INT161716

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Context Info
Confidence 0.74
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 2.17
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nkx2-5) nucleus (Nkx2-5) DNA binding (Nkx2-5)
transcription factor binding (Nkx2-5) cytoplasm (Nkx2-5)
Anatomy Link Frequency
bladder 3
urinary bladder 2
coronary artery 1
Nkx2-5 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 7 100.00 Very High Very High Very High
substance P 132 99.48 Very High Very High Very High
Inflammation 168 96.04 Very High Very High Very High
ischemia 2 94.88 High High
Inflammatory response 24 58.88 Quite High
Serotonin 6 26.80 Quite Low
Nerve growth factor 6 12.16 Low Low
antagonist 30 5.00 Very Low Very Low Very Low
Inflammatory mediators 12 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Angina 6 100.00 Very High Very High Very High
INFLAMMATION 198 96.04 Very High Very High Very High
Cv Unclassified Under Development 1 94.88 High High
Congenital Anomalies 1 93.60 High High
Cancer 24 91.88 High High
Coronary Artery Disease 1 90.04 High High
Muscular Spasm 1 87.40 High High
Syndrome 8 86.28 High High
Natriuresis 12 82.52 Quite High
Microvascular Angina 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this article we report clinical evidence in three patients of the simultaneous occurrence of angina episodes typical of both VA and CSX, suggesting that common pathogenetic factors may be responsible for clinical manifestations both of functional macrovascular and microvascular coronary artery abnormalities in some angina patients.
Localization (typical) of CSX in coronary artery associated with angina and congenital anomalies
1) Confidence 0.74 Published 2009 Journal Clin Cardiol Section Abstract Doc Link 19610123 Disease Relevance 1.15 Pain Relevance 0.71
Intravesical instillation of SP stimulates NF-kappaB and Nkx-2.5 translocation in the bladder mucosa
Localization (translocation) of Nkx-2.5 in bladder associated with substance p
2) Confidence 0.34 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0 Pain Relevance 0.09
An interesting finding was the constitutive translocation of NKx-2.5 and NF-kappaB in the bladder mucosa.
Localization (translocation) of NKx-2.5 in bladder
3) Confidence 0.34 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.29 Pain Relevance 0.04
In the presence of NK1R, Nkx-2.5 _01 was significantly correlated with 36 transcripts which included several candidates for mediating bladder development (FGF) and inflammation (PAR-3, IL-1R, IL-6, NGF, TSP2) (Table 3, [additional file 3]).
Localization (correlated) of Nkx-2.5 in bladder associated with inflammation
4) Confidence 0.32 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.33 Pain Relevance 0.05
The similarity of basal translocation of NKx-2.5 and NF-kappaB translocation in the urinary bladder may be related to an overlap of binding motifs in some genes.
Localization (translocation) of NKx-2.5 in urinary bladder
5) Confidence 0.30 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.13 Pain Relevance 0.04
The similarity of basal translocation of NKx-2.5 and NF-kappaB translocation in the urinary bladder may be related to an overlap of binding motifs in some genes.
Localization (translocation) of NKx-2.5 in urinary bladder
6) Confidence 0.30 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.13 Pain Relevance 0.04
Next, we used EMSA to confirm that selected TREs (NF-kappaB and NKx-2.5) are indeed part of the molecular network downstream of NK1R activation.
Localization (selected) of NKx-2.5
7) Confidence 0.28 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.13 Pain Relevance 0.06

General Comments

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