INT161521

Context Info Confidence 0.14 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.41 Pain Relevance 0.42

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1) cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)

Anatomy Link Frequency spinal cord 2 H2-M3 (Mus musculus) Mapk1 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 2 99.68 Morphine 3 75.00 Pain 3 74.72 nMDA receptor 1 64.56 antagonist 2 62.52 nMDA receptor antagonist 1 59.20 substance P 2 57.48 Analgesic 3 43.36 intrathecal 1 39.40 nociceptor 1 25.00

Disease Link Frequency Relevance Heat Nociception 5 99.00 Pain 2 74.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In western blotting analysis, inhibiting M3G-induced nociceptive response using these inhibitors resulted in a significant blockade of ERK activation induced by M3G in the spinal cord.

Negative_regulation (blockade) of M3G Positive_regulation (activation) of ERK in spinal cord associated with nociception and spinal cord

1) Confidence 0.14 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19589334 Disease Relevance 0.41 Pain Relevance 0.42

General Comments

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