INT161549

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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.08
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TDRD6) endoplasmic reticulum (TDRD6) cytoplasm (TDRD6)
TDRD6 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 4 98.82 Very High Very High Very High
Pain 48 87.32 High High
Action potential 3 84.04 Quite High
Facet joint 4 63.52 Quite High
visual analogue scale 20 5.00 Very Low Very Low Very Low
backache 14 5.00 Very Low Very Low Very Low
Chronic low back pain 4 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arrhythmia Under Development 4 97.04 Very High Very High Very High
Intervertebral Disk Degeneration 8 96.24 Very High Very High Very High
Heart Rate Under Development 1 95.04 Very High Very High Very High
Disease 50 90.64 High High
Pain 54 87.32 High High
Stress 2 84.08 Quite High
Vasculitis 4 74.68 Quite High
Osteoarthritis 4 64.04 Quite High
Osteolysis 4 52.44 Quite High
Pseudarthrosis 2 46.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some studies suggest adjacent level degeneration is prevented after TDR [6, 12].
Negative_regulation (prevented) of TDR
1) Confidence 0.17 Published 2010 Journal Eur Spine J Section Body Doc Link PMC2989191 Disease Relevance 0.46 Pain Relevance 0.03
These cohort studies lacked control group, which is necessary to evaluate effectiveness of TDR.
Negative_regulation (effectiveness) of TDR
2) Confidence 0.17 Published 2010 Journal Eur Spine J Section Body Doc Link PMC2989191 Disease Relevance 0.17 Pain Relevance 0.09
In the presence of 60 nM E-4031, TTX (0.6-3 muM) and ranolazine (5-10 muM) shortened MAPD(90), decreased TDR, BVR, and T(peak)-T(end) (n = 9-20, P < 0.01), and abolished episodes of TdP.
Negative_regulation (decreased) of TDR associated with tetrodotoxin and arrhythmia under development
3) Confidence 0.17 Published 2009 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 19592609 Disease Relevance 0.45 Pain Relevance 0.46

General Comments

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