INT161355

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 10
Disease Relevance 0.70
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nes) intracellular (Nes) cytoplasm (Nes)
Anatomy Link Frequency
stem cell 3
pancreas 1
stem 1
Nes (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 18 96.28 Very High Very High Very High
Chronic pancreatitis 2 50.00 Quite Low
alcohol 54 22.64 Low Low
cerebral cortex 36 5.00 Very Low Very Low Very Low
addiction 18 5.00 Very Low Very Low Very Low
ketamine 9 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
Neurotransmitter 9 5.00 Very Low Very Low Very Low
tolerance 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 89.00 High High
Neuropathic Pain 3 85.40 High High
Apoptosis 171 70.88 Quite High
Fetal Alcohol Syndrome 54 64.12 Quite High
Pancreatic Cancer 4 50.00 Quite Low
Pancreatitis 2 50.00 Quite Low
Neurodegenerative Disease 54 5.00 Very Low Very Low Very Low
Death 45 5.00 Very Low Very Low Very Low
Genomic Instability 36 5.00 Very Low Very Low Very Low
Cancer 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, semi-quantitative RT-PCR analysis (Figure 7B) showed that there was no change in nestin mRNA expression (normalized to cyclophilin-A) following ethanol exposure.
Transcription (expression) of nestin
1) Confidence 0.18 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
Ethanol suppresses cell-surface stem cell marker expression but not nestin mRNA expression in neurospheres
Transcription (expression) of nestin in stem cell
2) Confidence 0.18 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
These data suggest that while ethanol may not decrease the overall size of the precursor pool (the combined stem and blast pool, indicated by constant nestin mRNA expression), it decreases the diversity of stem cells within this pool (indicated by decreased numbers of cells expressing Sca-1, c-kit, CD133 and ABCG2).


Transcription (expression) of nestin in stem
3) Confidence 0.18 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
TERT and nestin mRNA levels were quantified by densitometric measurement, and were expressed as a ratio of cyclophilin-A mRNA expression (Molecular Analyst for Windows, BioRad).
Transcription (levels) of nestin
4) Confidence 0.18 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
TERT and nestin mRNA levels were quantified by densitometric measurement, and were expressed as a ratio of cyclophilin-A mRNA expression (Molecular Analyst for Windows, BioRad).
Transcription (expressed) of nestin
5) Confidence 0.17 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
We hypothesized that if ethanol suppressed the expression of cell-surface stem cell markers, it would similarly suppress the expression of mRNA for nestin.
Transcription (expression) of nestin in stem cell
6) Confidence 0.17 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
Nestin mRNA was also expressed in cultured cortical precursors, but nestin mRNA levels did not change with ethanol exposure, indicating that despite maturational pressure, immature, possibly blast-type cells continue to persist in ethanol-treated cultures.
Transcription (levels) of nestin
7) Confidence 0.13 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.18 Pain Relevance 0.09
However nestin mRNA expression is not informative about the extent to which ethanol affects the heterogeneity of stem cells in culture, because nestin expression is a common phenotype of stem and more differentiated blast cells.
Transcription (expression) of nestin in stem cells
8) Confidence 0.13 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.18 Pain Relevance 0.08
Nestin mRNA was also expressed in cultured cortical precursors, but nestin mRNA levels did not change with ethanol exposure, indicating that despite maturational pressure, immature, possibly blast-type cells continue to persist in ethanol-treated cultures.
Transcription (expressed) of Nestin
9) Confidence 0.13 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.18 Pain Relevance 0.09
METHODS: Pancreatic nerve fiber qualities were characterized by immunohistochemical visualization of various markers, including those for sympathetic (tyrosine hydroxylase, TH) and cholinergic innervation (choline acetyltransferase, ChAT), as well as the glial transcription factor, Sox10, and the neuroepithelial progenitor cell marker, Nestin, in normal pancreas (NP, n=16), CP (n=20), and PCa (n=20) patients.
Transcription (transcription factor) of Nestin in pancreas
10) Confidence 0.07 Published 2009 Journal Am. J. Gastroenterol. Section Body Doc Link 19568227 Disease Relevance 0.09 Pain Relevance 0

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