INT161508

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.46
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tlr4, Mapk14) mitochondrion (Mapk14) cell morphogenesis (Mapk14)
intracellular (Tlr4) response to stress (Mapk14) cytosol (Mapk14)
Anatomy Link Frequency
microglial cells 1
Tlr4 (Mus musculus)
Mapk14 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 100.00 Very High Very High Very High
cytokine 43 95.96 Very High Very High Very High
Inflammation 88 82.72 Quite High
Inflammatory response 3 72.88 Quite High
cINOD 21 5.00 Very Low Very Low Very Low
agonist 21 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 97 82.72 Quite High
Injury 9 81.84 Quite High
Toxicity 1 74.12 Quite High
Disease 87 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 21 5.00 Very Low Very Low Very Low
Amyloid Plaque 12 5.00 Very Low Very Low Very Low
Aging 9 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 9 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Dementia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, we found that p38MAPK, JNK, and ERK were activated by APAP or LPS alone or in association.
LPS Positive_regulation (activated) of p38MAPK associated with paracetamol
1) Confidence 0.19 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.30 Pain Relevance 1.17
These observations promoted us to investigate the effect of cross-linking CD45RB on LPS-induced p38 MAPK activity in microglial cells.
LPS Positive_regulation (induced) of p38 MAPK in microglial cells
2) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0 Pain Relevance 0
Cross-linking of CD45RB inhibits LPS induced activation of p38 pathway as well as microglial activation
LPS Positive_regulation (activation) of p38
3) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0 Pain Relevance 0
This effect was markedly suppressed by CD45RB antibody (2.5 µg/mL), suggesting that cross-linking CD45RB may attenuate activation of p38 MAPK induced by LPS.
LPS Positive_regulation (induced) of p38 MAPK
4) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.15 Pain Relevance 0.07

General Comments

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