccl2) cytosol (Ccr2)
extracellular space (Ccl2) signal transduction (Ccr2) extracellular region (Ccl2)
Anatomy Link Frequency
peripheral nerve 1
dorsal root ganglia 1
Ccl2 (Mus musculus)
Ccr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 10 99.68 Very High Very High Very High
Peripheral nervous system 4 99.04 Very High Very High Very High
Demyelination 2 99.02 Very High Very High Very High
Inflammation 2 91.32 High High
Antinociceptive 2 88.48 High High
antagonist 4 83.84 Quite High
chemokine 6 81.96 Quite High
Pain 8 76.88 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 10 99.68 Very High Very High Very High
Injury 2 99.16 Very High Very High Very High
Demyelinating Disease 2 99.02 Very High Very High Very High
Multiple Sclerosis 2 93.16 High High
INFLAMMATION 2 91.32 High High
Pain 4 76.88 Quite High
Targeted Disruption 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the status of CCR2 receptor activation in a demyelination injury model of neuropathic pain and found that MCP1-induced CCR2 receptor activation mainly occurred in the peripheral nervous system, including the injured peripheral nerve and dorsal root ganglia.
MCP1 Positive_regulation (activation) of CCR2 in peripheral nerve associated with demyelination, peripheral nervous system, injury and neuropathic pain
1) Confidence 0.52 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 1.04 Pain Relevance 0.94
We examined the status of CCR2 receptor activation in a demyelination injury model of neuropathic pain and found that MCP1-induced CCR2 receptor activation mainly occurred in the peripheral nervous system, including the injured peripheral nerve and dorsal root ganglia.
MCP1 Positive_regulation (activation) of CCR2 in dorsal root ganglia associated with demyelination, peripheral nervous system, injury and neuropathic pain
2) Confidence 0.18 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 1.04 Pain Relevance 0.94

General Comments

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