INT161757

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.36
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF3) extracellular region (CSF3) enzyme binding (CSF3)
Anatomy Link Frequency
granulocyte 1
CSF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 30 99.42 Very High Very High Very High
Inflammation 38 86.76 High High
Pain 2 10.00 Low Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Paresthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neutropenia 28 100.00 Very High Very High Very High
Influenza Virus Infection 76 98.90 Very High Very High Very High
Neuropathic Pain 4 96.20 Very High Very High Very High
Infection 58 95.84 Very High Very High Very High
Diarrhoea 10 95.12 Very High Very High Very High
Fever 12 92.84 High High
Toxicity 38 87.08 High High
INFLAMMATION 38 86.76 High High
Disease 18 74.72 Quite High
Disease Progression 2 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 14 cases pegfilgrastim replaced GCSF (filgrastim or lenograstim), after a median of 6.9 years of GCSF therapy.
Negative_regulation (replaced) of GCSF
1) Confidence 0.59 Published 2009 Journal Pediatr Blood Cancer Section Body Doc Link 19618456 Disease Relevance 0.09 Pain Relevance 0
It should be noted, that with the use of granulocyte colony stimulating factors (GCSF) as secondary prevention, the rate of complicated neutropenia was reduced to 12% with DCF as compared to 27% without GCSF in patients treated with DCF.
Negative_regulation (reduced) of GCSF in granulocyte associated with neutropenia
2) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621422 Disease Relevance 1.11 Pain Relevance 0
In this model, influenza-infected mice treated with Ekybion showed significant decreases in GCSF, GM-CSF, and IL-6 (Figure 4(a)).
Negative_regulation (decreases) of GCSF associated with influenza virus infection
3) Confidence 0.03 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2959154 Disease Relevance 0.73 Pain Relevance 0.10
Mice treated with Ekybion displayed a general trend toward lower cytokine production with significant decreases in GCSF (6.0-fold decrease), GM-CSF (4.0-fold decrease), and IL-6 (3.5-fold decrease) in the 1X 2?
Negative_regulation (decreases) of GCSF associated with cytokine
4) Confidence 0.03 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2959154 Disease Relevance 0.44 Pain Relevance 0.13

General Comments

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