INT16130

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 67
Total Number 67
Disease Relevance 27.43
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
plasma 5
cartilage 2
extracellular matrix 2
body 2
chondrocytes 1
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 112 100.00 Very High Very High Very High
Bioavailability 32 100.00 Very High Very High Very High
Snapping jaw 7 99.22 Very High Very High Very High
halothane 1 98.56 Very High Very High Very High
imagery 101 96.00 Very High Very High Very High
Osteoarthritis 70 94.08 High High
Inflammation 314 93.20 High High
opiate 2 92.92 High High
Central nervous system 1 91.44 High High
ischemia 5 83.44 Quite High
Disease Link Frequency Relevance Heat
Hyperinsulinism 51 100.00 Very High Very High Very High
Syndrome 108 99.96 Very High Very High Very High
Apoptosis 301 99.92 Very High Very High Very High
Diabetes Mellitus 259 99.92 Very High Very High Very High
Acromegaly 203 99.88 Very High Very High Very High
Colon Cancer 80 99.76 Very High Very High Very High
Disease 266 99.62 Very High Very High Very High
Obesity 191 99.62 Very High Very High Very High
Growth Problems 34 99.60 Very High Very High Very High
Cancer 314 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Context: Short stature in children may be associated with low IGF-I despite normal stimulated GH levels and without other causes.
IGF-I Binding (associated) of associated with growth problems
1) Confidence 0.48 Published 2010 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 19880790 Disease Relevance 0.10 Pain Relevance 0
Treatment with glucocorticoids can be associated with IGF-1 resistance [43,44,46], similar to insulin resistance, which may explain the negative correlation in the P-group.
IGF-1 Binding (associated) of associated with insulin resistance
2) Confidence 0.44 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.30 Pain Relevance 0
The insulin-like growth factor binding protein-3 (IGFBP-3) is the main carrier protein binding to IGF-I in plasma, thus determining its bioavailability.
insulin-like growth factor Binding (binding) of in plasma associated with bioavailability
3) Confidence 0.41 Published 2010 Journal Thyroid Res Section Body Doc Link PMC2858102 Disease Relevance 0.09 Pain Relevance 0.05
DHA may have a role in modulating IGF-I binding in retinal cells (Yorek et al 1989).
IGF-I Binding (binding) of
4) Confidence 0.40 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.87 Pain Relevance 0.09
In particular exogenous administration of rhIGF1 probably does not restore the local IGF-1 action and the paracrine effect of IGF-1 on condrocyte proliferation within the growth plate.32
IGF-1 Binding (action) of in growth plate
5) Confidence 0.37 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0 Pain Relevance 0
Preliminary uncontrolled studies, on treatment of IGFD with the complexes of IGF1/IGFBP-3 (mecasermin rinfabate), showed extension of serum IGF-1 half life and normalization of serum levels of IGF1, but failed to demonstrate an improvement in growth rate, compared to treatment with rhIGF1 alone.17,34
IGF1 Binding (complexes) of
6) Confidence 0.37 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.09 Pain Relevance 0
Preliminary uncontrolled studies, on treatment of IGFD with the complexes of IGF1/IGFBP-3 (mecasermin rinfabate), showed extension of serum IGF-1 half life and normalization of serum levels of IGF1, but failed to demonstrate an improvement in growth rate, compared to treatment with rhIGF1 alone.17,34
IGF1 Binding (normalization) of
7) Confidence 0.37 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0.08 Pain Relevance 0
The comparable levels of circulating IGF-1 either in patients treated with rhIGF1 alone or with the complex, may be explained by the possible binding of IGF-1 to other IGFBPs.
IGF-1 Binding (binding) of
8) Confidence 0.37 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0 Pain Relevance 0
The comparable levels of circulating IGF-1 either in patients treated with rhIGF1 alone or with the complex, may be explained by the possible binding of IGF-1 to other IGFBPs.
IGF-1 Binding (binding) of
9) Confidence 0.37 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724186 Disease Relevance 0 Pain Relevance 0
The combination of GH/IGF-I was much more potent in improving nitrogen balance.
IGF-I Binding (combination) of
10) Confidence 0.37 Published 1993 Journal Horm. Res. Section Abstract Doc Link 8300052 Disease Relevance 0.25 Pain Relevance 0.08
Another approach was described by De Ceuninck et al [55], who noted that disruption of IGF-1 binding to the inhibitory binding proteins via small molecules, resulting in the release of free IGF-1, restores the anabolic response of human chondrocytes.
IGF-1 Binding (binding) of in chondrocytes
11) Confidence 0.37 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.15 Pain Relevance 0.08
With the appreciation that increased levels of IGF-1 binding proteins have been observed in osteoarthritic cartilage [57] one needs to consider if the optimal approach is to raise circulating IGF-1 levels or alternatively promote local production in an autocrine manner.
IGF-1 Binding (binding) of in cartilage associated with osteoarthritis
12) Confidence 0.37 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.16 Pain Relevance 0.06
Assays for growth hormone, its receptors, IGF-I and its binding proteins were developed.
IGF-I Binding (binding) of
13) Confidence 0.36 Published 2008 Journal Pituitary Section Body Doc Link PMC2712620 Disease Relevance 0.53 Pain Relevance 0.05
304), suggesting an interaction between ethosuximide and insulin/IGF-1 signaling.
IGF-1 Binding (interaction) of
14) Confidence 0.36 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2565500 Disease Relevance 0.13 Pain Relevance 0
IGF-1 in serum was determined by radioimmunoassay (RIA) after separation of IGFs from its regulating binding proteins (IGFBPs) by acid ethanol extraction and cryoprecipitation.
IGF Binding (binding) of
15) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.09 Pain Relevance 0.03
Logistic regression models were used to determine the association between IGF measures and CWP.
IGF Binding (association) of
16) Confidence 0.36 Published 2009 Journal J. Rheumatol. Section Body Doc Link 19833751 Disease Relevance 0.08 Pain Relevance 0
The administration of IGF-1 for 3 days decreased protein oxidation and, when administered along with its binding protein, IGF binding protein-3, attenuated catabolism in burn patients [79,81].
IGF Binding (binding protein) of associated with burns
17) Confidence 0.36 Published 1999 Journal Crit Care Section Body Doc Link PMC137235 Disease Relevance 0.55 Pain Relevance 0.04
Their secretion is stimulated by growth hormone and their bioavailability is modified by IGF binding proteins.
IGF Binding (binding) of associated with bioavailability
18) Confidence 0.36 Published 1999 Journal Crit Care Section Body Doc Link PMC137235 Disease Relevance 0.52 Pain Relevance 0.05
Also, Insulin increases IGF-I bioavailability through IGFBP-1 suppression [14,18,19].
IGF-I Binding (bioavailability) of associated with bioavailability
19) Confidence 0.35 Published 2007 Journal BMC Endocr Disord Section Body Doc Link PMC2151943 Disease Relevance 0.79 Pain Relevance 0.05
Medical literature suggests that well controlled biochemical and genetic studies are required to establish the link between insulin, IGF-1, diabetes and cancer.
IGF-1 Binding (link) of associated with cancer and diabetes mellitus
20) Confidence 0.35 Published 2007 Journal BMC Endocr Disord Section Body Doc Link PMC2151943 Disease Relevance 0.84 Pain Relevance 0.04

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