INT16155

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Context Info
Confidence 0.70
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 6.21
Pain Relevance 17.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npff) extracellular region (Npff)
Anatomy Link Frequency
spinal cord 5
spinal 3
posterior pituitary 2
SH-SY5Y 1
polymodal neuron 1
Npff (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 70 100.00 Very High Very High Very High
Morphine 33 99.98 Very High Very High Very High
antagonist 8 99.96 Very High Very High Very High
Spinal cord 22 99.84 Very High Very High Very High
Central nervous system 8 99.68 Very High Very High Very High
Pain 42 99.50 Very High Very High Very High
Inflammation 14 99.40 Very High Very High Very High
allodynia 2 99.36 Very High Very High Very High
Antinociceptive 8 99.04 Very High Very High Very High
Opioid 33 98.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 34 99.50 Very High Very High Very High
INFLAMMATION 12 99.40 Very High Very High Very High
Neuropathic Pain 9 99.36 Very High Very High Very High
Tics 5 99.28 Very High Very High Very High
Inflammatory Pain 4 98.68 Very High Very High Very High
Cv Unclassified Under Development 2 96.48 Very High Very High Very High
Neuroblastoma 2 95.08 Very High Very High Very High
Nociception 11 91.76 High High
Hyperalgesia 1 89.64 High High
Opiate Addiction 4 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, immunohistochemically, NPFF receptor 2-protein was demonstrated to be increased in the primary afferents in the spinal cord of rats with peripheral inflammation.
Positive_regulation (increased) of NPFF in spinal cord associated with inflammation and spinal cord
1) Confidence 0.70 Published 2006 Journal Peptides Section Abstract Doc Link 16443306 Disease Relevance 0.54 Pain Relevance 0.70
The up-regulation of NPFF may play a homeostatic role in response to specific cardiovascular challenges, such as hypotension.
Positive_regulation (up-regulation) of NPFF associated with cv unclassified under development
2) Confidence 0.69 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11984823 Disease Relevance 0.16 Pain Relevance 0.07
A significant decrease of NPFF-IR was observed 1 h after morphine pellet implantation (-25% to -45% depending on the structures) followed by a drastic increase of NPFF-IR levels (+60 to +140%) between 3 and 6 h.
Positive_regulation (increase) of NPFF-IR associated with morphine
3) Confidence 0.68 Published 1995 Journal Peptides Section Abstract Doc Link 8545244 Disease Relevance 0.39 Pain Relevance 1.84
We found an activation of spinal NPFF and NPFF2 receptor during early inflammatory pain.
Positive_regulation (activation) of NPFF in spinal associated with ipn
4) Confidence 0.67 Published 2004 Journal Neurobiol. Dis. Section Abstract Doc Link 15207282 Disease Relevance 1.04 Pain Relevance 1.48
Pretreatment with 600 ng of NPFF itself, or of NPFF modified at the N-terminal only (daY9Fa), failed to attenuate subsequent naloxone-precipitated abstinence, suggesting that the C-terminal modification is critical for NPFF antagonist activity.
Positive_regulation (critical) of NPFF associated with antagonist and narcan
5) Confidence 0.50 Published 1991 Journal Peptides Section Abstract Doc Link 1800944 Disease Relevance 0.27 Pain Relevance 0.75
Our results confirm the evolutionary conservation of NPFF, NPAF, and NPSF neuropeptide expression in mammalian brain.
Positive_regulation (conservation) of NPFF in brain associated with neuropeptide
6) Confidence 0.49 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220558 Disease Relevance 0.42 Pain Relevance 0.91
The results suggest that the antinociceptive and morphine modulatory effects resulting from activation of spinal NPFF receptors could be due to an increase in the actions or availability of adenosine.
Positive_regulation (activation) of NPFF in spinal associated with adenocard, antinociceptive and morphine
7) Confidence 0.49 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11040346 Disease Relevance 0 Pain Relevance 1.13
These results demonstrate that activation of both NPFF(1) and NPFF(2) receptors has the same cellular anti-opioid effect.
Positive_regulation (activation) of NPFF associated with opioid
8) Confidence 0.49 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12932818 Disease Relevance 0 Pain Relevance 0.46
In contrast, unilateral microinjections of kainic acid into the dorsal horn dramatically reduced [(125)I]1DMe-specific binding in the superficial layers, revealing localization of a population of NPFF receptors on the spinal intrinsic neurons.
Positive_regulation (population) of NPFF in dorsal horn associated with dorsal horn
9) Confidence 0.49 Published 2000 Journal Synapse Section Abstract Doc Link 10579807 Disease Relevance 0.09 Pain Relevance 0.71
Thus, "over-activation" of NPFF receptors by PFR(Tic)amide induced different bio-effects from those induced by NPFF in vivo.
Positive_regulation (activation) of NPFF associated with tics
10) Confidence 0.44 Published 2006 Journal Peptides Section Abstract Doc Link 16490283 Disease Relevance 0.52 Pain Relevance 0.42
First, by using in vitro superfusion system with rat spinal cord slices, we showed that morphine stimulated NPFF release in a dose-dependent manner.
Positive_regulation (stimulated) of NPFF in spinal cord associated with morphine and spinal cord
11) Confidence 0.43 Published 1995 Journal Brain Res. Section Abstract Doc Link 8624708 Disease Relevance 0.16 Pain Relevance 1.00
The spinal NPFF system is up-regulated by peripheral inflammation in the rat.
Positive_regulation (up-regulated) of NPFF in spinal associated with inflammation
12) Confidence 0.41 Published 2006 Journal Peptides Section Abstract Doc Link 16443306 Disease Relevance 0.54 Pain Relevance 0.68
Neuropeptide-FF (NPFF) is unevenly distributed in the central nervous system, with the highest concentrations in posterior pituitary and spinal cord.
Positive_regulation (distributed) of Neuropeptide-FF in spinal cord associated with neuropeptide, central nervous system and spinal cord
13) Confidence 0.40 Published 1993 Journal Endocrinology Section Abstract Doc Link 8404597 Disease Relevance 0 Pain Relevance 0.33
Neuropeptide-FF (NPFF) is unevenly distributed in the central nervous system, with the highest concentrations in posterior pituitary and spinal cord.
Positive_regulation (distributed) of NPFF in spinal cord associated with neuropeptide, central nervous system and spinal cord
14) Confidence 0.40 Published 1993 Journal Endocrinology Section Abstract Doc Link 8404597 Disease Relevance 0 Pain Relevance 0.33
In addition, NPFF-R2 immunoreactivity in the primary afferents was increased by peripheral inflammation.
Positive_regulation (increased) of NPFF associated with inflammation
15) Confidence 0.40 Published 2008 Journal Neuropeptides Section Abstract Doc Link 17854890 Disease Relevance 0.44 Pain Relevance 1.27
Gene for pain modulatory neuropeptide NPFF: induction in spinal cord by noxious stimuli.
Positive_regulation (induction) of NPFF in spinal cord associated with pain, neuropeptide and spinal cord
16) Confidence 0.39 Published 1999 Journal Mol. Pharmacol. Section Title Doc Link 10220558 Disease Relevance 0.30 Pain Relevance 0.81
Treatment with FF1 antagonists reversed established mechanical allodynia, indicating the possibility of increased NPFF tone through FF1 receptors.
Positive_regulation (increased) of NPFF associated with allodynia and antagonist
17) Confidence 0.39 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20354177 Disease Relevance 0.75 Pain Relevance 0.62
In contrast, the constant presence of NPFF(1) receptors in the septum, the nucleus of the tractus solitarius, and the hypothalamus suggest its participation in neuroendocrine functions.
Positive_regulation (presence) of NPFF in nucleus
18) Confidence 0.36 Published 2004 Journal Synapse Section Abstract Doc Link 14696013 Disease Relevance 0 Pain Relevance 0.38
In addition, stimulation of NPFF receptors in living cells modified the G-protein environment of MOP receptor by favoring its interaction with alpha(s), alpha(i2) and beta subunits.
Positive_regulation (stimulation) of NPFF associated with opioid
19) Confidence 0.32 Published 2010 Journal Neurochem. Int. Section Abstract Doc Link 20211672 Disease Relevance 0 Pain Relevance 1.29
Neuropeptide-FF (NPFF) is unevenly distributed in the central nervous system, with the highest concentrations in posterior pituitary and spinal cord.
Positive_regulation (distributed) of Neuropeptide-FF in posterior pituitary associated with neuropeptide, central nervous system and spinal cord
20) Confidence 0.14 Published 1993 Journal Endocrinology Section Abstract Doc Link 8404597 Disease Relevance 0 Pain Relevance 0.33

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