INT161376

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Context Info
Confidence 1.00
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.92
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNI3) cytoplasm (TNNI3)
Anatomy Link Frequency
cardiomyocytes 1
bands 1
TNNI3 (Homo sapiens)
Pain Link Frequency Relevance Heat
iatrogenic 7 96.36 Very High Very High Very High
ischemia 11 90.28 High High
cva 15 87.68 High High
Pain 7 87.28 High High
depression 2 47.32 Quite Low
cytokine 5 22.60 Low Low
Inflammation 10 17.80 Low Low
Angina 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 13 99.40 Very High Very High Very High
Hypertrophic Cardiomyopathy 14 98.92 Very High Very High Very High
Necrosis 24 98.84 Very High Very High Very High
Myocardial Infarction 60 98.56 Very High Very High Very High
Cv General 4 Under Development 7 90.28 High High
Pulmonary Embolism 10 88.48 High High
Pain 7 87.28 High High
Hypertension 1 75.36 Quite High
Sepsis 11 70.44 Quite High
Right Ventricular Dysfunction 2 64.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here the iatrogenic induction of myocardial necrosis occurs in vivo, allowing us to investigate degradation of cTnI by the second.
Spec (investigate) Protein_catabolism (degradation) of cTnI associated with necrosis
1) Confidence 1.00 Published 2009 Journal Cardiology Section Abstract Doc Link 19571537 Disease Relevance 0.60 Pain Relevance 0.14
Western blot analysis was performed with subsequent analysis of relative intensities of the bands as compared to the degradation of cTnI in STEMI patients from the ASSENT-2 troponin substudy.
Protein_catabolism (degradation) of cTnI in bands
2) Confidence 1.00 Published 2009 Journal Cardiology Section Body Doc Link 19571537 Disease Relevance 0.09 Pain Relevance 0
We have recently described the appearance of intact cardiac troponin I (cTnI) and 7 degradation products in patients suffering from ST-elevation myocardial infarction (STEMI) using Western blot analysis.
Protein_catabolism (degradation) of cTnI associated with myocardial infarction
3) Confidence 0.88 Published 2009 Journal Cardiology Section Abstract Doc Link 19571537 Disease Relevance 0.50 Pain Relevance 0.12
Cardiac troponin I degradation in serum of patients with hypertrophic obstructive cardiomyopathy undergoing percutaneous septal ablation.
Protein_catabolism (degradation) of troponin I associated with hypertrophic cardiomyopathy
4) Confidence 0.87 Published 2009 Journal Cardiology Section Title Doc Link 19571537 Disease Relevance 0.49 Pain Relevance 0.11
It is postulated that a transient (reversible) increase in membrane permeability of the cardiomyocytes in SRMD, together with intracellular degradation of troponin I, was responsible for the increased cTn levels [78,79].
Protein_catabolism (degradation) of troponin I in cardiomyocytes associated with coronary heart disease
5) Confidence 0.70 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.59 Pain Relevance 0.19
CONCLUSION: This work describes the degradation products of troponin I in HOCM patients undergoing PTSMA.
Protein_catabolism (degradation) of troponin I
6) Confidence 0.66 Published 2009 Journal Cardiology Section Body Doc Link 19571537 Disease Relevance 0.07 Pain Relevance 0
We have recently described the appearance of intact cardiac troponin I (cTnI) and 7 degradation products in patients suffering from ST-elevation myocardial infarction (STEMI) using Western blot analysis.
Protein_catabolism (degradation) of troponin I associated with myocardial infarction
7) Confidence 0.57 Published 2009 Journal Cardiology Section Abstract Doc Link 19571537 Disease Relevance 0.50 Pain Relevance 0.12
RESULTS: We demonstrate intact cTnI and 9 degradation products [molecular weight (MW) 12.0-23.5 kDa].
Protein_catabolism (degradation) of cTnI
8) Confidence 0.57 Published 2009 Journal Cardiology Section Body Doc Link 19571537 Disease Relevance 0.08 Pain Relevance 0

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