INT161754

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 4.06
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
Anatomy Link Frequency
stroma 1
liver 1
theca 1
ovary 1
Ppara (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 125 87.92 High High
Inflammation 120 86.16 High High
agonist 88 85.20 High High
Potency 28 84.48 Quite High
Inflammatory mediators 1 77.96 Quite High
qutenza 2 67.76 Quite High
COX2 2 25.00 Low Low
Neuropeptide 1 25.00 Low Low
cytokine 37 5.00 Very Low Very Low Very Low
rheumatoid arthritis 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colitis 4 98.64 Very High Very High Very High
Inflammatory Bowel Disease 7 95.98 Very High Very High Very High
Arthritis 257 95.96 Very High Very High Very High
Obesity 63 94.24 High High
INFLAMMATION 134 86.16 High High
Apoptosis 33 78.72 Quite High
Body Weight 34 65.24 Quite High
Breast Cancer 8 58.56 Quite High
Wound Healing 5 56.36 Quite High
Metabolic Syndrome 16 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
lacking, with the exception of a study that showed limited penile PPAR?
Neg (exception) Transcription (exception) of PPAR
1) Confidence 0.52 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.17 Pain Relevance 0
In contrast, expression level of the PPAR-?
Transcription (level) of PPAR
2) Confidence 0.43 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275770 Disease Relevance 0 Pain Relevance 0
In the liver, mRNA levels of PPAR-?
Transcription (levels) of PPAR in liver
3) Confidence 0.41 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 0.93 Pain Relevance 0.12
Figure 7 shows that mRNA levels of PPAR-?
Transcription (levels) of PPAR
4) Confidence 0.41 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 0.96 Pain Relevance 0.15
RT–PCR analysis comparing Srebp-1c, Ppard, Ppara, Ins (proinsulin), Ucp-2, Ampk and Gck mRNA expression in BRIN-BD11 cells treated in the absence or presence of increasing concentrations of AA for 24 h was performed.
Transcription (expression) of Ppara
5) Confidence 0.30 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0 Pain Relevance 0
M AA compared with cells cultured in control medium, whereas the relative expression levels of Ppara and Ppard mRNA in cells treated with 50 or 100 ?
Transcription (levels) of Ppara
6) Confidence 0.26 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0 Pain Relevance 0
Finally, one could underline that the contribution of PPAR?
Transcription (contribution) of PPAR
7) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.22 Pain Relevance 0.26
is found primarily in the theca and stroma, whereas mRNA for PPAR?
Transcription (found) of PPAR in stroma
8) Confidence 0.23 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.28 Pain Relevance 0.04
In the rat ovary, the expression of mRNA for PPAR?
Transcription (expression) of PPAR in ovary
9) Confidence 0.23 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.28 Pain Relevance 0.04
is found primarily in the theca and stroma, whereas mRNA for PPAR?
Transcription (found) of PPAR in theca
10) Confidence 0.08 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.28 Pain Relevance 0.04
The aim of the present study was: 1) to examine the expression of ghrelin and TNF-alpha mRNA in the inflamed colonic mucosa of patients with ulcerative colitis (UC), 2) to analyze the effect of treatment with exogenous ghrelin on the healing of trinitrobenze sulphonic acid (TNBS)-induced colitis in rats, and 3) to assess the effects of ghrelin treatment on mRNA expression for iNOS and protein expression for COX-2 and PPARalpha in intact colonic mucosa and in that with TNBS-induced colitis.
Transcription (expression) of PPARalpha associated with colitis and inflammatory bowel disease
11) Confidence 0.04 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 19617644 Disease Relevance 0.93 Pain Relevance 0.19

General Comments

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