INT161524

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.18
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Clu) extracellular space (Clu) cell death (Clu)
extracellular region (Clu) endoplasmic reticulum (Clu) nucleus (Clu)
Anatomy Link Frequency
MCF-7 1
ventral lobe 1
Clu (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 3 62.72 Quite High
cytokine 3 30.72 Quite Low
Dismenorea 2 10.00 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 81 99.00 Very High Very High Very High
Metastasis 8 98.96 Very High Very High Very High
Sprains And Strains 372 98.68 Very High Very High Very High
Apoptosis 25 88.80 High High
Stress 16 75.04 Quite High
Cancer 236 74.48 Quite High
Death 9 63.60 Quite High
Targeted Disruption 6 53.92 Quite High
Reprotox - General 1 7 51.96 Quite High
Pituitary Cancer 3 25.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on these results, we speculate that elevated clusterin levels may contribute to the enhanced rate of prostate tumor development and progression observed in the TRAMP FVB/N genotype.


Spec (may) Regulation (contribute) of clusterin associated with prostate cancer
1) Confidence 0.38 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.98 Pain Relevance 0
Several genes exhibiting strain-dependent differences in prostate expression have been studied in the context of prostate development (for example, Sbp), androgen regulation (Fabp5, Odc), tumorigenesis (for example, Psca, Azgp1, Apod, Mmp7, Egf, Mgst1, Clusterin), and the progression of metastatic cancer (Cxcl12, B2m, H2 family members) [8].
Regulation (regulation) of Clusterin associated with sprains and strains and metastasis
2) Confidence 0.23 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 1.04 Pain Relevance 0.03
However, substantially greater clusterin immunoreactivity was observed in the secretory epithelium of the ventral lobe of the FVB/N strain, relative to any other lobe and all other strains.
Regulation (immunoreactivity) of clusterin in ventral lobe associated with sprains and strains
3) Confidence 0.20 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 0.82 Pain Relevance 0
Our previous studies have suggested that in MCF-7 cells clusterin biogenesis is altered by profound changes in the post-translational modifications that occur after treatment with tamoxifen.
Regulation (altered) of clusterin in MCF-7
4) Confidence 0.16 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.30 Pain Relevance 0
Responsiveness of the UCLA-PCI in the short-term recovery period (12 months post-treatment) was better than in the chronic recovery phase (12-24 months) across almost all domains.
Regulation (Responsiveness) of UCLA-PCI
5) Confidence 0.14 Published 2010 Journal Urology Section Body Doc Link 19589573 Disease Relevance 0.05 Pain Relevance 0

General Comments

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