INT1614

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Context Info
Confidence 0.78
First Reported 1979
Last Reported 2010
Negated 2
Speculated 6
Reported most in Abstract
Documents 164
Total Number 170
Disease Relevance 31.43
Pain Relevance 127.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 15
neurons 9
dorsal root ganglion 8
ovary 6
NG108-15 6
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 366 100.00 Very High Very High Very High
Opioid 365 100.00 Very High Very High Very High
opioid receptor 309 100.00 Very High Very High Very High
Kappa opioid receptor 233 100.00 Very High Very High Very High
tolerance 211 100.00 Very High Very High Very High
opiate 184 100.00 Very High Very High Very High
agonist 184 100.00 Very High Very High Very High
narcan 89 100.00 Very High Very High Very High
antagonist 68 100.00 Very High Very High Very High
Enkephalin 67 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 7 100.00 Very High Very High Very High
Hyperalgesia 25 99.96 Very High Very High Very High
Sleep Disorders 8 99.96 Very High Very High Very High
Neuroblastoma 12 99.84 Very High Very High Very High
Cancer 3 99.84 Very High Very High Very High
Ganglion Cysts 37 99.56 Very High Very High Very High
Urological Neuroanatomy 48 99.52 Very High Very High Very High
Stress 33 99.48 Very High Very High Very High
Nociception 33 99.26 Very High Very High Very High
Glioma 11 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Expression of opioid-receptor-like receptor (ORL1) gene in rat brain].
Gene_expression (Expression) of opioid-receptor-like receptor in brain associated with pain and opioid
1) Confidence 0.78 Published 1998 Journal Sheng Li Xue Bao Section Title Doc Link 11324527 Disease Relevance 0 Pain Relevance 0.63
In situ hybridization with a digoxigenin-labeled oligonucleotide probe was used to investigate the expression of opioid-receptor-like receptor (ORL1) gene in rat brain.
Spec (investigate) Gene_expression (expression) of opioid-receptor-like receptor in brain associated with opioid
2) Confidence 0.78 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324527 Disease Relevance 0 Pain Relevance 0.50
In situ hybridization with a digoxigenin-labeled oligonucleotide probe was used to investigate the expression of opioid-receptor-like receptor (ORL1) gene in rat brain.
Spec (investigate) Gene_expression (expression) of ORL1 in brain associated with opioid
3) Confidence 0.78 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324527 Disease Relevance 0 Pain Relevance 0.50
[Expression of opioid-receptor-like receptor (ORL1) gene in rat brain].
Gene_expression (Expression) of ORL1 in brain associated with pain and opioid
4) Confidence 0.78 Published 1998 Journal Sheng Li Xue Bao Section Title Doc Link 11324527 Disease Relevance 0 Pain Relevance 0.63
Expression of the neuropeptide orphanin FQ/nociceptin (OFQ/N) and its receptor, the opioid receptor-like receptor (ORL1), have been found to have a wide distribution in the central nervous system, and in brain areas involved in sensory perception in particular.
Gene_expression (Expression) of opioid receptor-like receptor in central nervous system associated with orphanin, neuropeptide, central nervous system and opioid receptor
5) Confidence 0.78 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126889 Disease Relevance 0.08 Pain Relevance 0.48
Expression of the neuropeptide orphanin FQ/nociceptin (OFQ/N) and its receptor, the opioid receptor-like receptor (ORL1), have been found to have a wide distribution in the central nervous system, and in brain areas involved in sensory perception in particular.
Gene_expression (Expression) of ORL1 in central nervous system associated with orphanin, neuropeptide, central nervous system and opioid receptor
6) Confidence 0.78 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126889 Disease Relevance 0.08 Pain Relevance 0.50
We found that OFQ/N and ORL1 mRNA are expressed in DRG; primarily in small and large neurons, respectively.
Gene_expression (expressed) of ORL1 mRNA in neurons
7) Confidence 0.78 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126889 Disease Relevance 0.09 Pain Relevance 0.63
Further, expression of OFQ/N and ORL1 mRNA was also found in SCG, whereas expression was undetectable in skin.
Gene_expression (expression) of ORL1 mRNA in skin
8) Confidence 0.78 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126889 Disease Relevance 0.16 Pain Relevance 0.53
Expression levels of the mRNA for the kappa-opioid receptor, as detected by reverse transcription-polymerase chain reaction followed by Southern blot analysis, were significantly increased in the cerebral cortex, striatum, and midbrain, including thalamus, hippocampus, and pons, in animals dependent on butorphanol.
Gene_expression (Expression) of kappa-opioid receptor in midbrain associated with butorphanol, kappa opioid receptor, hippocampus, thalamus, midbrain and cerebral cortex
9) Confidence 0.78 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16130146 Disease Relevance 0.09 Pain Relevance 1.48
These results suggest that prolonged glucocorticoid receptor (GR) occupation in the neonatal period leads to permanent alterations in ORL1 expression in the LHPA stress axis of the adult rat.
Gene_expression (expression) of ORL1 associated with stress
10) Confidence 0.78 Published 2003 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 14643007 Disease Relevance 0.22 Pain Relevance 0.41
Northern blot analysis demonstrated that kappa-opioid receptor mRNA is expressed in a regionally specific manner in rat brain.
Gene_expression (expressed) of kappa-opioid receptor mRNA in brain associated with kappa opioid receptor
11) Confidence 0.78 Published 1993 Journal FEBS Lett. Section Abstract Doc Link 8103466 Disease Relevance 0 Pain Relevance 0.36
In intact DRG neurons, both NC and ORL1 receptor IR were present in mainly small- and medium-sized neurons, NC IR in 31% and ORL1 receptor IR in 33% of all neuronal profiles.
Gene_expression (present) of ORL1 in DRG associated with dorsal root ganglion and orphanin
12) Confidence 0.77 Published 2006 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16930285 Disease Relevance 1.51 Pain Relevance 1.38
Double labeling with ATF3 revealed expression of NC and ORL1 receptor in intact as well as in injured primary afferent neurons.
Gene_expression (expression) of ORL1 in afferent neurons associated with orphanin
13) Confidence 0.77 Published 2006 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16930285 Disease Relevance 1.37 Pain Relevance 1.27
Data on the expression of NC and ORL1 receptor in dorsal root ganglion (DRG) neurons and on its modulation after nerve injury and inflammation are controversial.
Gene_expression (expression) of ORL1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nervous system injury, inflammation and orphanin
14) Confidence 0.77 Published 2006 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16930285 Disease Relevance 1.17 Pain Relevance 1.14
The results showed: (1) CFA-induced peripheral inflammation evoked robust astrocyte activation and proinflammatory cytokines spinally; (2) down-regulation of cytokine mRNA transcripts by intrathecal administration of N/OFQ, the effects produced by N/OFQ were abolished by combination with ORL1 receptor-specific antagonist [Nphe(1)]N/OFQ(1-13)NH2; (3) ORL1 receptor was expressed on astrocytes of rat spinal cord; (4) cytokine gene expression was inhibited in astrocyte cultures exposed to N/OFQ, the inhibiting effects of N/OFQ were significantly blocked by [Nphe(1)]N/OFQ(1-13)NH2.
Gene_expression (expressed) of ORL1 in astrocytes associated with inflammation, antagonist, spinal cord, intrathecal and cytokine
15) Confidence 0.77 Published 2007 Journal Neuroscience Section Abstract Doc Link 17069983 Disease Relevance 0.74 Pain Relevance 1.03
No significant changes were observed for either the nociceptin precursor or mu-opioid receptor expression.
Gene_expression (expression) of nociceptin precursor associated with orphanin and opioid receptor
16) Confidence 0.77 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12106803 Disease Relevance 0.37 Pain Relevance 0.68
Effects of single and dual administration of cocaine and ethanol on opioid and ORL1 receptor expression in rat CNS: an autoradiographic study.
Gene_expression (expression) of ORL1 receptor associated with opioid and cocaine
17) Confidence 0.77 Published 2003 Journal Brain Res. Section Title Doc Link 12834892 Disease Relevance 0 Pain Relevance 0.89
The results showed that: (1) Intracerebroventricular (i.c.v.) injection of OFQ reversed the stress analgesia induced by i.c.v. injection of normal saline, which seems to be mediated by endogenous opioid peptides. (2) I.c.v. injection of OFQ dose-dependently antagonized morphine-induced analgesia dose-dependently. (3) I.c.v. injection of antisense oligodeoxynucleotide for the gene encoding ORL receptor to block the expression of ORL receptor in the CNS potentiated the analgesia induced by cumulative injection of morphine.
Gene_expression (expression) of ORL receptor associated with stress, endogenous opioid, intracerebroventricular, morphine and analgesia
18) Confidence 0.77 Published 1997 Journal Sheng Li Xue Bao Section Abstract Doc Link 9812820 Disease Relevance 0.17 Pain Relevance 1.35
Based on the high homology of ORL receptor and OFQ with their opioid family counterparts, as well as the high expression of ORL receptor mRNA and protein in the brain areas associated with nociception, the effect of OFQ on morphine induced analgesia in the rat brain was further investigated.
Gene_expression (expression) of ORL receptor in brain associated with nociception, opioid, analgesia and morphine
19) Confidence 0.77 Published 1997 Journal Sheng Li Xue Bao Section Abstract Doc Link 9812820 Disease Relevance 0.18 Pain Relevance 1.08
By using in situ hybridization, cells expressing ORL1 mRNA were most numerous throughout multiple cortical regions, the anterior olfactory nucleus, lateral septum, endopiriform nucleus, ventral forebrain, multiple hypothalamic nuclei, nucleus of the lateral olfactory tract, medial amygdala, hippocampal formation, substantia nigra, ventral tegmental area, central gray, raphe complex, locus coeruleus, multiple brainstem motor nuclei, inferior olive, deep cerebellar nuclei, vestibular nuclear complex, nucleus of the solitary tract, reticular formation, dorsal root ganglia, and spinal cord.
Gene_expression (expressing) of ORL1 mRNA in ventral associated with medulla, ventral tegmentum, locus ceruleus, substantia nigra, raphe, amygdala and spinal cord
20) Confidence 0.76 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10464356 Disease Relevance 0 Pain Relevance 1.11

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