INT161529

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.70
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Tlr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cancer pain 49 99.48 Very High Very High Very High
cytokine 14 90.88 High High
Inflammation 3 85.20 High High
cINOD 2 71.84 Quite High
Inflammatory response 2 65.44 Quite High
Brush evoked pain 8 42.88 Quite Low
Spontaneous pain 8 26.80 Quite Low
withdrawal 3 23.60 Low Low
intrathecal 13 18.40 Low Low
Pain 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Cancer 54 99.68 Very High Very High Very High
Necrosis 2 99.36 Very High Very High Very High
Cancer 20 99.18 Very High Very High Very High
Injury 13 95.92 Very High Very High Very High
INFLAMMATION 7 85.20 High High
Sprains And Strains 4 76.36 Quite High
Enteropathy 4 72.64 Quite High
Polycystic Ovary Syndrome 7 57.84 Quite High
Neuropathic Pain 20 42.88 Quite Low
Cancer Pain 2 34.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that TLR4 expression was significantly up-regulated in the bone cancer pain model caused by Walker 256 cells inoculation.


Regulation (regulated) of Gene_expression (expression) of TLR4 associated with cancer pain and bone cancer
1) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.85 Pain Relevance 0.51
One-week treatment with viable LcS prevented indomethacin-induced intestinal injury with increase in the concentration of lactic acid in small intestinal content and inhibited increases in myeloperoxidase activity and expression of mRNA for tumor necrosis factor-alpha (TNF-alpha) while affecting neither TLR4 expression nor the number of gram-negative bacteria in intestinal content, whereas neither heat-killed LcS nor a single dose of viable LcS inhibited intestinal injury.
Neg (nor) Regulation (affecting) of Neg (neither) Gene_expression (expression) of TLR4 associated with necrosis, cancer and injury
2) Confidence 0.32 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19589943 Disease Relevance 1.16 Pain Relevance 0.15
Western blot analyses showed that both L-lactic acid and LcS culture supernatants suppressed phosphorylation and degradation of I-kappaB-alpha induced by LPS without affecting expression of TLR4.
Neg (without) Regulation (affecting) of Gene_expression (expression) of TLR4
3) Confidence 0.24 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19589943 Disease Relevance 0.69 Pain Relevance 0.03

General Comments

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