INT161613

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.36
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAD) cytosol (BAD) mitochondrion (BAD)
cytoplasm (BAD)
Anatomy Link Frequency
cleavage 2
BAD (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 3 97.00 Very High Very High Very High
cerebral cortex 1 75.00 Quite High
chemokine 1 8.80 Low Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 10 98.06 Very High Very High Very High
Targeted Disruption 2 97.40 Very High Very High Very High
Apoptosis 60 96.16 Very High Very High Very High
Acute Promyelocytic Leukemia 1 87.00 High High
Cancer 62 85.08 High High
Pancreatic Cancer 72 84.20 Quite High
Death 15 83.20 Quite High
Reprotox - General 1 1 70.44 Quite High
Lymphatic System Cancer 6 66.48 Quite High
Disease 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared with parental cells and vector cells, clone 2 and pool 1 cells transfected with pcDNA3.1-FRNK showed a decrease in survivin expression and Bad phosphorylation at Ser136 but did not affect Bax, Bcl-2 or Bad expression or Bad phosphorylation at Ser112 (Fig. 5E).
Neg (not) Regulation (affect) of Phosphorylation (phosphorylation) of Bad
1) Confidence 0.11 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.63 Pain Relevance 0
Additionally, it has been shown that HDACis have an effect on the cleavage of Bid and phosphorylation of Bad and Bim [31–33].
Regulation (effect) of Phosphorylation (phosphorylation) of Bad in cleavage
2) Confidence 0.08 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 1.09 Pain Relevance 0
Results showed that clonidine administration prior to hypoxia prevents the hypoxia-induced increased nuclear Ca(2+)-influx and increased phosphorylation of Bcl-2 and Bcl-xl while phosphorylation of Bad and Bax was not altered.
Neg (not) Regulation (altered) of Phosphorylation (phosphorylation) of Bad associated with hypoxia and clonidine
3) Confidence 0.03 Published 2010 Journal Neurochem. Res. Section Abstract Doc Link 19597709 Disease Relevance 0.64 Pain Relevance 0.13

General Comments

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