INT161757

Context Info Confidence 0.59 First Reported 2008 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 2.36 Pain Relevance 0.23

extracellular space (CSF3) extracellular region (CSF3) enzyme binding (CSF3)

Anatomy Link Frequency granulocyte 1 CSF3 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 30 99.42 Inflammation 38 86.76 Pain 2 10.00 ketamine 2 5.00 anesthesia 2 5.00 isoflurane 2 5.00 cva 2 5.00 palliative 1 5.00 methotrexate 1 5.00 Paresthesia 1 5.00

Disease Link Frequency Relevance Heat Neutropenia 28 100.00 Influenza Virus Infection 76 98.90 Neuropathic Pain 4 96.20 Infection 58 95.84 Diarrhoea 10 95.12 Fever 12 92.84 Toxicity 38 87.08 INFLAMMATION 38 86.76 Disease 18 74.72 Disease Progression 2 73.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In 14 cases pegfilgrastim replaced GCSF (filgrastim or lenograstim), after a median of 6.9 years of GCSF therapy.

Negative_regulation (replaced) of GCSF

1) Confidence 0.59 Published 2009 Journal Pediatr Blood Cancer Section Body Doc Link 19618456 Disease Relevance 0.09 Pain Relevance 0

It should be noted, that with the use of granulocyte colony stimulating factors (GCSF) as secondary prevention, the rate of complicated neutropenia was reduced to 12% with DCF as compared to 27% without GCSF in patients treated with DCF.

Negative_regulation (reduced) of GCSF in granulocyte associated with neutropenia

2) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621422 Disease Relevance 1.11 Pain Relevance 0

In this model, influenza-infected mice treated with Ekybion showed significant decreases in GCSF, GM-CSF, and IL-6 (Figure 4(a)).

Negative_regulation (decreases) of GCSF associated with influenza virus infection

3) Confidence 0.03 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2959154 Disease Relevance 0.73 Pain Relevance 0.10

Mice treated with Ekybion displayed a general trend toward lower cytokine production with significant decreases in GCSF (6.0-fold decrease), GM-CSF (4.0-fold decrease), and IL-6 (3.5-fold decrease) in the 1X 2?

Negative_regulation (decreases) of GCSF associated with cytokine

4) Confidence 0.03 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2959154 Disease Relevance 0.44 Pain Relevance 0.13

General Comments

This test has worked.