INT161506

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2006
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.68
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (S100a8) extracellular region (S100a8) plasma membrane (S100a8)
cytoskeleton (S100a8) cytoplasm (S100a8)
Anatomy Link Frequency
macrophage 2
vessels 2
fibroblasts 2
neutrophil 2
S100a8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 166 100.00 Very High Very High Very High
cytokine 74 100.00 Very High Very High Very High
Paracetamol 12 100.00 Very High Very High Very High
chemokine 21 99.40 Very High Very High Very High
fibrosis 10 89.96 High High
headache 1 89.52 High High
ischemia 19 87.28 High High
cINOD 22 71.28 Quite High
metalloproteinase 5 65.48 Quite High
corticosteroid 13 52.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 168 100.00 Very High Very High Very High
Apoptosis 21 98.72 Very High Very High Very High
Toxicity 4 97.28 Very High Very High Very High
Frailty 4 96.24 Very High Very High Very High
Injury 26 94.60 High High
Pulmonary Disease 107 93.76 High High
Chemotherapy-induced Neutropenia 2 90.92 High High
Fibrosis 10 89.96 High High
Headache 1 89.52 High High
Ocular Hypertension 2 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The RT-QPCR analysis confirmed that neutrophil depletion in the mice significantly decreased, but did not completely abrogate the upregulation of the aforementioned genes (including S100A8, S100A9, IL-1?
Regulation (upregulation) of Gene_expression (including) of S100A8 in neutrophil
1) Confidence 0.45 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.50 Pain Relevance 0.12
In summary, the above data shows that the changes of expression of the S100A8 and S100A9 genes, as well as several other cytokines, changed in concert with the growth and atrophy of new vessels in the S-CorNV model.
Regulation (changes) of Gene_expression (expression) of S100A8 in vessels associated with frailty and cytokine
2) Confidence 0.45 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.39 Pain Relevance 0.20
We investigated the effect of subtoxic concentrations of acetaminophen in conjunction with bacterial lipopolysaccharide (LPS) on the expression of the pro-inflammatory cytokines TNFalpha and IL-1beta using the mouse macrophage cell line RAW264.7 as a model.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of pro-inflammatory in macrophage associated with paracetamol, inflammation and cytokine
3) Confidence 0.14 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.37 Pain Relevance 1.00
However, eAE treatment modulated the pro- and anti-inflammatory cytokine levels at a dose of 60?
Regulation (modulated) of Gene_expression (levels) of anti-inflammatory cytokine associated with inflammation and cytokine
4) Confidence 0.05 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2976071 Disease Relevance 0.50 Pain Relevance 0.76
The changes in expression of pro-inflammatory genes 24 h post reperfusion were assessed by quantitative reverse transcription polymerase chain reaction (RT–PCR).
Regulation (changes) of Gene_expression (expression) of pro-inflammatory associated with inflammation
5) Confidence 0.01 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC3013064 Disease Relevance 1.29 Pain Relevance 0.23
However, effects of systemic administration of a TSA on inflammation-related fibrogenic reaction in the ocular surface, and its effects on pro-inflammatory cytokine expression in the macropahges, and on signal transduction in ocular fibroblasts have not yet been investigated.
Regulation (effects) of Gene_expression (expression) of pro-inflammatory in fibroblasts associated with inflammation and cytokine
6) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.88 Pain Relevance 0.30
Among the transcription factors that regulate the expression of pro-inflammatory cytokines and chemokines, a prominent role is played by NF-?
Regulation (regulate) of Gene_expression (expression) of pro-inflammatory associated with chemokine, inflammation and cytokine
7) Confidence 0.00 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.76 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox