INT161702

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.19
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GJB2) plasma membrane (GJB2) cell-cell signaling (GJB2)
Anatomy Link Frequency
nail 1
placenta 1
GJB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 97.92 Very High Very High Very High
alcohol 1 86.80 High High
imagery 4 27.68 Quite Low
peripheral neuropathy 1 20.52 Low Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cocaine 1 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
Opioid receptor 1 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 90 99.28 Very High Very High Very High
Pachyonychia Congenita 4 96.40 Very High Very High Very High
Injury 1 89.28 High High
Deafness 80 87.68 High High
Nicotine Addiction 1 86.32 High High
Infection 1 85.96 High High
Congenital Anomalies 2 85.52 High High
Vohwinkel Syndrome 6 83.76 Quite High
Spontaneous Abortion 4 83.52 Quite High
Chromosome Aberrations 1 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some families presenting with FPPK alone, or with minimal nail changes, carry mutations in KRT16; however, most FPPK families do not harbor mutations in any of these keratin genes.
Gene_expression (presenting) of FPPK in nail
1) Confidence 0.65 Published 2010 Journal J. Invest. Dermatol. Section Abstract Doc Link 19609311 Disease Relevance 0.73 Pain Relevance 0.10
In addition, some loci might contain more than one disease gene, as in the case of DFNA3 that harbors GJB2 and GJB6.
Gene_expression (harbors) of GJB2 associated with disease
2) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2946934 Disease Relevance 0.79 Pain Relevance 0
Furthermore connexin26 and connexin43 are expressed in the placenta, and may compensate for the possible loss of connexin32 function [32].
Gene_expression (expressed) of connexin26 in placenta
3) Confidence 0.01 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1999495 Disease Relevance 0.67 Pain Relevance 0.04

General Comments

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