INT161379

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 11.05
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl)
cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)
Anatomy Link Frequency
neuronal 2
endothelial cells 2
lymphocyte 1
apoptotic cell 1
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 200 100.00 Very High Very High Very High
Dopamine 122 99.04 Very High Very High Very High
abdominal pain 1 92.24 High High
Inflammation 218 92.08 High High
dopaminergic neurodegeneration 2 91.60 High High
rheumatoid arthritis 144 80.00 Quite High
Inflammatory mediators 8 79.92 Quite High
chemokine 35 70.32 Quite High
Central nervous system 49 46.40 Quite Low
Inflammatory response 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 280 100.00 Very High Very High Very High
Death 44 99.32 Very High Very High Very High
Necrosis 13 98.74 Very High Very High Very High
Cancer 22 98.56 Very High Very High Very High
Apoptosis 125 97.84 Very High Very High Very High
Parkinson's Disease 41 94.84 High High
Encephalitis 15 94.72 High High
Abdominal Pain 1 92.24 High High
INFLAMMATION 262 92.08 High High
Mycobacterial Infection 290 91.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In recent studies, endothelial cells were reported to constitutively express FasL and release soluble FasL [29-31].
Localization (release) of FasL in endothelial cells
1) Confidence 0.67 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.40 Pain Relevance 0.29
In recent studies, endothelial cells were reported to constitutively express FasL and release soluble FasL [29-31].
Localization (release) of FasL in endothelial cells
2) Confidence 0.67 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.40 Pain Relevance 0.29
In this study, we have clearly shown the degree of cell death, assessed by immunohistochemical localization of FasL and TUNEL staining, which highlights the presence of apoptotic cell bodies.
Localization (localization) of FasL in apoptotic cell associated with apoptosis and death
3) Confidence 0.63 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 1.09 Pain Relevance 0.04
FasL and IL-2R were upregulated in the beginning of infection and deceased further.
Localization (deceased) of FasL associated with infection
4) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797643 Disease Relevance 1.01 Pain Relevance 0.11
However, in this study, CD4+ T cell-mediated DA neuronal loss was found to be dependent on the presence of the TNF ligand family member, FasL, and not IFN-?.
Localization (presence) of FasL in neuronal associated with dopamine
5) Confidence 0.43 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.82 Pain Relevance 0.32
However, in this study, CD4+ T cell-mediated DA neuronal loss was found to be dependent on the presence of the TNF ligand family member, FasL, and not IFN-?.
Localization (presence) of TNF ligand family member in neuronal associated with dopamine
6) Confidence 0.43 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.82 Pain Relevance 0.32
pathway, such as Tumor necrosis factor alpha-induced protein 2 (TNFAIP2), tumor necrosis factor receptor superfamily member 1b (TNFRSF1B), Fas ligand (FASL) and lymphotoxin (LTB) were all induced at D21 and showed a positive correlation with TNF?
Localization (showed) of FASL associated with necrosis, cancer and infection
7) Confidence 0.27 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 2.03 Pain Relevance 0
pathway, such as Tumor necrosis factor alpha-induced protein 2 (TNFAIP2), tumor necrosis factor receptor superfamily member 1b (TNFRSF1B), Fas ligand (FASL) and lymphotoxin (LTB) were all induced at D21 and showed a positive correlation with TNF?
Localization (lymphotoxin) of FASL associated with necrosis, cancer and infection
8) Confidence 0.27 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.90 Pain Relevance 0
Different lymphocyte subsets were quantified on the basis of surface antigen expression (CD3, CD4, CD8, CD20), secreted cytokines (IL-4, IL-6, IFNgamma) and Fas and FasL proteins in the gastric mucosa.
Localization (secreted) of FasL in lymphocyte associated with cytokine
9) Confidence 0.16 Published 2009 Journal Acta Biochim. Pol. Section Abstract Doc Link 19572057 Disease Relevance 0.58 Pain Relevance 0.19

General Comments

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