INT161667

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.73
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Prokr1) plasma membrane (Prokr1) signal transducer activity (Prokr1)
Anatomy Link Frequency
capsule 1
paw 1
peritoneal macrophages 1
Prokr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 14 99.84 Very High Very High Very High
Inflammation 54 99.70 Very High Very High Very High
primary afferent fibers 1 98.16 Very High Very High Very High
qutenza 32 97.90 Very High Very High Very High
Hyperalgesia 6 96.78 Very High Very High Very High
depression 1 96.76 Very High Very High Very High
Adelta 1 88.08 High High
dorsal root ganglion 26 87.48 High High
cytokine 127 80.88 Quite High
Inflammatory response 11 67.40 Quite High
Disease Link Frequency Relevance Heat
Pain 13 99.84 Very High Very High Very High
INFLAMMATION 62 99.70 Very High Very High Very High
Hypersensitivity 8 99.30 Very High Very High Very High
Cryptococcus Infection 1 99.16 Very High Very High Very High
Hyperalgesia 11 96.78 Very High Very High Very High
Depression 1 96.76 Very High Very High Very High
Apoptosis 1 96.16 Very High Very High Very High
Infection 15 91.20 High High
Ganglion Cysts 26 87.48 High High
Nociception 33 83.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whether PK1 or PK2 is responsible for the activation of PKR1 in pain sensitization is unknown.
Positive_regulation (activation) of PKR1 associated with pain
1) Confidence 0.42 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 0.88 Pain Relevance 0.67
Mice lacking PKR genes exhibit impaired Bv8-induced hyperalgesia, develop deficient responses to noxious heat, capsaicin, and protons and show reduced thermal and mechanical hypersensitivity to paw inflammation, indicating a requirement for PKR signaling in activation and sensitization of primary afferent fibers.
Positive_regulation (requirement) of PKR in paw associated with hyperalgesia, inflammation, qutenza, primary afferent fibers and hypersensitivity
2) Confidence 0.38 Published 2009 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 19607967 Disease Relevance 1.00 Pain Relevance 0.51
Measurement of PROKR 1 and PROKR 2 mRNA expression
Positive_regulation (Measurement) of PROKR
3) Confidence 0.30 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.10
This last observation is consistent with our previous results in peritoneal macrophages [19], although does not completely agree with other data showing a relative prevalence of PROKR 2 [18].
Positive_regulation (prevalence) of PROKR in peritoneal macrophages
4) Confidence 0.26 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.03
HT generated the PROKR 1 KO animals
Positive_regulation (generated) of PROKR 1 KO
5) Confidence 0.24 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.29 Pain Relevance 0.23
Hypervirulence has been also observed in other fungal species such as Cryptococcus neoformans where perturbation in cAMP signalling by inactivation of PKR1 (encoding the PKA regulatory subunit) resulted in capsule overproduction [40].
Positive_regulation (inactivation) of PKR1 in capsule associated with cryptococcus infection
6) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2607542 Disease Relevance 0.32 Pain Relevance 0
In differentiated mammalian cells, long dsRNA activates RNA-dependent protein kinase PKR and type I interferon response, which leads to a nonspecific global translation depression and apoptosis [6].
Positive_regulation (activates) of kinase PKR associated with depression and apoptosis
7) Confidence 0.01 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.24 Pain Relevance 0.05

General Comments

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