INT161322

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.65
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PTEN) cell proliferation (PTEN) cytosol (PTEN)
plasma membrane (PTEN) nucleus (PTEN) enzyme binding (PTEN)
Anatomy Link Frequency
arm 1
PTEN (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 108 97.24 Very High Very High Very High
antagonist 23 92.96 High High
Arthritis 68 77.96 Quite High
Inflammation 43 77.56 Quite High
psoriasis 10 72.12 Quite High
headache 4 66.44 Quite High
spinal inflammation 62 50.00 Quite Low
agonist 6 50.00 Quite Low
palliative 3 47.16 Quite Low
methotrexate 106 43.16 Quite Low
Disease Link Frequency Relevance Heat
Cancer 249 100.00 Very High Very High Very High
Renal Cancer 27 99.68 Very High Very High Very High
Rheumatoid Arthritis 108 97.24 Very High Very High Very High
Endometrial Cancer 173 95.68 Very High Very High Very High
Congenital Anomalies 6 95.36 Very High Very High Very High
Disease 85 94.20 High High
Subependymal Glioma 31 92.56 High High
Primitive Neuroectodermal Tumors 2 83.32 Quite High
Arthritis 8 77.96 Quite High
Papillomavirus Infection 127 77.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutation analysis did not show any variation in INI-1 and PTEN sequence while P53 analysis showed the presence of homozygote P72R variation.
Localization (sequence) of PTEN
1) Confidence 0.73 Published 2010 Journal Neuropathology Section Abstract Doc Link 19563506 Disease Relevance 0.80 Pain Relevance 0.07
They are associated with a number of well-described genetic alterations including mutations of PTEN, KRAS, ?
Localization (mutations) of PTEN
2) Confidence 0.72 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.23 Pain Relevance 0
Screening of the tumor related genes: PTEN, TP53 and SOX2
Localization (Screening) of PTEN associated with cancer
3) Confidence 0.65 Published 2010 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2991767 Disease Relevance 0.69 Pain Relevance 0
On the opposite, the presence of a mutated PTEN protein enables Akt phosphorylation, which in turn may phosphorylate I?
Localization (presence) of PTEN
4) Confidence 0.53 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.23 Pain Relevance 0
of IkB, induction of TSC22, NF-kB, GADD153, PTEN, etc.) may depend on the
Localization (etc.) of PTEN
5) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.79 Pain Relevance 0
therapy and discontinued for any reason, GLM significantly reduced signs and symptoms of RA and improved physical function at week 24 as assessed by ACR20, ACR50, and improvement in HAQ scores (P <0.001 for all measures for each GLM treatment arm compared individually with placebo).25 Among patients who had discontinued prior TNF-?
Localization (arm) of GLM in arm associated with rheumatoid arthritis
6) Confidence 0.10 Published 2010 Journal Core evidence Section Body Doc Link PMC2899784 Disease Relevance 0.30 Pain Relevance 0.23
The histidine buffer formulation and GLM concentration were chosen to minimize discomfort on injection, which had been reported by patients to whom larger volumes of other biologic agents dissolved in citrate buffer were administered.17,18

Pharmacokinetics

Localization (concentration) of GLM
7) Confidence 0.10 Published 2010 Journal Core evidence Section Body Doc Link PMC2899784 Disease Relevance 0.61 Pain Relevance 0.27
A substantial study of 375 patients investigated the prognostic significance of mTOR pathway components in tumors obtained at nephrectomy, and observed adverse prognostic impact on disease-specific survival of pS6K, PTEN and Akt independent of stage.73 A small study further suggested that pS6K and possibly Akt were predictors of response to temsirolimus for advanced RCC.67,74 However an extension of the study20 of temsirolimus for poor prognosis advanced RCC did not find a correlation between PTEN and HIF-1?
Localization (correlation) of PTEN associated with cancer, renal cancer and disease
8) Confidence 0.10 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880340 Disease Relevance 0.65 Pain Relevance 0
GLM has a MA in social anthropology and is specialised in medical anthropology.
Localization (specialised) of GLM
9) Confidence 0.05 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2989980 Disease Relevance 0.35 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox