INT16175

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Context Info
Confidence 0.11
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.75
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (CACNA1F)
CACNA1F (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 3 97.48 Very High Very High Very High
corticosteroid 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
Paresthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vomiting 12 100.00 Very High Very High Very High
Headache 3 97.48 Very High Very High Very High
Drug Induced Neurotoxicity 22 95.72 Very High Very High Very High
Diarrhoea 1 94.84 High High
Toxicity 90 94.20 High High
Anxiety Disorder 1 92.40 High High
Alopecia 6 92.28 High High
Ovarian Cancer 94 88.84 High High
Disease 44 88.40 High High
Cancer 24 82.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Attempts to include PLD in front-line treatment have also been attempted: in particular, with the aim of improving PTX/JM8 efficacy, sequential doublets or triplet combinations including PLD have been investigated based also on the very favorable and not overlapping toxicity profile.
Positive_regulation (improving) of JM8 associated with toxicity
1) Confidence 0.11 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952486 Disease Relevance 0.77 Pain Relevance 0
The trial showed a statistically significant superiority of PLD/JM8 over PTX/JM8 combination in terms of PFS.
Positive_regulation (superiority) of JM8
2) Confidence 0.11 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952486 Disease Relevance 0.76 Pain Relevance 0
We conclude that APZ increases the antiemetic effect of MCP on JM8.
Positive_regulation (increases) of JM8 associated with vomiting
3) Confidence 0.11 Published 1991 Journal Chemotherapy Section Abstract Doc Link 1804597 Disease Relevance 1.22 Pain Relevance 0.10

General Comments

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