INT161751

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 10
Disease Relevance 3.89
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) cytoplasm (Ghrl)
Anatomy Link Frequency
colon 4
neutrophils 2
Ghrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 128 99.36 Very High Very High Very High
Neuropeptide 2 88.08 High High
qutenza 4 67.32 Quite High
nud 16 30.56 Quite Low
COX2 4 25.00 Low Low
drug abuse 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 14 99.82 Very High Very High Very High
INFLAMMATION 128 99.36 Very High Very High Very High
Infection 120 91.32 High High
Necrosis 8 87.88 High High
Cancer 24 87.52 High High
Colitis 8 84.56 Quite High
Obesity 128 78.88 Quite High
Gastritis 48 75.00 Quite High
Ulcers 96 31.04 Quite Low
Dyspepsia 16 30.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that 1) patients with UC show an increased mucosal expression of mRNA for ghrelin in the colonic mucosa which could trigger protective response in inflamed colon; and 2) exogenous ghrelin accelerates healing of colonic lesions in animal model of ulcerative colitis via increased release of NO and PGE(2) due to an increase in iNOS and COX-2 expression and stimulation of sensory neuropeptides such as CGRP released from sensory afferent endings.
Positive_regulation (increased) of Transcription (expression) of ghrelin in colon associated with inflammatory bowel disease and neuropeptide
1) Confidence 0.49 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 19617644 Disease Relevance 0.74 Pain Relevance 0.19
We conclude that 1) patients with UC show an increased mucosal expression of mRNA for ghrelin in the colonic mucosa which could trigger protective response in inflamed colon; and 2) exogenous ghrelin accelerates healing of colonic lesions in animal model of ulcerative colitis via increased release of NO and PGE(2) due to an increase in iNOS and COX-2 expression and stimulation of sensory neuropeptides such as CGRP released from sensory afferent endings.
Positive_regulation (for) of Transcription (expression) of ghrelin in colon associated with inflammatory bowel disease and neuropeptide
2) Confidence 0.49 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 19617644 Disease Relevance 0.73 Pain Relevance 0.19
Ghrelin mRNA expression in the gastric fundic mucosa increased significantly in the treatment group compared with the control group (4.47±2.14 vs. 1.79±0.96, P<0.01).
Positive_regulation (increased) of Transcription (expression) of Ghrelin
3) Confidence 0.35 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.21 Pain Relevance 0
As shown in Fig. 2, gastric ghrelin mRNA expression increased substantially with treatment for all subjects in the treatment group but showed inconsistent or minor changes in the control group (Fig. 3).
Positive_regulation (increased) of Transcription (expression) of ghrelin
4) Confidence 0.31 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.21 Pain Relevance 0
Ghrelin mRNA expression in the fundic mucosa after H. pylori eradication increased significantly compared to the control group (4.47±2.14 vs. 1.79±0.96, P=0.009), independent of inflammatory changes.
Positive_regulation (increased) of Transcription (expression) of Ghrelin associated with inflammation
5) Confidence 0.24 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2811295 Disease Relevance 0.42 Pain Relevance 0.05
This study showed a significant increase in ghrelin mRNA expression in the gastric mucosa after H. pylori eradication.
Positive_regulation (increase) of Transcription (expression) of ghrelin
6) Confidence 0.24 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.23 Pain Relevance 0.08
According to the multiple regression analysis, which excluded possible confounding factors such as inflammations and weight change, the eradication of H. pylori was an important factor related to increased ghrelin mRNA expression, regardless of inflammation (P=0.004, not shown in the Tables).
Positive_regulation (increased) of Transcription (expression) of ghrelin associated with inflammation
7) Confidence 0.24 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.24 Pain Relevance 0.09
In summary, we demonstrated that ghrelin mRNA expression in the gastric mucosa increased after H. pylori eradication.
Positive_regulation (increased) of Transcription (expression) of ghrelin
8) Confidence 0.24 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.49 Pain Relevance 0.04
This randomized controlled trial demonstrates that H. pylori eradication increases ghrelin mRNA expression, independent of inflammatory cell changes.



Positive_regulation (increases) of Transcription (expression) of ghrelin associated with inflammation
9) Confidence 0.24 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2811295 Disease Relevance 0.39 Pain Relevance 0.09
Ghrelin mRNA expression increased with a decrease in mononuclear cell infiltration (P=0.046, Table 3), but not with the changes in infiltrating neutrophils.
Neg (not) Positive_regulation (increased) of Transcription (expression) of Ghrelin in neutrophils
10) Confidence 0.24 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2811295 Disease Relevance 0.24 Pain Relevance 0.08

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