INT161512

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ppig, S100a8) isomerase activity (Ppig) protein folding (Ppig)
extracellular space (S100a8) extracellular region (S100a8) nucleus (Ppig)
Anatomy Link Frequency
macrophages 2
Ppig (Mus musculus)
S100a8 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 100.00 Very High Very High Very High
cytokine 7 100.00 Very High Very High Very High
Inflammation 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 100.00 Very High Very High Very High
Toxicity 1 45.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This work suggests that in macrophages, APAP and LPS can synergistically provoke the induction of pro-inflammatory cytokines, an effect involving the MAPK pathway and APAP bioactivation by CYP and PGHS.
CYP Negative_regulation (provoke) of Positive_regulation (induction) of pro-inflammatory in macrophages associated with paracetamol, inflammation and cytokine
1) Confidence 0.02 Published 2009 Journal J Immunotoxicol Section Abstract Doc Link 19589095 Disease Relevance 0.23 Pain Relevance 1.12

General Comments

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