INT1617

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2004
Negated 2
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 0.63
Pain Relevance 9.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 4
spinal 2
nerve 2
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 30 100.00 Very High Very High Very High
opiate 24 100.00 Very High Very High Very High
electroacupuncture 11 100.00 Very High Very High Very High
Kappa opioid receptor 8 100.00 Very High Very High Very High
withdrawal 4 100.00 Very High Very High Very High
Analgesic 3 100.00 Very High Very High Very High
opioid receptor 2 99.96 Very High Very High Very High
cocaine 6 99.80 Very High Very High Very High
Potency 3 99.80 Very High Very High Very High
orphanin 6 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Opiate Addiction 3 100.00 Very High Very High Very High
Glioma 2 80.32 Quite High
Neuroblastoma 2 79.88 Quite High
Pain 1 78.72 Quite High
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Alcohol Addiction 1 5.00 Very Low Very Low Very Low
Nervous System Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic morphine increases mu-opiate receptor binding in rat brain: a quantitative autoradiographic study.
Positive_regulation (increases) of mu-opiate receptor Binding (binding) of in brain associated with opiate and morphine
1) Confidence 0.59 Published 1989 Journal Brain Res. Section Title Doc Link 2539233 Disease Relevance 0 Pain Relevance 0.77
In conclusion, while the steady-state spinal dynorphin release is low in morphine-dependent rats, it can be activated by 100-Hz EA stimulation, which may be responsible for eliciting an analgesic effect and ameliorating morphine withdrawal syndrome, most probably via interacting with kappa-opioid receptor at spinal level.
Positive_regulation (activated) of kappa-opioid receptor Binding (interacting) of in spinal associated with dynorphin, analgesic, kappa opioid receptor, withdrawal, electroacupuncture and morphine
2) Confidence 0.50 Published 1999 Journal Brain Res. Section Abstract Doc Link 10642860 Disease Relevance 0.24 Pain Relevance 2.00
Two possible explanations for the extensive sequence homology between the three major cross-linking products are: (1) the 110 kDa species is the opiate receptor, and the 58 and 29 kDa species are proteolytic fragments; and (2) one of the lower molecular weight species is the opiate receptor, and adjacent receptors are aggregated into the 110 kDa complex through cross-linking.
Spec (possible) Positive_regulation (explanations) of opiate receptor Binding (fragments) of associated with opiate
3) Confidence 0.49 Published 1988 Journal Brain Res. Section Abstract Doc Link 2848613 Disease Relevance 0 Pain Relevance 0.68
Examination of molecular models seemed to indicate that optimal opiate receptor interaction of fentanyl and its derivatives requires a virtually perpendicular position of the anilino phenyl with respect to the amide function.
Positive_regulation (requires) of opiate receptor Binding (interaction) of associated with opiate
4) Confidence 0.47 Published 1981 Journal J. Med. Chem. Section Abstract Doc Link 6268786 Disease Relevance 0 Pain Relevance 0.38
Gestational cocaine exposure increases opiate receptor binding in weanling offspring.
Positive_regulation (increases) of opiate receptor Binding (binding) of associated with narcan, opiate and cocaine
5) Confidence 0.44 Published 1991 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 1655306 Disease Relevance 0 Pain Relevance 0.89
Glutamic acid decarboxylase and choline acetyltransferase activity were unchanged; however, a small decrease in opiate receptor binding occurred 1 month after nerve section.
Positive_regulation (occurred) of opiate receptor Binding (binding) of in nerve associated with opiate
6) Confidence 0.18 Published 1979 Journal Brain Res. Section Abstract Doc Link 221070 Disease Relevance 0 Pain Relevance 1.10
These derivatives and dynorphin A-(1-13)NH2 were evaluated for kappa-opioid receptor binding affinity and potency as inhibitors of adenylyl cyclase.
Positive_regulation (evaluated) of kappa-opioid receptor Binding (affinity) of associated with dynorphin, kappa opioid receptor and potency
7) Confidence 0.17 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9456002 Disease Relevance 0 Pain Relevance 0.61
ICa inhibition by nociceptin was primarily mediated through binding to its own receptor, ORL-1, but not through affecting other mu-opioid receptors.
Positive_regulation (mediated) of ORL-1 Binding (binding) of associated with orphanin and mu opioid receptor
8) Confidence 0.16 Published 2004 Journal Neuroreport Section Abstract Doc Link 15371734 Disease Relevance 0.08 Pain Relevance 0.63
Furthermore, the loss of opiate receptor binding in irradiated cell samples could not be attributed to reduced receptor affinity since increasing concentrations of radiolabeled ligand failed to reverse the inhibition; nonspecific binding decreased only slightly under identical experimental conditions.
Neg (not) Positive_regulation (attributed) of opiate receptor Binding (binding) of associated with opiate
9) Confidence 0.14 Published 1983 Journal J. Biol. Chem. Section Abstract Doc Link 6296128 Disease Relevance 0.31 Pain Relevance 0.66
Suppression of alcohol intake by chronic naloxone treatment in P rats: tolerance development and elevation of opiate receptor binding.
Positive_regulation (elevation) of opiate receptor Binding (binding) of associated with tolerance, narcan, opiate and alcohol
10) Confidence 0.12 Published 1999 Journal Alcohol. Clin. Exp. Res. Section Title Doc Link 10591592 Disease Relevance 0 Pain Relevance 0.35
The infusion of LY274614 for 7 days did not increase the affinity or density of mu, delta, kappa-1 or kappa-3 opioid receptors in rat brain homogenates as measured by ligand binding assays.
Neg (not) Positive_regulation (increase) of kappa-3 Neg (not) Binding (affinity) of in brain associated with opioid receptor
11) Confidence 0.07 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8301558 Disease Relevance 0 Pain Relevance 1.73

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