INT161682

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.55
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cdc42) plasma membrane (Cdc42) cytoskeleton (Cdc42)
intracellular (Cdc42) GTPase activity (Cdc42) cytoplasm (Cdc42)
Anatomy Link Frequency
extracellular matrix 1
lung 1
T cell 1
vascular endothelium 1
Cdc42 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 48 96.80 Very High Very High Very High
chemokine 18 96.20 Very High Very High Very High
Inflammation 156 95.52 Very High Very High Very High
IPN 1 76.08 Quite High
mu opioid receptor 5 75.00 Quite High
analgesia 1 75.00 Quite High
Analgesic 6 73.60 Quite High
cytokine 66 68.68 Quite High
Pain 7 54.16 Quite High
gABA 1 41.40 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 46 99.56 Very High Very High Very High
Injury 122 99.32 Very High Very High Very High
Multiple Sclerosis 57 96.80 Very High Very High Very High
Lung Injury 80 96.74 Very High Very High Very High
Apoptosis 62 96.64 Very High Very High Very High
Pneumonia 18 95.92 Very High Very High Very High
INFLAMMATION 148 95.10 Very High Very High Very High
Death 29 95.04 Very High Very High Very High
Wound Healing 13 94.80 High High
Stress 22 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular we demonstrated that transient gene transfer of HOXA3 to skin wounds of diabetic mice resulted in the upregulation of target genes, such as Plaur, Mmp14, and Cdc42, that are involved in extracellular matrix remodeling and cell migration.
Positive_regulation (upregulation) of Cdc42 in extracellular matrix associated with diabetes mellitus and injury
1) Confidence 0.53 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.80 Pain Relevance 0.03
Cytotoxic Necrotizing Factor 1 (CNF1) is a protein toxin from Escherichia coli that constitutively activates the Rho, Rac and Cdc42 GTPases.
Positive_regulation (activates) of Cdc42
2) Confidence 0.49 Published 2009 Journal Pain Section Abstract Doc Link 19608345 Disease Relevance 0.13 Pain Relevance 0.38
For example, it has been recently shown that RhoGDIs are required for the efficient transforming activity of the GTPase Cdc42, an observation that suggest that these GTPase inhibitors may also play positive roles in the translocation and/or effector phase of these GTPases [11].
Positive_regulation (required) of Cdc42
3) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.20 Pain Relevance 0
RhoA, Cdc42 and Rac1 can be activated when GTP-bound, and inactivated, when GDP-bound.
Positive_regulation (activated) of Cdc42
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.82 Pain Relevance 0
The top 30 differentially expressed genes in the non-T cell fraction included upregulation of cell division cycle 42 (CDC42), receptor-interacting serine/threonine kinase 2 (RIPK2), IL-1 receptor, type II (IL1R2), the chemokine MIP-2?
Positive_regulation (upregulation) of CDC42 in T cell associated with chemokine
5) Confidence 0.19 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.70 Pain Relevance 0.29
Vania Braga, Imperial College, London, UK), was used to pull down active Rac1 and Cdc42 from MLEC cell lysates transfected with scrambled or Rac1 siRNA.
Positive_regulation (active) of Cdc42
6) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
VSMCs were transfected with dominant negative (DN) expression vectors of the main geranylated proteins Rac-1, Cdc-42 and RhoA.
Positive_regulation (geranylated) of Cdc-42
7) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.80 Pain Relevance 0
In contrast, sn-2-oxygenated, but not sn-2-fragmented, phospholipids (PEIPC and PECPC) are responsible for the OxPAPC-mediated Rac/Cdc42 activation, cytoskeletal remodeling, and induction of barrier-protective effects in the vascular endothelium [21].
Positive_regulation (mediated) of Cdc42 in vascular endothelium
8) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2374596 Disease Relevance 0.48 Pain Relevance 0.03
Besides blunting the Toll-like receptor-4-induced inflammatory cascade and lung dysfunction in a model of lipopolysaccharide-induced lung injury, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) exerts direct barrier-protective effects on pulmonary endothelial cells in vitro via activation of the small GTPases Rac and Cdc42.
Positive_regulation (activation) of Cdc42 in lung associated with lung injury and inflammation
9) Confidence 0.05 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2374596 Disease Relevance 0.62 Pain Relevance 0.18

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