INT1613

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Context Info
Confidence 0.48
First Reported 1979
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 58
Total Number 59
Disease Relevance 10.55
Pain Relevance 28.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
brain 4
RVLM 4
intestine 3
smooth muscle 2
IPN 2
Nts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 297 100.00 Very High Very High Very High
Dopamine 168 100.00 Very High Very High Very High
Central grey 51 100.00 Very High Very High Very High
antagonist 48 100.00 Very High Very High Very High
substance P 41 100.00 Very High Very High Very High
Enkephalin 41 100.00 Very High Very High Very High
Neuropeptide 32 100.00 Very High Very High Very High
narcan 18 100.00 Very High Very High Very High
Rostral ventrolateral medulla 16 100.00 Very High Very High Very High
Dynorphin 15 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 378 100.00 Very High Very High Very High
Urological Neuroanatomy 57 100.00 Very High Very High Very High
Disease 20 99.62 Very High Very High Very High
Nociception 290 99.40 Very High Very High Very High
Stress 9 99.28 Very High Very High Very High
Neurological Disease 1 99.28 Very High Very High Very High
Peptic Ulcer 5 98.68 Very High Very High Very High
Depression 1 98.38 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

8 97.88 Very High Very High Very High
INFLAMMATION 90 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical characterization of the intramembrane interaction between neurotensin and dopamine D2 receptors in the rat brain.
neurotensin Binding (interaction) of in brain associated with dopamine
1) Confidence 0.48 Published 1991 Journal Brain Res. Section Title Doc Link 1839140 Disease Relevance 0 Pain Relevance 0.43
Desulfated CCK preferentially inhibited 125I-CCK binding to cerebral cortex (IC50 = 7 X 10(-8) M) rather than IPN (IC50 greater than 1 X 10(-6) M) or AP-NTS.
AP-NTS Binding (binding) of in IPN associated with ipn and cerebral cortex
2) Confidence 0.48 Published 1987 Journal J. Neurosci. Section Abstract Doc Link 3625281 Disease Relevance 0 Pain Relevance 0.60
Neurotensin: contractile activity, specific binding, and lack of effect on cyclic nucleotides in intestinal smooth muscle.
Neurotensin Binding (binding) of in smooth muscle
3) Confidence 0.47 Published 1979 Journal Eur. J. Pharmacol. Section Title Doc Link 220063 Disease Relevance 0 Pain Relevance 0.17
Ligand binding data for the preparation including the mucosa and submucosa indicated that [125I]neurotensin bound specifically to two sites having apparent equilibrium dissociation constants of approximately 0.046 and 0.37 nM.
neurotensin Binding (bound) of
4) Confidence 0.47 Published 1990 Journal Synapse Section Abstract Doc Link 2169072 Disease Relevance 0 Pain Relevance 0
Although the precise mechanisms are not clear, and the involvement of noradrenergic systems cannot be precluded, data are consistent with the idea that dopamine, released in response to a stressful experience for example, interacts with CRH and neurotensin in the extended amygdala to affect emotional responsiveness.
neurotensin Binding (interacts) of in amygdala associated with dopamine and amygdala
5) Confidence 0.47 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.60
Compound 1 binds to human neurotensin receptors 1 and 2 with IC(50) of 10.6 and 54.2 nM, respectively, and tolerance to the compound in a rat pain model did not develop after 12 days of daily administration.
neurotensin Binding (binds) of associated with pain and tolerance
6) Confidence 0.42 Published 2010 Journal J. Med. Chem. Section Abstract Doc Link 20481538 Disease Relevance 0.19 Pain Relevance 0.56
Dose responses of the relaxing effect of neurotensin and its analogs D-Arg8-neurotensin and D-Arg 9-neurotensin on tetrodotoxin-treated muscle gave EC50 values of 5 nM, 5.5 nM and 110 nM for the three peptides, respectively. [3H]Neurotensin bound specifically to membranes prepared from isolated longitudinal muscle strips of the guinea-pig intestine.
Neurotensin Binding (bound) of in intestine associated with tetrodotoxin
7) Confidence 0.41 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 220063 Disease Relevance 0 Pain Relevance 0.19
Autoradiograms of [125I]neurotensin bound to cross sections of the proximal and distal jejunum showed that the highest densities of silver grains were associated with the internal submucosal ganglia, external submucosal plexus and myenteric ganglia.
neurotensin Binding (bound) of in internal
8) Confidence 0.41 Published 1990 Journal Synapse Section Abstract Doc Link 2169072 Disease Relevance 0 Pain Relevance 0.06
Desensitization of the neurotensin receptors antagonized the contractile activity of neurotensin.
neurotensin Binding (Desensitization) of
9) Confidence 0.37 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7796847 Disease Relevance 0 Pain Relevance 0.16
Certain neurotensin localizations suggest an association of the peptide with functional brain systems preferentially involving these regions.
neurotensin Binding (association) of in brain
10) Confidence 0.37 Published 1979 Journal Brain Res. Section Abstract Doc Link 378326 Disease Relevance 0.16 Pain Relevance 0.62
Substance P, thyrotropin releasing hormone, and neurotensin receptors are also found in the medial and in the spinal vestibular nuclei.
neurotensin Binding (found) of in medial associated with substance p
11) Confidence 0.36 Published 1995 Journal Brain Res. Bull. Section Abstract Doc Link 7712206 Disease Relevance 0 Pain Relevance 0.39
Identification of neurotensin receptors associated with calcium channels and prolactin release in rat pituitary.
neurotensin Binding (associated) of in pituitary associated with calcium channel
12) Confidence 0.36 Published 1986 Journal J. Neurochem. Section Title Doc Link 2430057 Disease Relevance 0 Pain Relevance 0.10
The situation appears more complex for Nts mRNA which showed METH-mediated increases in both the presence and absence of DA.
Nts Binding (complex) of associated with dopamine
13) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.32
Galanin in the superficial dorsal horn may be released both from primary afferents and local neurons to modulate sensory processing in many different ways, including interacting with enkephalin, neuropeptide Y, neurotensin and substance P released from the same and/or other local neurons.
neurotensin Binding (interacting) of in neurons associated with neuropeptide, dorsal horn, enkephalin and substance p
14) Confidence 0.35 Published 1995 Journal Neuroscience Section Abstract Doc Link 7538639 Disease Relevance 0 Pain Relevance 0.54
The effect of unilateral dorsal root ganglionectomies or ventral rhizotomies on alpha 2-adrenoceptor binding to, and the substance P, enkephalin, and neurotensin content of, the cat lumbar spinal cord.
neurotensin Binding (binding) of in ventral associated with enkephalin, spinal cord and substance p
15) Confidence 0.34 Published 1987 Journal Neuroscience Section Title Doc Link 2441314 Disease Relevance 0 Pain Relevance 0.77
Additionally, the facilitatory and inhibitory effects of neurotensin appear to occur via interaction with multiple neurotensin receptors in the RVM that activate independent systems that descend in the ventrolateral funiculi and DLFs, respectively.
neurotensin Binding (interaction) of in RVM associated with rostral ventromedial medulla
16) Confidence 0.33 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9310442 Disease Relevance 0.43 Pain Relevance 0.51
Interactions of neurotensin with other neurotransmitter candidates are also suggested by its presence in areas enriched in norepinephrine, dopamine, serotonin, and substance P.
neurotensin Binding (Interactions) of associated with dopamine, neurotransmitter, serotonin and substance p
17) Confidence 0.32 Published 1979 Journal Brain Res. Section Abstract Doc Link 378326 Disease Relevance 0.15 Pain Relevance 0.61
The only apparent difference between rhizotomy and capsaicin treatment occurred in lamina IV, where rhizotomy produced a greater reduction than capsaicin. 3H-Neurotensin binding in sections from the same animals was unaltered after rhizotomy, indicating a lack of change in the populations of neurons containing neurotensin-binding sites.
3H-Neurotensin Binding (binding) of in lamina associated with qutenza
18) Confidence 0.32 Published 1987 Journal Synapse Section Abstract Doc Link 2843995 Disease Relevance 0 Pain Relevance 0.51
All together, these data raise the question of the existence of neurotensin receptor subtypes and confirm that the nature of neurotensin and dopamine interactions depends on the brain structures considered.
neurotensin Binding (interactions) of in brain structures associated with dopamine
19) Confidence 0.31 Published 1995 Journal Fundam Clin Pharmacol Section Abstract Doc Link 8808171 Disease Relevance 0.26 Pain Relevance 0.52
In membranes prepared from IPN, NTS, and AP, 3H-364,718 binding was of high affinity (Kd = 0.14 nM), saturable (Bmax = 20 fmol/mg protein), and inhibited by compounds previously shown to act at pancreatic CCK receptors.
NTS Binding (binding) of in IPN associated with ipn
20) Confidence 0.31 Published 1987 Journal J. Neurosci. Section Abstract Doc Link 3625281 Disease Relevance 0 Pain Relevance 0.59

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