INT161575

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 5.28
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CACNA1A) cell death (CACNA1A) plasma membrane (CACNA1A)
nucleus (CACNA1A) transmembrane transport (CACNA1A) cytoplasm (CACNA1A)
CACNA1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 5 99.88 Very High Very High Very High
Migraine 83 98.48 Very High Very High Very High
Electroencephalography 6 97.68 Very High Very High Very High
headache 12 75.48 Quite High
depression 6 51.20 Quite High
nMDA receptor 3 39.32 Quite Low
Dopamine 14 22.92 Low Low
Peripheral nervous system 1 15.20 Low Low
potassium channel 1 6.84 Low Low
antagonist 3 6.80 Low Low
Disease Link Frequency Relevance Heat
Migraine With Aura 50 98.48 Very High Very High Very High
Ataxia 81 97.36 Very High Very High Very High
Amnesia 2 96.60 Very High Very High Very High
Migraine Disorders 46 95.60 Very High Very High Very High
Headache 16 89.88 High High
Dentatorubro-pallidoluysian Atrophy 1 89.52 High High
Frailty 5 85.64 High High
Spinocerebellar Ataxia Type 2 9 83.16 Quite High
Dysarthria 6 79.76 Quite High
Disease 23 78.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although we did not detect any mutations in CACNA1A gene previously reported in FHM1, our case might share same pathogenesis with FHM1.
Localization (reported) of FHM1
1) Confidence 0.75 Published 2009 Journal Rinsho Shinkeigaku Section Abstract Doc Link 19594104 Disease Relevance 1.31 Pain Relevance 0.64
Although we did not detect any mutations in CACNA1A gene previously reported in FHM1, our case might share same pathogenesis with FHM1.
Localization (reported) of CACNA1A gene
2) Confidence 0.75 Published 2009 Journal Rinsho Shinkeigaku Section Abstract Doc Link 19594104 Disease Relevance 1.38 Pain Relevance 0.65
Previous report about FHM (type 1), is caused by mutations contained within the calcium channel gene CACNA1A (localized at C19p13).
Localization (localized) of CACNA1A associated with calcium channel and migraine
3) Confidence 0.60 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2034370 Disease Relevance 1.13 Pain Relevance 0.94
This is the case for SCA1, SCA2, SCA3, SCA6, SCA7, SCA17, and DRPLA, while a CTG repeats is present in SCA8 [207].
Localization (case) of SCA6
4) Confidence 0.16 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 1.46 Pain Relevance 0.03

General Comments

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