INT161511

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Context Info
Confidence 0.41
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) aging (Il1b) cell morphogenesis (Mapk14)
response to stress (Mapk14) cytoplasm (Mapk14) cytosol (Mapk14)
Mapk14 (Mus musculus)
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 100.00 Very High Very High Very High
cytokine 7 96.00 Very High Very High Very High
Inflammation 4 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 75.00 Quite High
Toxicity 1 64.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When inhibiting MAPKs using pharmacological inhibitors, we showed that p38MAPK inhibition abrogated the synergistic effect of APAP and LPS found for TNFalpha production but not for IL-1beta production.
Negative_regulation (inhibition) of p38MAPK Negative_regulation (abrogated) of Gene_expression (production) of IL-1beta associated with paracetamol
1) Confidence 0.41 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.27 Pain Relevance 1.36

General Comments

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