INT161471

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 2009
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 11.47
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Bmi1) nucleus (Bmi1) cytoplasm (Bmi1)
Anatomy Link Frequency
stem cell 3
exocrine cell 2
pancreas 1
acinar cells 1
stem 1
Bmi1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
Chronic pancreatitis 10 85.32 High High
Nerve growth factor 2 65.52 Quite High
Calcium channel 4 35.64 Quite Low
anesthesia 2 34.24 Quite Low
Angina 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mesothelioma 316 100.00 Very High Very High Very High
Metaplasia 5 99.60 Very High Very High Very High
Cancer 257 99.44 Very High Very High Very High
Malignant Neoplastic Disease 40 98.96 Very High Very High Very High
Injury 10 98.32 Very High Very High Very High
Disease 25 96.44 Very High Very High Very High
Targeted Disruption 5 94.60 High High
Adenocarcinoma 30 93.96 High High
Breast Cancer 9 93.28 High High
Solid Tumor 13 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To obtain mechanistic insights, Bmi1 expression in cells undergoing in vitro exocrine cell metaplasia and the effects of Bmi1 depletion in an acinar cancer cell line were studied.
Gene_expression (expression) of Bmi1 in exocrine cell associated with cancer and metaplasia
1) Confidence 0.76 Published 2009 Journal J. Pathol. Section Abstract Doc Link 19585519 Disease Relevance 1.44 Pain Relevance 0.13
Bmi1 expression was induced in acinar cells during acute injury, in acinar-ductal metaplastic lesions, as well as in pancreatic intraepithelial neoplasia (PanIN) and PDAC.
Gene_expression (expression) of Bmi1 in acinar cells associated with adenocarcinoma, cancer and injury
2) Confidence 0.76 Published 2009 Journal J. Pathol. Section Abstract Doc Link 19585519 Disease Relevance 1.43 Pain Relevance 0.06
We found that Bmi1 and Ring1B are expressed in pancreatic exocrine precursor cells during early development and in ductal and islet cells-but not acinar cells-in the adult pancreas.
Neg (not) Gene_expression (expressed) of Bmi1 in pancreas
3) Confidence 0.76 Published 2009 Journal J. Pathol. Section Abstract Doc Link 19585519 Disease Relevance 1.49 Pain Relevance 0.12
To test these ideas, we determined the expression of PRC1 complex proteins (Bmi1 and Ring1b) during pancreatic development and in pancreatic tissue from mouse models of disease: acute and chronic pancreatic injury, duct ligation, and in K-Ras(G12V) conditional knock-in and caerulein-treated K-Ras(G12V) mice.
Spec (determined) Gene_expression (expression) of Bmi1 in duct associated with targeted disruption, injury and disease
4) Confidence 0.76 Published 2009 Journal J. Pathol. Section Abstract Doc Link 19585519 Disease Relevance 1.25 Pain Relevance 0.16
To obtain mechanistic insights, Bmi1 expression in cells undergoing in vitro exocrine cell metaplasia and the effects of Bmi1 depletion in an acinar cancer cell line were studied.
Gene_expression (depletion) of Bmi1 in exocrine cell associated with cancer and metaplasia
5) Confidence 0.66 Published 2009 Journal J. Pathol. Section Abstract Doc Link 19585519 Disease Relevance 1.49 Pain Relevance 0.13
In the eye, SP cells in the cornea localize to the limbal epithelium and have been shown to possess stem cell-like properties, including markedly higher expression levels of Bmi-1, Nes, Notch1, and p63 compared to non-SP cells [7,9].
Gene_expression (expression) of Bmi-1 in stem cell
6) Confidence 0.19 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0.23 Pain Relevance 0.03
In the eye, SP cells in the cornea localize to the limbal epithelium and have been shown to possess stem cell-like properties, including markedly higher expression levels of Bmi-1, Nes, Notch1, and p63 compared to non-SP cells [7,9].
Gene_expression (levels) of Bmi-1 in stem cell
7) Confidence 0.19 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0.23 Pain Relevance 0.03
By real time PCR we found that our cell lines expressed high mRNA levels of typical mesothelioma markers as mesothelin (MSLN) and calretinin (CALB2), and of BMI-1, a stemness marker, and DKK1, a potent Wingless [WNT] inhibitor.


Gene_expression (expressed) of BMI-1 associated with mesothelioma
8) Confidence 0.08 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2850899 Disease Relevance 0.73 Pain Relevance 0
Thus, the inhibitory effect of DKK1 would maintain stemness and inappropriate persistent DKK1 and BMI-1 expression would ultimately lead to malignant transformation, by keeping the cells in an undifferentiated, "stem-like" cellular state.


Gene_expression (expression) of BMI-1 in stem associated with malignant neoplastic disease
9) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2850899 Disease Relevance 0.75 Pain Relevance 0
By real time PCR we found that our cell cultures expressed high mRNA levels of typical mesothelioma markers as mesothelin (MSLN) and calretinin (CALB2), of BMI-1, a stemness marker and of DKK1, a potent Wingless [WNT] inhibitor.
Gene_expression (expressed) of BMI-1 associated with mesothelioma
10) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2850899 Disease Relevance 1.78 Pain Relevance 0
MM cell cultures expressed high mRNA levels of the mesothelioma markers mesothelin (MSLN), calretinin (CALB2), the WNT1 antagonist DKK1 and the stem cell marker BMI-1.
Gene_expression (expressed) of BMI-1 in stem cell associated with mesothelioma and antagonist
11) Confidence 0.07 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2850899 Disease Relevance 0.66 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox