INT1616

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Context Info
Confidence 0.61
First Reported 1979
Last Reported 2010
Negated 11
Speculated 3
Reported most in Abstract
Documents 46
Total Number 49
Disease Relevance 10.20
Pain Relevance 28.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
striatum 9
neurons 5
dorsal 2
globus pallidus 2
dorsal horn 2
Gad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 209 100.00 Very High Very High Very High
Glutamate 133 100.00 Very High Very High Very High
Enkephalin 124 100.00 Very High Very High Very High
Dynorphin 72 100.00 Very High Very High Very High
substance P 68 100.00 Very High Very High Very High
dopamine receptor 54 100.00 Very High Very High Very High
agonist 48 100.00 Very High Very High Very High
antagonist 33 100.00 Very High Very High Very High
cocaine 30 100.00 Very High Very High Very High
qutenza 18 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 2 100.00 Very High Very High Very High
Generalized Anxiety Disorder 98 99.92 Very High Very High Very High
Bordatella Infection 6 99.80 Very High Very High Very High
Stress 4 98.52 Very High Very High Very High
Parkinson's Disease 87 97.04 Very High Very High Very High
Injury 73 97.00 Very High Very High Very High
Chorea 5 96.96 Very High Very High Very High
Cv Unclassified Under Development 288 96.20 Very High Very High Very High
Disease 95 95.92 Very High Very High Very High
Convulsion 8 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The dizocilpine maleate treatment alone did not induce significant change of GAD67 mRNA levels in the striatum, indicating that NMDA receptors may not have a major role in the transcriptional regulation of GAD67 in the adult rat striatum.
Regulation (regulation) of GAD67 in striatum associated with nmda receptor
1) Confidence 0.61 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9037536 Disease Relevance 0 Pain Relevance 0.45
The dizocilpine maleate treatment alone did not induce significant change of GAD67 mRNA levels in the striatum, indicating that NMDA receptors may not have a major role in the transcriptional regulation of GAD67 in the adult rat striatum.
Regulation (change) of GAD67 in striatum associated with nmda receptor
2) Confidence 0.61 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9037536 Disease Relevance 0 Pain Relevance 0.42
Drug challenge did not further affect GAD67 mRNA in the CeA of saline, drug and stress pre-exposed rats.
Neg (not) Regulation (affect) of GAD67 in CeA associated with stress and amygdala
3) Confidence 0.61 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18312583 Disease Relevance 0.47 Pain Relevance 0.68
Altogether, these results show that GAD67 and preproenkephalin mRNA levels are modulated in parallel in adult but not in 15 day-old rats after 6-hydroxydopamine injections or dopaminergic blockade.
Neg (not) Regulation (modulated) of GAD67
4) Confidence 0.61 Published 1994 Journal Brain Res. Section Abstract Doc Link 8004444 Disease Relevance 0.16 Pain Relevance 0.33
The stimulation did not affect neuropeptide or GAD67 mRNA levels in the side contralateral to the dopamine lesion or in intact animals.
Neg (not) Regulation (affect) of GAD67 associated with dopamine and neuropeptide
5) Confidence 0.60 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12077209 Disease Relevance 0.06 Pain Relevance 0.51
Differential regulation of GAD67, enkephalin and dynorphin mRNAs by chronic-intermittent L-dopa and A2A receptor blockade plus L-dopa in dopamine-denervated rats.
Regulation (regulation) of GAD67 associated with dopamine, dynorphin and enkephalin
6) Confidence 0.60 Published 2002 Journal Synapse Section Title Doc Link 11954048 Disease Relevance 0.09 Pain Relevance 0.72
Chronic administration of the D1 dopamine receptor antagonist SCH-23390 had no significant effect on GAD67, GAD65 or preproenkephalin mRNA levels.
Neg (no) Regulation (effect) of GAD67 associated with antagonist and dopamine receptor
7) Confidence 0.59 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750862 Disease Relevance 0 Pain Relevance 0.63
Alterations in GAD67, dynorphin and enkephalin mRNA in striatal output neurons following priming in the 6-OHDA model of Parkinson's disease.
Regulation (Alterations) of GAD67 in output neurons associated with dynorphin, enkephalin and disease
8) Confidence 0.53 Published 2001 Journal Neurol. Sci. Section Title Doc Link 11487201 Disease Relevance 0.19 Pain Relevance 0.53
The addition of procaine, lidocaine, cocaine, or tetracaine did not alter either glutamic acid decarboxylase (GAD) activity or GABA transaminase (GABA-T) activity in vitro.
Neg (not) Regulation (alter) of glutamic acid decarboxylase associated with gaba, generalized anxiety disorder, lidocaine and cocaine
9) Confidence 0.47 Published 1983 Journal Anesthesiology Section Abstract Doc Link 6859579 Disease Relevance 0.24 Pain Relevance 0.85
Priming differentially affected peptides and GAD67 mRNA in striatopallidal and striatonigral neurons depending on the dopamine agonist used.
Regulation (affected) of GAD67 in neurons associated with dopamine and agonist
10) Confidence 0.45 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622157 Disease Relevance 0 Pain Relevance 1.11
Behavioral studies were correlated to changes in dynorphin and enkephalin mRNAs in the striatum and in glutamic acid decarboxylase 67 (GAD67) mRNA in the striatum, globus pallidus, and substantia nigra.
Regulation (changes) of GAD67 in globus pallidus associated with dynorphin, substantia nigra and enkephalin
11) Confidence 0.45 Published 2003 Journal Neurology Section Abstract Doc Link 14663008 Disease Relevance 0.08 Pain Relevance 0.52
Behavioral studies were correlated to changes in dynorphin and enkephalin mRNAs in the striatum and in glutamic acid decarboxylase 67 (GAD67) mRNA in the striatum, globus pallidus, and substantia nigra.
Regulation (changes) of glutamic acid decarboxylase 67 in globus pallidus associated with dynorphin, substantia nigra and enkephalin
12) Confidence 0.45 Published 2003 Journal Neurology Section Abstract Doc Link 14663008 Disease Relevance 0.08 Pain Relevance 0.52
The D2 dopamine receptor antagonist, sulpiride, did not change the mRNA levels of either GAD67 or PPE in the striatum.
Neg (not) Regulation (change) of GAD67 in striatum associated with antagonist and dopamine receptor
13) Confidence 0.45 Published 1994 Journal Brain Res. Section Abstract Doc Link 8004444 Disease Relevance 0.07 Pain Relevance 0.39
The aim of this study was to further establish, in vivo, evidence for a link between the maturation of spinal cord innervation and the regulation of several isoforms of the synthetic enzymes of GABA, the glutamic acid decarboxylases GAD65, GAD67, and EP10, the embryonic truncated form of GAD67.
Regulation (regulation) of GAD67 in spinal cord associated with gaba and spinal cord
14) Confidence 0.44 Published 1998 Journal Perspect Dev Neurobiol Section Abstract Doc Link 9777631 Disease Relevance 0.16 Pain Relevance 0.58
As compared to the cholinergic marker (choline acetyltransferase activity), glutamic acid decarboxylase activity was significantly more affected by various agents known to inhibit neuronal activity, including tetrodotoxin (1 micron), flunarizine (5 microns), MK 801 (50 microns) and propofol (40 microns).
Regulation (affected) of glutamic acid decarboxylase in neuronal associated with tetrodotoxin
15) Confidence 0.44 Published 1998 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9541740 Disease Relevance 0.37 Pain Relevance 0.38
The present results provide further evidence that GAD67 and GAD65 gene expression is differentially regulated in the two subpopulations of efferent striatal neurons.
Regulation (regulated) of GAD67 in neurons
16) Confidence 0.43 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.37
The effect of intrathecal administration of capsaicin in the rat on thermal nociceptive thresholds and on the content of substance P, somatostatin and glutamic acid decarboxylase in the dorsal horn of the spinal cord was determined.
Spec (determined) Regulation (effect) of glutamic acid decarboxylase in dorsal horn associated with nociception, qutenza, dorsal horn, somatostatin, spinal cord, substance p and intrathecal
17) Confidence 0.43 Published 1981 Journal Brain Res. Section Abstract Doc Link 6165438 Disease Relevance 0.10 Pain Relevance 0.72
The effects of in vivo administration of dopamine receptor agonists or antagonists on the mRNA levels encoding for the two isoforms of glutamate decarboxylase, GAD65 and GAD67, and for preproenkephalin were studied in regions of the rat dorsal striatum by radioactive in situ hybridization histochemistry.
Regulation (effects) of GAD67 in dorsal associated with glutamate, antagonist, dopamine receptor and agonist
18) Confidence 0.43 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750862 Disease Relevance 0 Pain Relevance 0.43
Apomorphine or SKF-38393 treatment did not induce significant effects on GAD67 and preproenkephalin mRNA levels in striatum.
Neg (not) Regulation (effects) of GAD67 in striatum
19) Confidence 0.43 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750862 Disease Relevance 0 Pain Relevance 0.62
Slides from sham rats were processed in parallel with sections from postischemic rats as the positive control for the GAD67 and VGAT immunostaining.
Regulation (control) of GAD67
20) Confidence 0.42 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.22 Pain Relevance 0.09

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