INT161485

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Context Info
Confidence 0.47
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.21
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Il1b, TGFB1) extracellular space (Il1b, TGFB1) extracellular region (Il1b, TGFB1)
enzyme binding (TGFB1) embryo development (TGFB1) cytoplasm (TGFB1)
Anatomy Link Frequency
TMJ 2
Il1b (Mus musculus)
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 4 99.80 Very High Very High Very High
Snapping jaw 5 99.50 Very High Very High Very High
cytokine 1 88.64 High High
Inflammation 3 88.24 High High
Disease Link Frequency Relevance Heat
Osteoarthritis 4 99.80 Very High Very High Very High
Disease 2 99.52 Very High Very High Very High
Temporomandibular Joint Syndrome 5 99.50 Very High Very High Very High
INFLAMMATION 3 88.24 High High
Aging 1 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that a balance between IL-1beta and TGFbeta underlies the development of TMJ osteoarthritis, whereby IL-1beta signaling down-regulates TGFbeta expression as part of disease pathology.
IL-1beta Regulation (regulates) of Gene_expression (expression) of TGFbeta in TMJ associated with snapping jaw, disease and osteoarthritis
1) Confidence 0.47 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19587162 Disease Relevance 1.21 Pain Relevance 0.77

General Comments

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