INT161382
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
It is generally accepted that the CD20 protein functions as a channel regulator of ion influx (Ernst et al 2005) and that this membrane-bound protein is specifically found on the membrane of B-cells but is not expressed on stem cells nor on terminally-differentiated plasma cells. | |||||||||||||||
| |||||||||||||||
|
Still, not all CD19+ B-cells were eliminated in bone marrow as pre-B-cells and CD20? | |||||||||||||||
| |||||||||||||||
|
Furthermore, residual RTX remains in patients serum for three to six months after treatment and could potentially block CD20 binding sites.46 Preclinical studies using human lymphoma cell lines, patient-derived specimens, and mouse xenograft models have shown that prior RTX therapy reduces CD20 binding, tumor-specific localization, and tumor control for 131I-TST.46 Despite this preclinical data, 131I-TST has been shown to be clinically effective in RTX-refractory relapsed low grade B-cell NHL as discussed previously.31 Future clinical studies should help determine whether inclusion of RTX in induction chemotherapy regimens abrogates the incremental therapeutic gain of consolidation 131I-TST found in the studies listed in Table 4.
| |||||||||||||||
| |||||||||||||||
|
In the group of patients suspected of CTD, the frequency of CD27++/CD20? | |||||||||||||||
| |||||||||||||||
|
In the healthy control group, the mean frequency of CD27++/CD20? | |||||||||||||||
| |||||||||||||||
|
Whether complete depletion of peripheral B-cells and remaining CD20- plasmablasts may be used as a biomarker of clinical response needs further careful analysis in RA. | |||||||||||||||
| |||||||||||||||
|
PBMCs and BAL cells were stained with antibodies directed against CD20, IgD and CD27 to distinguish between three subsets: CD27-IgD+ (most likely naïve), CD27+IgD+, and CD27+IgD? | |||||||||||||||
| |||||||||||||||
|
The syndecan-1 positive cells did not co-localise with CD20 indicating that they were not immature or mature B cells (fig 2C,D). | |||||||||||||||
| |||||||||||||||
|
For co-localisation of syndecan-1 and CD20, sections were treated with anti-syndecan-1 (5 ? | |||||||||||||||
| |||||||||||||||
|
No co-localisation was observed between CCR9 and CD20 (B lymphocytes) or CD3 (T lymphocytes) respectively in either RA or non-RA synovia (data not shown). | |||||||||||||||
| |||||||||||||||
|
The antibodies used for lineage-specific markers included CD3 (clone SP34-2), CD4 (clone L200), CD8 (clone RPA-T8), CD14 (clone M5E2), CD13 (clone L138), CD20 (clone L27), and CD34 (clone 563). | |||||||||||||||
| |||||||||||||||
|
These studies are often focused on specific protein families, such as G-protein coupled receptors (8), nuclear receptors (9) and kinases (10), but global pharmacology profiles of chemicals are considered as well (1,2). | |||||||||||||||
| |||||||||||||||
|
These studies are often focused on specific protein families, such as G-protein coupled receptors (8), nuclear receptors (9) and kinases (10), but global pharmacology profiles of chemicals are considered as well (1,2). | |||||||||||||||
| |||||||||||||||
|
Two-dimensional gel protein separation of extracts from cultured human corneal endothelial cells | |||||||||||||||
| |||||||||||||||
|
Protein sample preparation | |||||||||||||||
| |||||||||||||||
|
Different lymphocyte subsets were quantified on the basis of surface antigen expression (CD3, CD4, CD8, CD20), secreted cytokines (IL-4, IL-6, IFNgamma) and Fas and FasL proteins in the gastric mucosa. | |||||||||||||||
| |||||||||||||||
|
-Synuclein is a relatively small (112140 amino acids in length) presynaptic nonsecreting protein and makes up around 1% of the total protein within the brain and less than 0.001% of the CSF proteome [37]. | |||||||||||||||
| |||||||||||||||
|
Recent studies indicate that pp71 stimulates the release of ATRX, a cell protein with chromatin remodelling activity, from ND10 in a very early event after infection, suggesting that ATRX is an important component of the cellular intrinsic defences to HCMV [21]. | |||||||||||||||
| |||||||||||||||
|
This protein is found in the cytoplasm, where it regulates apoptosis [8,9], and also in nuclear structures known as nuclear domain 10 (ND10) [10-12]. | |||||||||||||||
| |||||||||||||||
|
The samples were positive for anti-BCL-2, CD10, CD20 and CD68 antibodies and negative for CD3 (in the follicles). | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.