INT161706

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.69
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (S100B) extracellular region (S100B) nucleus (S100B)
cytoplasm (S100B)
S100B (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 6 99.44 Very High Very High Very High
Glutamate 5 97.12 Very High Very High Very High
antagonist 4 94.64 High High
Neuropathic pain 1 93.40 High High
cytokine 10 87.20 High High
Inflammation 11 75.00 Quite High
Spinal cord 2 75.00 Quite High
agonist 107 74.96 Quite High
Paracetamol 1 72.36 Quite High
anesthesia 5 69.36 Quite High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 8 99.44 Very High Very High Very High
Heart Rate Under Development 6 99.30 Very High Very High Very High
Injury 15 98.88 Very High Very High Very High
Apoptosis 10 96.68 Very High Very High Very High
Neuropathic Pain 1 93.40 High High
Natriuresis 2 91.24 High High
Toxicity 1 87.44 High High
Drug Induced Neurotoxicity 4 84.48 Quite High
Frailty 8 83.56 Quite High
Death 4 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the differentiated stage, 1 muM MeHgCl induced selective loss of S100 beta-expressing astrocytic cells.
Negative_regulation (loss) of Gene_expression (expressing) of S100
1) Confidence 0.43 Published 2009 Journal Stem Cells Section Abstract Doc Link 19609937 Disease Relevance 0.55 Pain Relevance 0.28
The S100B protein concentration was measured in all samples using a commercially available immunoluminometric assay (Liaison Sangtec 100 Diasorin S.p.A.
Negative_regulation (measured) of Gene_expression (concentration) of S100B protein
2) Confidence 0.43 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2423355 Disease Relevance 0 Pain Relevance 0
The S100B levels at these time points will be referred to as T0, T1, T2....T48.
Negative_regulation (referred) of Gene_expression (levels) of S100B
3) Confidence 0.43 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0 Pain Relevance 0
We conclude that landiolol can be effectively used in the treatment of tachycardia in SAH patients and significantly reduced the serum S-100beta levels 24 hours after the operation.
Negative_regulation (reduced) of Gene_expression (levels) of S-100beta associated with heart rate under development and cva
4) Confidence 0.42 Published 2010 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 20118792 Disease Relevance 0.79 Pain Relevance 0.33
A biochemical model was established using S100beta, GFAP, and IL-8 to predict injury severity (ASIA A, B, or C).
Negative_regulation (established) of Gene_expression (using) of S100beta associated with injury
5) Confidence 0.41 Published 2010 Journal J. Neurotrauma Section Abstract Doc Link 20038240 Disease Relevance 1.28 Pain Relevance 0.39
Mean estimated true release of S100B, calculated according to equation [1], was lower at T1 and T2 compared to measured S100B levels (1.43 ± 1.37 ?
Negative_regulation (lower) of Gene_expression (levels) of S100B
6) Confidence 0.37 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544890 Disease Relevance 0.07 Pain Relevance 0
S100B levels progressively decreased during DrotAA infusion in patients with a GCS <13 only (0.96 ± 0.22 ?
Negative_regulation (decreased) of Gene_expression (levels) of S100B
7) Confidence 0.37 Published 2010 Journal Crit Care Section Body Doc Link PMC2887172 Disease Relevance 0 Pain Relevance 0
These data confirm the specificity of the Rab5 data and, moreover, confirm that the observed decline in Rab5 expression in the S100 fractions owing to its translocation from the cytosolic fractions was indeed a cicaprost-induced event and was not due to lack of uniformity in protein loading, for example.
Negative_regulation (decline) of Gene_expression (expression) of S100
8) Confidence 0.10 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.06

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