INT161750

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 7.05
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) cytoplasm (Ghrl)
Anatomy Link Frequency
pancreatic islets 1
cardiac muscle 1
plasma 1
endothelial cells 1
colon 1
Ghrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 192 99.36 Very High Very High Very High
Neuropeptide 11 88.08 High High
antagonist 57 78.88 Quite High
Somatostatin 21 71.44 Quite High
qutenza 4 66.60 Quite High
medulla 13 66.40 Quite High
tolerance 12 57.36 Quite High
Enkephalin 1 54.28 Quite High
agonist 51 37.72 Quite Low
nud 20 30.56 Quite Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 14 99.46 Very High Very High Very High
INFLAMMATION 198 99.36 Very High Very High Very High
Frailty 20 96.40 Very High Very High Very High
Insulin Resistance 15 94.68 High High
Obesity 205 93.68 High High
Syndrome 9 92.96 High High
Colitis 8 91.36 High High
Infection 150 91.32 High High
Increased Venous Pressure Under Development 12 89.16 High High
Necrosis 16 87.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that 1) patients with UC show an increased mucosal expression of mRNA for ghrelin in the colonic mucosa which could trigger protective response in inflamed colon; and 2) exogenous ghrelin accelerates healing of colonic lesions in animal model of ulcerative colitis via increased release of NO and PGE(2) due to an increase in iNOS and COX-2 expression and stimulation of sensory neuropeptides such as CGRP released from sensory afferent endings.
Transcription (expression) of ghrelin in colon associated with inflammatory bowel disease and neuropeptide
1) Confidence 0.67 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 19617644 Disease Relevance 0.73 Pain Relevance 0.19
The aim of the present study was: 1) to examine the expression of ghrelin and TNF-alpha mRNA in the inflamed colonic mucosa of patients with ulcerative colitis (UC), 2) to analyze the effect of treatment with exogenous ghrelin on the healing of trinitrobenze sulphonic acid (TNBS)-induced colitis in rats, and 3) to assess the effects of ghrelin treatment on mRNA expression for iNOS and protein expression for COX-2 and PPARalpha in intact colonic mucosa and in that with TNBS-induced colitis.
Spec (examine) Transcription (expression) of ghrelin associated with colitis and inflammatory bowel disease
2) Confidence 0.52 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 19617644 Disease Relevance 0.75 Pain Relevance 0.13
Adult pancreatic islets express relatively little ghrelin protein and few GHS receptors, but fetal and neonatal islets exhibit abundant ghrelin gene transcripts and peptide in epsilon cells [452–454].
Transcription (express) of ghrelin in pancreatic islets
3) Confidence 0.37 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.85 Pain Relevance 0.10
Ghrelin mRNA expression in the gastric fundic mucosa increased significantly in the treatment group compared with the control group (4.47±2.14 vs. 1.79±0.96, P<0.01).
Transcription (expression) of Ghrelin
4) Confidence 0.36 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.21 Pain Relevance 0
Thus, we could expect the change of ghrelin mRNA expression to continue to increase with the reduction of inflammation after treatment.
Transcription (expression) of ghrelin associated with inflammation
5) Confidence 0.36 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.96 Pain Relevance 0.13
In summary, we demonstrated that ghrelin mRNA expression in the gastric mucosa increased after H. pylori eradication.
Transcription (expression) of ghrelin
6) Confidence 0.36 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.48 Pain Relevance 0.04
As shown in Fig. 2, gastric ghrelin mRNA expression increased substantially with treatment for all subjects in the treatment group but showed inconsistent or minor changes in the control group (Fig. 3).
Transcription (expression) of ghrelin
7) Confidence 0.32 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.21 Pain Relevance 0
Furthermore, ghrelin transcripts and protein are expressed in endothelial cells and cardiac muscle [466, 472].
Transcription (transcripts) of ghrelin in cardiac muscle
8) Confidence 0.29 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.56 Pain Relevance 0.10
This randomized controlled trial demonstrates that H. pylori eradication increases ghrelin mRNA expression, independent of inflammatory cell changes.



Transcription (expression) of ghrelin associated with inflammation
9) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2811295 Disease Relevance 0.39 Pain Relevance 0.09
Analysis of variance (ANOVA) was used to compare the expression of ghrelin mRNA and TNF-?
Transcription (expression) of ghrelin
10) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.09 Pain Relevance 0
Ghrelin mRNA expression in the fundic mucosa after H. pylori eradication increased significantly compared to the control group (4.47±2.14 vs. 1.79±0.96, P=0.009), independent of inflammatory changes.
Transcription (expression) of Ghrelin associated with inflammation
11) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2811295 Disease Relevance 0.41 Pain Relevance 0.05
According to the multiple regression analysis, which excluded possible confounding factors such as inflammations and weight change, the eradication of H. pylori was an important factor related to increased ghrelin mRNA expression, regardless of inflammation (P=0.004, not shown in the Tables).
Transcription (expression) of ghrelin associated with inflammation
12) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.24 Pain Relevance 0.09
This study showed a significant increase in ghrelin mRNA expression in the gastric mucosa after H. pylori eradication.
Transcription (expression) of ghrelin
13) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.23 Pain Relevance 0.08
Ghrelin mRNA expression increased with a decrease in mononuclear cell infiltration (P=0.046, Table 3), but not with the changes in infiltrating neutrophils.
Transcription (expression) of Ghrelin in neutrophils
14) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.24 Pain Relevance 0.08
Ghrelin and GHSR-1a immunostaining were detected in sheep ovarian follicles at all developmental stages, mainly in the granulosa cells.
Transcription (detected) of Ghrelin in granulosa cells
15) Confidence 0.23 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0.05
Analysis of plasma ghrelin levels after 8 weeks of KD (Figure 5) determined that there were no diet-related differences between dietary groups at any time point prior to the dietary switch.
Transcription (levels) of ghrelin in plasma
16) Confidence 0.19 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2781796 Disease Relevance 0.16 Pain Relevance 0
Furthermore, ghrelin transcripts and protein are expressed in endothelial cells and cardiac muscle [466, 472].
Transcription (transcripts) of ghrelin in endothelial cells
17) Confidence 0.10 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.56 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox