INT161593

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Phospho1) cellular_component (Phospho1) biological_process (Phospho1)
Anatomy Link Frequency
microglia 2
Phospho1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 119 86.72 High High
Spinal cord 4 85.84 High High
Multiple sclerosis 1 70.64 Quite High
Neuropathic pain 1 69.72 Quite High
Glutamate 31 38.56 Quite Low
long-term potentiation 8 5.00 Very Low Very Low Very Low
projection neuron 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 1 75.68 Quite High
Demyelinating Disease 1 70.64 Quite High
Neuropathic Pain 1 69.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functionally, these microglia respond to lipopolysaccharide incubation with increases in both phospho-p38 MAPK and OX42 immunostaining, as well as release of ATP, as compared to un-stimulated microglia.
Positive_regulation (increases) of Gene_expression (immunostaining) of phospho-p38 in microglia
1) Confidence 0.26 Published 2009 Journal J. Neurosci. Methods Section Abstract Doc Link 19596375 Disease Relevance 0.22 Pain Relevance 0.26
Surprisingly, opening the feedback loop increases the concentration of both PKAc (Figure 6A1, orange line) and phosphoThr34 (Figure 6A2, orange line) compared with the control condition (Figure 6A, black lines).
Positive_regulation (increases) of Gene_expression (concentration) of phosphoThr34
2) Confidence 0.01 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.18

General Comments

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