INT161515

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Context Info
Confidence 0.64
First Reported 2007
Last Reported 2011
Negated 5
Speculated 2
Reported most in Body
Documents 50
Total Number 53
Disease Relevance 41.52
Pain Relevance 13.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17a) extracellular region (Il17a)
Anatomy Link Frequency
T cells 22
respiratory 6
lungs 4
Th17 cells 4
synovium 4
Il17a (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1143 100.00 Very High Very High Very High
Arthritis 381 100.00 Very High Very High Very High
Inflammation 801 99.84 Very High Very High Very High
cytokine 1351 99.82 Very High Very High Very High
Inflammatory mediators 17 99.16 Very High Very High Very High
addiction 6 97.64 Very High Very High Very High
Multiple sclerosis 414 97.24 Very High Very High Very High
Angina 13 97.16 Very High Very High Very High
chemokine 169 96.64 Very High Very High Very High
Inflammatory response 94 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1144 100.00 Very High Very High Very High
Arthritis 305 100.00 Very High Very High Very High
Urological Neuroanatomy 24 100.00 Very High Very High Very High
Infection 1612 99.98 Very High Very High Very High
INFLAMMATION 869 99.84 Very High Very High Very High
Sprains And Strains 933 99.78 Very High Very High Very High
Burns 126 99.72 Very High Very High Very High
Colitis 62 99.54 Very High Very High Very High
Disease 872 99.52 Very High Very High Very High
Injury 73 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Remarkably, a robust and early induction of IL-17A production by ??
Positive_regulation (induction) of Gene_expression (production) of IL-17A
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.63 Pain Relevance 0.07
Infection with 100×LD50 significantly enhanced IL-17A production as compared to infection with 0.1×LD50, when measured on day 2 (Figure 5, B2-B3).
Positive_regulation (enhanced) of Gene_expression (production) of IL-17A associated with infection
2) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.70 Pain Relevance 0.05
Intranasal LVS infection triggers a robust production of IL-17A by specific pulmonary T cell subpopulations
Positive_regulation (triggers) of Gene_expression (production) of IL-17A in T cell associated with sprains and strains and infection
3) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.08 Pain Relevance 0.19
Of interest, also IL-17A expression was increased in these cocultures with synovial fibroblast indicating the induction of a proinflammatory feedback loop.
Positive_regulation (increased) of Gene_expression (expression) of IL-17A in fibroblast
4) Confidence 0.54 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.62 Pain Relevance 0.35
The contribution of various pulmonary T-cell subpopulations to production of IL-17A
Positive_regulation (subpopulations) of Gene_expression (production) of IL-17A in T-cell
5) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.72 Pain Relevance 0
Results suggest that CD4+ cells are the major contributors to IL-17A production in infected LVS lungs, yet ??
Positive_regulation (contributors) of Gene_expression (production) of IL-17A in lungs associated with sprains and strains
6) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.55 Pain Relevance 0
Intranasal LVS infection triggers a robust production of IL-17A by specific pulmonary T cell subpopulations
Positive_regulation (subpopulations) of Gene_expression (production) of IL-17A in T cell associated with sprains and strains and infection
7) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.09 Pain Relevance 0.19
Intranasal LVS infection triggers a robust production of IL-17A by specific pulmonary T cell subpopulations
Positive_regulation (robust) of Gene_expression (production) of IL-17A in T cell associated with sprains and strains and infection
8) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.08 Pain Relevance 0.19
Production of IL-6 by IL-17-producing CD4 T cells was also examined however most IL-17-producing CD4 T cells failed to produce IL-6 (data not shown).


Positive_regulation (by) of Spec (examined) Gene_expression (Production) of IL-17-producing in T cells
9) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.58 Pain Relevance 0.34
IL-22 production by Th17 cells has been shown to be dependent upon IL-23 [38,45,46], thus our observation, which corroborates that of Shen et al. [25], that very few IL-17-producing CD4 T cells express IL-23R provides a potential explanation for the paucity of IL-22-positive IL-17-positive CD4 T cells we observed.
Positive_regulation (few) of Gene_expression (express) of IL-17-producing in T cells
10) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.64 Pain Relevance 0.32
IL-17 double positive CD4 T cells amongst SFMC (0.83% (0.46 to 2.12)) and PBMC (0.31% (0.14 to 0.82)) or in the median frequency of the IFN?
Positive_regulation (frequency) of Gene_expression (double) of IL-17 in T cells
11) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.51 Pain Relevance 0.31
Analysis of IL-22 and IL-23R expression on IL-17-positive CD4 T cells in PBMC and SFMC of patients with RA
Positive_regulation (on) of Gene_expression (expression) of IL-17-positive in T cells associated with rheumatoid arthritis
12) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.39 Pain Relevance 0.38
Mast cells have recently been identified as a source of IL-17 in RA synovium and are potent producers of IL-17 upon stimulation with TNF?
Positive_regulation (upon) of Gene_expression (producers) of IL-17 in synovium associated with rheumatoid arthritis
13) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.94 Pain Relevance 0.65
Ziolkowska et al. demonstrated that RA PBMC produced significantly more IL-17 than SFMC when challenged with PMA/ionomycin in vitro, however, stimulation with IL-15 induced greater IL-17 production from SFMC than PBMC [21].
Positive_regulation (induced) of Gene_expression (production) of IL-17 associated with rheumatoid arthritis
14) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.65 Pain Relevance 0.49
The results showed that the expression of IL-17 was significantly elevated (P < .01) at 2 weeks PI and turned to normal thereafter (Figure 4).
Positive_regulation (elevated) of Gene_expression (expression) of IL-17
15) Confidence 0.43 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2786920 Disease Relevance 0.24 Pain Relevance 0.17
Following studies were conducted at each time point: histological changes of jejunum were observed; the jejunal smooth muscle contractility was investigated in response to acetylcholine; the levels of IL-17, IL-23, and TGF-?
Spec (investigated) Positive_regulation (investigated) of Spec (investigated) Gene_expression (levels) of IL-17 in smooth muscle
16) Confidence 0.43 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2786920 Disease Relevance 0.22 Pain Relevance 0
and IL-6, the production of IL-17A could not be further induced by infection doses beyond 10×LD50, which could be explained by reaching the maximal production capacity by the host or, alternatively, by a bacterial inhibitory mechanism that hinders the production or affect the sustainability of IL-17A.

??

Neg (not) Positive_regulation (induced) of Gene_expression (production) of IL-17A associated with infection
17) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.82 Pain Relevance 0.07
Noteworthy, the production of IL-17A following sub-lethal airway infection was of transient nature, peaking around days 4-6 and apparently preceding the full-blown disease (days 6–8).
Positive_regulation (following) of Gene_expression (production) of IL-17A associated with disease and infection
18) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.94 Pain Relevance 0.09
and IL-6, the production of IL-17A could not be further induced by infection doses beyond 10×LD50.


Neg (not) Positive_regulation (induced) of Gene_expression (production) of IL-17A associated with infection
19) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.14 Pain Relevance 0.20
The proportion of Th17 cells and the expression of IL-17 were upregulated in jejunum at 2 weeks PI and normalized at 8 weeks PI.
Positive_regulation (upregulated) of Gene_expression (expression) of IL-17 in jejunum
20) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2786920 Disease Relevance 0.45 Pain Relevance 0.12

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