INT161599

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 8.61
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
lamina 2
Saa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 176 100.00 Very High Very High Very High
spinal inflammation 45 99.00 Very High Very High Very High
rheumatoid arthritis 4 98.72 Very High Very High Very High
Crohn's disease 50 94.00 High High
Acupuncture 43 85.64 High High
cytokine 74 83.52 Quite High
ischemia 4 83.44 Quite High
Pain 51 83.40 Quite High
Restless leg syndrome 2 82.24 Quite High
Inflammatory marker 18 78.52 Quite High
Disease Link Frequency Relevance Heat
Disease 138 100.00 Very High Very High Very High
Inflammatory Bowel Disease 40 100.00 Very High Very High Very High
Aneurism 9 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 17 99.76 Very High Very High Very High
Alzheimer's Dementia 20 99.68 Very High Very High Very High
Low Back Pain 49 99.00 Very High Very High Very High
Polymyalgia Rheumatica 4 98.86 Very High Very High Very High
Rheumatoid Arthritis 4 98.72 Very High Very High Very High
INFLAMMATION 196 97.92 Very High Very High Very High
Death 6 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most (62%) of the patients underwent SAA ligation and splenectomy.
SAA Binding (ligation) of associated with aneurism
1) Confidence 0.41 Published 2009 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 19596508 Disease Relevance 1.26 Pain Relevance 0.08
, and its level is more sensitive than CRP.6,21-23 Other reports on PMR suggested that serum SAA is more predominant than ESR or CRP with regard to sensitivity and specificity, respectively, and its level can reflect the disease activity effectively.8,24,25 But, in AS, SAA has not been studied as extensively as in RA or PMR, and we could find only a few studies investigating the association between SAA and disease activity of AS.21,26,27 One of these studies reported that SAA levels in patients with AS correlated well with BASDAI scores, and that ESR and CRP levels seem to be a good indicator of disease activity.21 Our results were also similar to those previously reported, but we tried to identify the superiority of SAA to ESR or CRP in determining the extent of AS disease activity.
SAA Binding (association) of associated with spinal inflammation, polymyalgia rheumatica, rheumatoid arthritis and disease
2) Confidence 0.24 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.57 Pain Relevance 0.76
Based on previous research showing that supplementation with sulfur amino acids (SAA) increases plasma Cys and shifts the Eh to a more reduced potential [18], we applied this approach to a mouse model of inflammation in which LPS/endotoxin is administered to increase IL-1?
SAA Binding (supplementation) of in plasma associated with inflammation
3) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2657829 Disease Relevance 0.19 Pain Relevance 0.09
Dietary SAA supplementation protects against endotoxin-induced perturbations in plasma Cys, CySS and Eh Cys/CySS
SAA Binding (supplementation) of in plasma
4) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2657829 Disease Relevance 0.17 Pain Relevance 0.09
chemoattractant; DCs, dendritic cells; IBD, inflammatory bowel disease; JD, Johne's disease; LP, lamina propria; MLN, mesenteric lymph nodes; pDCs, plasmacytoid dendritic cells; PP, Peyer's patches; SAA, serum amyloid A; TLR, toll-like receptor; UC, ulcerative colitis.


SAA Binding (chemoattractant) of in lamina associated with inflammatory bowel disease, inflammation, alzheimer's dementia and disease
5) Confidence 0.16 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.36 Pain Relevance 0.18
chemoattractant; DCs, dendritic cells; IBD, inflammatory bowel disease; JD, Johne's disease; LP, lamina propria; MLN, mesenteric lymph nodes; pDCs, plasmacytoid dendritic cells; PP, Peyer's patches; SAA, serum amyloid A; TLR, toll-like receptor; UC, ulcerative colitis.


SAA Binding (dendritic cells) of in lamina associated with inflammatory bowel disease, inflammation, alzheimer's dementia and disease
6) Confidence 0.16 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.35 Pain Relevance 0.17
CONCLUSION: ESR, CRP, and SAA were significantly associated with the BASDAI over 3 months, and the association with ESR was the strongest.
SAA Binding (associated) of
7) Confidence 0.12 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19877087 Disease Relevance 0.05 Pain Relevance 0
Standardized betas were 0.49 for ESR, 0.43 for CRP, and 0.39 for SAA.
SAA Binding (0.39) of
8) Confidence 0.09 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19877087 Disease Relevance 0.24 Pain Relevance 0
Therefore, larger more diverse studies assessing changes in HDL-cholesterol and its relationship with CRP and SAA following exercise training are warranted.
SAA Binding (relationship) of associated with disorder of lipid metabolism
9) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3022197 Disease Relevance 1.04 Pain Relevance 0.26
Although the physiological significance of SAA remains controversial, some studies have demonstrated that SAA associates with HDL-cholesterol to remove it from the site of inflammation [31].
SAA Binding (associates) of associated with inflammation and disorder of lipid metabolism
10) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3022197 Disease Relevance 0.73 Pain Relevance 0.11
VRS and STAI-I before, immediately following, and 1 day after receiving the treatment, MH and sAA before and immediately after the treatment, NDI before and 1 day after the treatment, satisfaction immediately following and 1 day after the treatment were sampled.
sAA Binding (receiving) of
11) Confidence 0.04 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952311 Disease Relevance 0.58 Pain Relevance 0.57
CRP, sICAM-1, and SAA showed no significant association with air pollutants (data not shown).


SAA Neg (no) Binding (association) of
12) Confidence 0.03 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2762952 Disease Relevance 0.08 Pain Relevance 0.04

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