INT161248

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 10
Disease Relevance 6.47
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
brains 10
liver 2
neurons 2
Mtor (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 54 90.92 High High
anesthesia 10 74.04 Quite High
Hippocampus 45 65.60 Quite High
imagery 9 32.60 Quite Low
tolerance 1 25.00 Low Low
Immobilon 9 12.32 Low Low
Limbic system 27 5.00 Very Low Very Low Very Low
Locus ceruleus 9 5.00 Very Low Very Low Very Low
Neurobehavioral 9 5.00 Very Low Very Low Very Low
Substantia nigra 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 531 99.86 Very High Very High Very High
Disease 495 99.84 Very High Very High Very High
Targeted Disruption 90 97.96 Very High Very High Very High
Dementia 81 90.92 High High
Alcoholic Liver Cirrhosis 1 89.84 High High
Neurodegenerative Disease 81 88.76 High High
Cirrhosis 1 87.80 High High
Hepatocellular Cancer 1 85.48 High High
Neurological Disease 9 82.68 Quite High
Liver Disease 2 80.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the studies in human brains, levels of mTor and p-mTor were increased in the mebrane fractions from brains of ?
Positive_regulation (increased) of Gene_expression (levels) of p-mTor in brains
1) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.43 Pain Relevance 0.05
The increased levels of mTor and reduced Atg7 levels suggest there may be altered activation of the autophagy pathway in the brains of DLB patients.
Positive_regulation (increased) of Gene_expression (levels) of mTor in brains associated with parkinson's disease
2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.90 Pain Relevance 0.09
The increased levels of mTor and reduced Atg7 levels suggest there may be altered activation of the autophagy pathway in the brains of DLB patients.
Positive_regulation (increased) of Gene_expression (levels) of mTor in brains associated with parkinson's disease
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.91 Pain Relevance 0.09
Double-labeling studies showed that mTor and LC3 were abundant in neurons displaying ?
Positive_regulation (neurons) of Gene_expression (abundant) of mTor in neurons
4) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.14 Pain Relevance 0.10
Several advances have accompanied the increasing number of indications and these excellent results: (a) the development of more specific immunosuppressive drugs to prevent rejection, the incidence of which is currently less than 20%: tacrolimus, mycophenolic acid, anti-IL2 receptor antibodies, mTOR inhibitors, (b) a policy of active recruitment of organs together with surgical innovations (split liver, domino LT, living donor transplantation) contributing to the expansion of the pool of organs, (c) standardization of organ allocation policies, based on the sickest first policy.
Positive_regulation (increasing) of Gene_expression (antibodies) of mTOR in liver
5) Confidence 0.05 Published 2009 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 19556084 Disease Relevance 0.40 Pain Relevance 0.07
Compared to non-demented controls and AD cases, levels of mTor and phosphorylated-mTor (p-mTor) were elevated in the brains of DLB cases (Figure 1A, C).
Positive_regulation (elevated) of Gene_expression (levels) of mTor in brains associated with parkinson's disease and disease
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.78 Pain Relevance 0.03
-syn tg mice might be in part related to increased levels of mTor, we investigated whether blocking mTor with rapamycin might promote ?
Positive_regulation (increased) of Gene_expression (levels) of mTor
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.19 Pain Relevance 0.03
The mechanisms through which levels of mTor might be upregulated and Atg7 downregulated in DLB and ?
Positive_regulation (upregulated) of Gene_expression (levels) of mTor associated with parkinson's disease
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.84 Pain Relevance 0
Consistent with the studies in human brains, levels of mTor and p-mTor were increased in the mebrane fractions from brains of ?
Positive_regulation (increased) of Gene_expression (levels) of mTor in brains
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.43 Pain Relevance 0.05
By immunoblot analysis, compared to controls and AD, in DLB cases levels of mTor were elevated and Atg7 were reduced.
Positive_regulation (elevated) of Gene_expression (levels) of mTor associated with parkinson's disease and disease
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824828 Disease Relevance 1.45 Pain Relevance 0

General Comments

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