INT16131

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Context Info
Confidence 0.30
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 37
Total Number 37
Disease Relevance 10.32
Pain Relevance 8.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GBE1) generation of precursor metabolites and energy (GBE1) small molecule metabolic process (GBE1)
transferase activity, transferring glycosyl groups (GBE1) carbohydrate metabolic process (GBE1)
Anatomy Link Frequency
plasma 1
muscle 1
brain 1
central nervous system 1
spermatozoa 1
GBE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 15 100.00 Very High Very High Very High
fluoxetine 3 99.96 Very High Very High Very High
cINOD 28 99.84 Very High Very High Very High
narcan 7 99.84 Very High Very High Very High
Pain 26 99.44 Very High Very High Very High
Cholecystokinin 4 99.32 Very High Very High Very High
Chronic pancreatitis 3 99.18 Very High Very High Very High
aspirin 11 99.02 Very High Very High Very High
Enkephalin 6 99.00 Very High Very High Very High
antidepressant 1 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 3 100.00 Very High Very High Very High
Anxiety Disorder 1 99.92 Very High Very High Very High
INFLAMMATION 23 99.72 Very High Very High Very High
Lysosome Storage Disease 8 99.62 Very High Very High Very High
Pain 29 99.44 Very High Very High Very High
Myalgia 3 99.40 Very High Very High Very High
Pancreatitis 3 99.18 Very High Very High Very High
Rhabdomyolysis 11 98.76 Very High Very High Very High
Fabry Disease 148 98.66 Very High Very High Very High
Disease 134 98.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Assessment of enzyme induction and enzyme inhibition in humans: toxicological implications.
Negative_regulation (inhibition) of enzyme
1) Confidence 0.30 Published 1990 Journal Xenobiotica Section Title Doc Link 2275213 Disease Relevance 0 Pain Relevance 0.08
The principal methods used for the assessment of enzyme induction and enzyme inhibition are measurement of the pharmacokinetics of a model compound (probe drug), analysis of drug metabolism in vitro, and determination of changes in the disposition of, and endogenous substrate for, the enzyme of interest. 2.
Negative_regulation (inhibition) of enzyme
2) Confidence 0.30 Published 1990 Journal Xenobiotica Section Abstract Doc Link 2275213 Disease Relevance 0 Pain Relevance 0.07
A typical bell-shaped inhibition curve was observed for the formation of 1-naphthol glucuronides, indicating substrate or product inhibition of the UGT enzyme(s) at higher 1-naphthol concentrations (200 microM and 500 microM).
Negative_regulation (inhibition) of enzyme
3) Confidence 0.22 Published 2010 Journal Int J Pharm Section Abstract Doc Link 19733645 Disease Relevance 0 Pain Relevance 0.32
These include, tianeptine (affects structural plasticity in hippocampus and is an effective antidepressant); phenytoin (antiseizure and neuroprotective); fluoxetine (downregulates neurodegenerative enzyme and increases neuroprotective hippocampal S100 beta); lithium (neuroprotective and antiapoptotic); tricyclic antidepressants (increase hippocampal neurogenesis); antipsychotics (reduce hippocampal neuronal suppression); sodium valproate (increases neurogenesis) and mifepristone (antioxidant, neuroprotective and anti-glucocorticoid).
Negative_regulation (downregulates) of enzyme in hippocampus associated with antidepressant, hippocampus, neurodegenerative disease, tricyclic antidepressant and fluoxetine
4) Confidence 0.17 Published 2007 Journal Med. Hypotheses Section Abstract Doc Link 17098374 Disease Relevance 1.90 Pain Relevance 0.45
Inhibition of the prostaglandin synthetic enzyme, cyclooxygenase, by nonsteroidal anti-inflammatory drugs (NSAIDs), is associated with increased gastroduodenal mucosal damage and ulceration.
Negative_regulation (Inhibition) of enzyme associated with inflammation and cinod
5) Confidence 0.17 Published 1991 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 1940199 Disease Relevance 0.31 Pain Relevance 0.42
APBD should be suspected when patients present with late onset of progressive disease in the peripheral and central nervous system, such as progressive sensorimotor or pure motor peripheral neuropathy, upper motor neuron symptoms, neurogenic bladder, and cognitive impairment.1-6 Its most consistent features are onset within the fifth to seventh decade (88%), peripheral neuropathy (80%), dementia (64%), neurogenic bladder (72%), and upper motor neuron sign (80%), although most patients have one or more of these features missing, and some rarer clinical phenomena have been noted.4 Familial clustering is observed in 30% of cases,3 and the pathogenesis is known as glycogen branching enzyme deficiency.1 Genetic analysis of some Ashkenazi Jewish families and non-Jewish individuals with APBD have identified mutations, but recent reports have also described reduced glycogen branching enzyme activity as an important factor for APBD patients.1 Polyglucosan bodies could be confirmed with a sural nerve biopsy 3,5; some reports showed a skin biopsy also appears to be a simple, reliable, and less invasive diagnostic tool.3 Our patient was confirmed by pathological findings in the peripheral nerves of vastus lateralis muscles.
Negative_regulation (reduced) of branching enzyme in central nervous system associated with cognitive disorder, dementia, urinary dysfunction, amylopectinosis, peripheral neuropathy, central nervous system and disease
6) Confidence 0.17 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628064 Disease Relevance 1.19 Pain Relevance 0.16
Enzyme inhibitors, for instance nonsteroidal antiinflammatory drugs (NSAIDs), exert a strong tumoristatic effect.
Negative_regulation (inhibitors) of Enzyme associated with inflammation and cinod
7) Confidence 0.11 Published 1995 Journal Toxicol. Lett. Section Abstract Doc Link 8597161 Disease Relevance 0.46 Pain Relevance 0.28
These studies indicate that in humans, the predominant enzyme catalyzing the dehydrogenation of long-chain acyl-CoA esters is membrane-bound and that deficiency of this enzyme is a cause of muscle pain and rhabdomyolysis.
Negative_regulation (deficiency) of enzyme in muscle associated with pain, rhabdomyolysis and myalgia
8) Confidence 0.11 Published 1994 Journal Neurology Section Abstract Doc Link 8145917 Disease Relevance 0.39 Pain Relevance 0.16
Neither enantiomers activated, but rather inhibited the enzyme, with Met replacing Arg-276 which has been shown to interact with the 2'-phosphate of NADP+.
Negative_regulation (inhibited) of enzyme
9) Confidence 0.08 Published 1998 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9853403 Disease Relevance 0.13 Pain Relevance 0.16
The inhibitions of the mutant enzyme by R- and S-ibuprofens were competitive with respect to the substrate, giving Ki values of 95 and 18 microM, respectively.
Negative_regulation (inhibitions) of enzyme
10) Confidence 0.08 Published 1998 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9853403 Disease Relevance 0.07 Pain Relevance 0.11
Effect of captopril, an inhibitor of the converting enzyme on naloxone induced secretion of ACTH and LH in man.
Negative_regulation (inhibitor) of enzyme associated with narcan
11) Confidence 0.04 Published 1993 Journal Horm. Metab. Res. Section Title Doc Link 8262463 Disease Relevance 0.08 Pain Relevance 0.80
The present work aims at evaluating whether ASA could directly decrease cell glycolysis through inhibition of the major regulatory enzyme within this pathway, 6-phosphofructo-1-kinase (PFK).
Negative_regulation (inhibition) of enzyme associated with aspirin
12) Confidence 0.04 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 18851958 Disease Relevance 0.49 Pain Relevance 0.39
An inhibitory effect of beta-carbolines and of 3,4-dihydro-beta-carbolines on this enzyme 'in vitro' is reported.
Negative_regulation (effect) of enzyme
13) Confidence 0.04 Published 1983 Journal Biosci. Rep. Section Abstract Doc Link 6301578 Disease Relevance 0 Pain Relevance 0.26
Since some beta-carboline derivatives have recently been shown to possess high affinity for benzodiazepine receptors in brain, the action of diazepam on the aminopeptidase activity was tested and a relevant inhibition of the human enzyme could be demonstrated.
Negative_regulation (inhibition) of enzyme in brain
14) Confidence 0.04 Published 1983 Journal Biosci. Rep. Section Abstract Doc Link 6301578 Disease Relevance 0 Pain Relevance 0.23
The CYP2D6.10 enzyme was the most impaired, exhibiting an estimated enzyme efficiency (as V(max)/K(m)) 50-fold lower for DXM O-demethylation and 100-fold lower for fluoxetine N-demethylation when compared with CYP2D6.1, whereas no measurable catalytic activity was observed for this variant toward codeine.
Negative_regulation (impaired) of enzyme associated with dextromethorphan, codeine and fluoxetine
15) Confidence 0.02 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438554 Disease Relevance 0 Pain Relevance 0.61
A common polymorphism in methionine synthase reductase, MTRR 66A>G, is associated with reduced enzyme activity.
Negative_regulation (reduced) of enzyme
16) Confidence 0.02 Published 2009 Journal Pharmacogenet. Genomics Section Abstract Doc Link 19339913 Disease Relevance 0 Pain Relevance 0.16
Anti-inflammatory drugs highly inhibited the enzyme.
Negative_regulation (inhibited) of enzyme associated with inflammation and cinod
17) Confidence 0.02 Published 1998 Journal J. Biochem. Section Abstract Doc Link 9792917 Disease Relevance 0.10 Pain Relevance 0.10
The enzyme was strongly inhibited by the Kunitz inhibitor domain peptide of Alzheimer's disease amyloid protein precursor (Ki value, 0.35 nM) and by the microbial inhibitors leupeptin and anti-pain.
Negative_regulation (inhibited) of enzyme associated with pain, alzheimer's dementia and disease
18) Confidence 0.02 Published 1993 Journal Gerontology Section Abstract Doc Link 8365670 Disease Relevance 0.59 Pain Relevance 0.09
The microsomal enzyme activity was inhibited by steroids, lithocholic acid and indomethacin.
Negative_regulation (inhibited) of enzyme
19) Confidence 0.01 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15997113 Disease Relevance 0 Pain Relevance 0.62
The presence of such a feedback mechanism in chronic pancreatitis patients with exocrine enzyme deficiency possibly leads to an increase in cholecystokinin plasma levels.
Negative_regulation (deficiency) of enzyme in plasma associated with somatostatin, cholecystokinin and chronic pancreatitis
20) Confidence 0.01 Published 2000 Journal Hepatogastroenterology Section Abstract Doc Link 10919050 Disease Relevance 0.36 Pain Relevance 0.62

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