INT16153

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Context Info
Confidence 0.77
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.56
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Cenpj) cytoplasm (Cenpj)
Anatomy Link Frequency
lung 2
ribs 1
upper 1
respiratory 1
Cenpj (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 35 94.52 High High
analgesia 1 89.24 High High
epidural 3 88.84 High High
Regional anesthesia 2 19.52 Low Low
Inflammation 24 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
Dopamine 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sleep Disorders 61 95.52 Very High Very High Very High
Apnoea 66 95.16 Very High Very High Very High
Flail Chest 6 89.20 High High
Atelectasis 19 87.92 High High
Obesity 335 87.44 High High
Contusions 2 86.32 High High
Shock 3 78.20 Quite High
Genetic Predisposition To Disease 2 67.52 Quite High
Obesity-hypoventilation Syndrome 56 61.88 Quite High
Body Weight 12 52.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine upper airway (UA) and ventilatory responses to nasal continuous positive airway pressure (CPAP) and expiratory positive airway pressure (EPAP), we quantitated changes in alae nasi (AN) and genioglossus (GG) electromyographic (EMG) activity, ventilatory timing, and end-expiratory lung volume (EELV) at various levels of CPAP and EPAP in six normal subjects during wakefulness and in seven during sleep.
Gene_expression (levels) of CPAP in lung
1) Confidence 0.77 Published 1996 Journal J. Appl. Physiol. Section Abstract Doc Link 8828699 Disease Relevance 0 Pain Relevance 0.15
Airflow was measured at muLtiple levels of CPAP, and upper airway collapsibility was defined by the pressure below which airflow ceased (the "critical" pressure, Pcrit).
Gene_expression (levels) of CPAP in upper
2) Confidence 0.77 Published 2009 Journal Harefuah Section Abstract Doc Link 19630362 Disease Relevance 0.24 Pain Relevance 0.46
ELectrical stimulation shifted the pressure-flow reLationships toward higher flow Levels in all patients over the entire range of CPAP applied.
Gene_expression (range) of CPAP
3) Confidence 0.66 Published 2009 Journal Harefuah Section Abstract Doc Link 19630362 Disease Relevance 0.22 Pain Relevance 0.59
Oxygen therapy alone was not effective in those with more than 5 fractured ribs, while CPAP was effective in those with up to 10 fractured ribs.
Gene_expression (effective) of CPAP in ribs
4) Confidence 0.59 Published 1991 Journal Harefuah Section Abstract Doc Link 1800278 Disease Relevance 0.64 Pain Relevance 0.13
We therefore conclude that the control of Z0 pressure relationship for the calculation of the maximum is of some importance for determination of therapeutic levels of CPAP.
Gene_expression (levels) of CPAP
5) Confidence 0.59 Published 1984 Journal Anaesthesist Section Abstract Doc Link 6393816 Disease Relevance 0 Pain Relevance 0
In addition, studies have shown that commencing CPAP therapy at least a week before surgery helps improve UA collapsibility, reduce leptin levels, and augment respiratory drive and chemoresponsiveness. 27

Conclusion

Gene_expression (therapy) of CPAP in respiratory
6) Confidence 0.31 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 0.61 Pain Relevance 0.09
In an earlier study by the same authors, higher CPAP pressures were found to be required in order to overcome UA obstruction at reduced lung volumes.34 It appears that lower lung volumes decrease the caudal traction on the UA during lung inflation, producing lesser longitudinal tension on the pharyngeal walls, especially in the supine position.35
Gene_expression (pressures) of CPAP in lung
7) Confidence 0.31 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 0.85 Pain Relevance 0
Difficulties with CPAP use, such as inadequate CPAP pressure and microarousals and sleep disruption caused by wearing the CPAP apparatus, should be addressed (Hirshkowitz and Black 2007).
Gene_expression (pressure) of CPAP
8) Confidence 0.07 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761173 Disease Relevance 0 Pain Relevance 0

General Comments

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