INT16157

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Context Info
Confidence 0.26
First Reported 1985
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 1.14

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enzyme regulator activity (CPN2) extracellular region (CPN2)
Anatomy Link Frequency
cerebrospinal fluid 2
plasma 1
mast cell 1
CPN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 11 100.00 Very High Very High Very High
bradykinin 1 92.96 High High
Dynorphin 1 89.88 High High
substance P 2 73.68 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the enzyme shares some properties with other carboxypeptidase B-like enzymes, it is structurally, catalytically, and immunologically distinct from pancreatic carboxypeptidase A or B, human plasma carboxypeptidase N, and carboxypeptidase H ("enkephalin convertase").
Gene_expression (shares) of carboxypeptidase in plasma associated with enkephalin
1) Confidence 0.26 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2914904 Disease Relevance 0 Pain Relevance 0.47
Purified mast cell carboxypeptidase cleaved the C-terminal leucines from Leu5-enkephalin (Leu-ENK), neurotensin (NT), and kinetensin (KT), with Km values of 36, 16, and 15 microM, and kcat values of 44, 51, and 53 s-1, respectively.
Gene_expression (cleaved) of carboxypeptidase in mast cell associated with enkephalin
2) Confidence 0.14 Published 1991 Journal Peptides Section Abstract Doc Link 1800960 Disease Relevance 0 Pain Relevance 0.24
In human cerebrospinal fluid, aminopeptidase, dipeptidyl aminopeptidase, dipeptidyl carboxypeptidase, and carboxypeptidase which were capable of hydrolyzing enkephalins were detected.
Gene_expression (detected) of carboxypeptidase in cerebrospinal fluid associated with enkephalin
3) Confidence 0.11 Published 1985 Journal Biochem. Int. Section Abstract Doc Link 2409980 Disease Relevance 0 Pain Relevance 0.21
In human cerebrospinal fluid, aminopeptidase, dipeptidyl aminopeptidase, dipeptidyl carboxypeptidase, and carboxypeptidase which were capable of hydrolyzing enkephalins were detected.
Gene_expression (detected) of carboxypeptidase in cerebrospinal fluid associated with enkephalin
4) Confidence 0.11 Published 1985 Journal Biochem. Int. Section Abstract Doc Link 2409980 Disease Relevance 0 Pain Relevance 0.21

General Comments

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