INT161667

Context Info Confidence 0.42 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 2.73 Pain Relevance 1.59

signal transduction (Prokr1) plasma membrane (Prokr1) signal transducer activity (Prokr1)

Anatomy Link Frequency capsule 1 paw 1 peritoneal macrophages 1 Prokr1 (Mus musculus)

Pain Link Frequency Relevance Heat Pain 14 99.84 Inflammation 54 99.70 primary afferent fibers 1 98.16 qutenza 32 97.90 Hyperalgesia 6 96.78 depression 1 96.76 Adelta 1 88.08 dorsal root ganglion 26 87.48 cytokine 127 80.88 Inflammatory response 11 67.40

Disease Link Frequency Relevance Heat Pain 13 99.84 INFLAMMATION 62 99.70 Hypersensitivity 8 99.30 Cryptococcus Infection 1 99.16 Hyperalgesia 11 96.78 Depression 1 96.76 Apoptosis 1 96.16 Infection 15 91.20 Ganglion Cysts 26 87.48 Nociception 33 83.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Whether PK1 or PK2 is responsible for the activation of PKR1 in pain sensitization is unknown.

Positive_regulation (activation) of PKR1 associated with pain

1) Confidence 0.42 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 0.88 Pain Relevance 0.67

Mice lacking PKR genes exhibit impaired Bv8-induced hyperalgesia, develop deficient responses to noxious heat, capsaicin, and protons and show reduced thermal and mechanical hypersensitivity to paw inflammation, indicating a requirement for PKR signaling in activation and sensitization of primary afferent fibers.

Positive_regulation (requirement) of PKR in paw associated with hyperalgesia, inflammation, qutenza, primary afferent fibers and hypersensitivity

2) Confidence 0.38 Published 2009 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 19607967 Disease Relevance 1.00 Pain Relevance 0.51

Measurement of PROKR 1 and PROKR 2 mRNA expression

Positive_regulation (Measurement) of PROKR

3) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.10

This last observation is consistent with our previous results in peritoneal macrophages [19], although does not completely agree with other data showing a relative prevalence of PROKR 2 [18].

Positive_regulation (prevalence) of PROKR in peritoneal macrophages

4) Confidence 0.26 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.03

HT generated the PROKR 1 KO animals

Positive_regulation (generated) of PROKR 1 KO

5) Confidence 0.24 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.29 Pain Relevance 0.23

Hypervirulence has been also observed in other fungal species such as Cryptococcus neoformans where perturbation in cAMP signalling by inactivation of PKR1 (encoding the PKA regulatory subunit) resulted in capsule overproduction [40].

Positive_regulation (inactivation) of PKR1 in capsule associated with cryptococcus infection

6) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.32 Pain Relevance 0

In differentiated mammalian cells, long dsRNA activates RNA-dependent protein kinase PKR and type I interferon response, which leads to a nonspecific global translation depression and apoptosis [6].

Positive_regulation (activates) of kinase PKR associated with depression and apoptosis

7) Confidence 0.01 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.24 Pain Relevance 0.05

General Comments

This test has worked.